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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:promazine
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Accession:CHEBI:8459 term browser browse the term
Definition:A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
Synonyms:exact_synonym: N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
 related_synonym: 10-(3-(Dimethylamino)propyl)phenothiazine;   Formula=C17H20N2S;   InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3;   InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N;   N-(3-Dimethylaminopropyl)phenothiazine;   N-Dimethylamino-1-methylethyl thiodiphenylamine;   SMILES=CN(C)CCCN1c2ccccc2Sc2ccccc12;   promazina;   promazinum
 xref: Beilstein:244925;   CAS:58-40-2;   DrugBank:DB00420;   Drug_Central:2284;   HMDB:HMDB0014564;   KEGG:C07379;   KEGG:D08430;   LINCS:LSM-2137
 xref_mesh: MESH:D011395
 xref: PMID:1650428;   PMID:18423639;   PMID:19306624;   PMID:20825390;   Patent:US2519886;   Reaxys:244925;   Wikipedia:Promazine


show annotations for term's descendants           Sort by:
promazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Promazine results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Promazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Promazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        pharmacological role 19064
          antagonist 17248
            dopaminergic antagonist 1636
              promazine 4
                promazine hydrochloride 0
                promazine sulfoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        tertiary amino compound 10141
                                          tertiary amine 644
                                            promazine 4
                                              promazine hydrochloride 0
                                              promazine sulfoxide 0
paths to the root