CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: isopentenyl diphosphate
Accession: CHEBI:16584
browse the term
Definition: A prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.
Synonyms: related_synonym: 3-Methyl-3-butenyl pyrophosphate; 3-methylbut-3-en-1-yl trihydrogen diphosphate; 3-methylbut-3-enyl phosphono hydrogen phosphate; Diphosphoric acid mono(3-methyl-3-butenyl) ester; Formula=C5H12O7P2; IPP; IPPP; InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8); InChIKey=NUHSROFQTUXZQQ-UHFFFAOYSA-N; Isopentenyl pyrophosphate; Mono(3-methyl-3-butenyl) diphosphate; SMILES=CC(=C)CCOP(O)(=O)OP(O)(O)=O; delta-3-Isopentenyl pyrophosphate; delta3-Methyl-3-butenyl diphosphate; delta3-isopentenyl diphosphate
alt_id: CHEBI:14473; CHEBI:24907; CHEBI:6037
xref: CAS:358-71-4; DrugBank:DB04714; KEGG:C00129; KNApSAcK:C00000848; LIPID_MAPS_instance:LMPR01010008
xref_mesh: MESH:C004809
xref: PDBeChem:IPE; PMID:11278429; PMID:15450402; PMID:23000003; PMID:23543734; PMID:23747531; PMID:23872678; PMID:7584140; PMID:7753173; Reaxys:1713792; Wikipedia:Isopentenyl_pyrophosphate
cyclic_relationship: is_conjugate_acid_of CHEBI:128769
G
Ccr5
C-C motif chemokine receptor 5
decreases expression
ISO
isopentenyl pyrophosphate results in decreased expression of CCR5 protein
CTD
PMID:11994442
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
G
Fdps
farnesyl diphosphate synthase
multiple interactions
ISO
[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate
CTD
PMID:19699819
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
G
Fgf9
fibroblast growth factor 9
increases expression
ISO
isopentenyl pyrophosphate results in increased expression of FGF9 mRNA; isopentenyl pyrophosphate results in increased expression of FGF9 protein
CTD
PMID:14704367
NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
G
Ifng
interferon gamma
multiple interactions increases expression
ISO
Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IFNG protein]
CTD
PMID:15879110
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il2ra
interleukin 2 receptor subunit alpha
multiple interactions increases expression
ISO
Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IL2RA protein]
CTD
PMID:15879110
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Mvk
mevalonate kinase
multiple interactions decreases activity
ISO
isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid] isopentenyl pyrophosphate results in decreased activity of MVK protein
CTD
PMID:9392419
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
G
Trpa1
transient receptor potential cation channel, subfamily A, member 1
multiple interactions
ISO
isopentenyl pyrophosphate inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
CTD
PMID:21353389
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
G
Trpv3
transient receptor potential cation channel, subfamily V, member 3
multiple interactions
ISO
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD
PMID:21353389
NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
G
Vdr
vitamin D receptor
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; Go 6976 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; U 0126 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]
CTD
PMID:15879110
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all