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indapamide - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indapamide
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Accession:CHEBI:5893 term browser browse the term
Definition:A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Synonyms:exact_synonym: 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
 related_synonym: Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23);   InChIKey=NDDAHWYSQHTHNT-UHFFFAOYSA-N;   SMILES=CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O;   indapamida;   indapamidum
 xref: CAS:26807-65-8;   DrugBank:DB00808;   Drug_Central:1433;   KEGG:D00345;   LINCS:LSM-1936
 xref_mesh: MESH:D007190
 xref: PMID:22567944;   PMID:22579001;   PMID:22606892;   PMID:22725706;   Patent:FR2003311;   Patent:US3565911;   Reaxys:1604026;   Wikipedia:Indapamide

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indapamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A increases expression ISO Indapamide results in increased expression of ADRA2A protein CTD PMID:2829625 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Indapamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP Indapamide affects the expression of FOS mRNA CTD PMID:11779033 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK1 protein CTD PMID:11779033 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK3 protein CTD PMID:11779033 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ren renin increases expression ISO Indapamide results in increased expression of REN protein CTD PMID:6578003 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Indapamide affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:4,755,287...4,758,491
Ensembl chr20:4,753,598...4,756,577 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Indapamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            diuretic 4117
              indapamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              monocarboxylic acid amide 15949
                                                arenecarboxamide 8283
                                                  benzamides 8283
                                                    benzamide 64
                                                      indapamide 8
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