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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621295
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:16584
Term: isopentenyl diphosphate
Definition: A prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.
Chemical ID: MESH:C004809
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mvkdecreases activityISORGD:7320316480464CTDisopentenyl pyrophosphate results in decreased activity of MVK proteinPMID:9392419
Mvkmultiple interactionsISORGD:7320316480464CTDisopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]PMID:9392419
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