CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: axitinib
Accession: CHEBI:66910
Definition: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms: exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide related_synonym: AG-013736; Formula=C22H18N4OS; InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+; InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N; Inlyta; N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide; SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1; axitinibum xref: CAS:319460-85-0; Drug_Central:4225; KEGG:D03218 xref_mesh: MESH:C503983 xref: PMID:20740300; PMID:21301929; PMID:21670972; PMID:22168366; PMID:22170007; PMID:22248343; PMID:22504156; PMID:22545314; PMID:22549112; PMID:22644797; PMID:22683928; PMID:22699078; PMID:22706540; PMID:22733795; PMID:22787405; Reaxys:11333336; Wikipedia:Axitinib
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide
CTD PMID:31299239
NCBI chr12:9,207,978...9,230,064
G
Mapk1 mitogen activated protein kinase 1
multiple interactions
ISO mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein]
CTD PMID:27560553
NCBI chr11:97,462,025...97,529,193
G
Mapk3 mitogen activated protein kinase 3
multiple interactions
ISO mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein]
CTD PMID:27560553
NCBI chr 1:190,797,189...190,803,411
G
Nos3 nitric oxide synthase 3
multiple interactions
ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]
CTD PMID:27044328
NCBI chr 4:11,686,088...11,706,604
G
Pak1 p21 (RAC1) activated kinase 1
multiple interactions
ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein]
CTD PMID:27044328
NCBI chr 1:152,111,172...152,226,390
G
Thbs1 thrombospondin 1
multiple interactions
EXP axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]
CTD PMID:18202011
NCBI chr 3:125,510,250...125,525,402
G
Tp53 tumor protein p53
affects activity
ISO Axitinib affects the activity of TP53 protein
CTD PMID:35435491
NCBI chr10:54,798,871...54,810,300
G
Vegfa vascular endothelial growth factor A
multiple interactions
ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]; axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein]
CTD PMID:27044328
NCBI chr 9:22,452,854...22,468,194
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