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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61992
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gch1
Name: GTP cyclohydrolase 1
Acc ID: CHEBI:43029
Term: L-erythro-7,8-dihydrobiopterin
Definition: A 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form.
Chemical ID: MESH:C017226
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gch1increases abundanceISORGD:15512456480464CTDGCH1 gene mutant form results in increased abundance of 7 8-dihydrobiopterin

PMID:25490417
Gch1multiple interactionsISORGD:15512456480464CTD[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7 8-dihydrobiopterin]

PMID:25490417
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