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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7,8-dihydrobiopterin
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Accession:CHEBI:64277 term browser browse the term
Definition:A dihydropterin that is biopterin dihydrogenated at positions 7 and 8.
Synonyms:exact_synonym: 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydropteridin-4(1H)-one
 related_synonym: Formula=C9H13N5O3;   InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17);   InChIKey=FEMXZDUTFRTWPE-UHFFFAOYSA-N;   SMILES=CC(O)C(O)C1=Nc2c(NC1)[nH]c(N)nc2=O;   quinonoid dihydro-(6H)-biopterin
 xref: KEGG:C02953
 xref_mesh: MESH:C017226
 xref: MetaCyc:CPD0-2050


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L-erythro-7,8-dihydrobiopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions
ISO APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin
GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin]
CTD PMID:22886847 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin] CTD PMID:25041251 PMID:25490417 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases abundance
multiple interactions
ISO GCH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]
CTD PMID:25490417 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides] CTD PMID:19011239 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  pteridines 10207
                    pterins 9369
                      biopterins 11
                        7,8-dihydrobiopterin 4
                          D-erythro-7,8-dihydrobiopterin 0
                          L-erythro-7,8-dihydrobiopterin 4
                          L-threo-7,8-dihydrobiopterin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterobicyclic compound 16814
                                      pteridines 10207
                                        pterins 9369
                                          biopterins 11
                                            7,8-dihydrobiopterin 4
                                              D-erythro-7,8-dihydrobiopterin 0
                                              L-erythro-7,8-dihydrobiopterin 4
                                              L-threo-7,8-dihydrobiopterin 0
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