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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzamide
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Accession:CHEBI:28179 term browser browse the term
Definition:An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Synonyms:related_synonym: Benzenecarboxamide;   Benzoic acid amide;   Benzoylamide;   Formula=C7H7NO;   InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9);   InChIKey=KXDAEFPNCMNJSK-UHFFFAOYSA-N;   PhC(O)NH2;   Phenylcarboxamide;   Phenylcarboxyamide;   SMILES=NC(=O)c1ccccc1
 alt_id: CHEBI:22701;   CHEBI:3021;   CHEBI:46351;   MESH:C037689
 xref: Beilstein:385876;   CAS:55-21-0;   HMDB:HMDB0004461;   KEGG:C09815
 xref_mesh: MESH:C037689
 xref: PMID:20133863;   Reaxys:385876;   UM-BBD_compID:c0368;   Wikipedia:Benzamide

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benzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA] CTD PMID:29935282 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Casp3 caspase 3 increases activity ISO benzamide results in increased activity of CASP3 protein CTD PMID:18695944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression ISO benzamide results in increased expression of CHRM1 mRNA; benzamide results in increased expression of CHRM1 protein CTD PMID:18501976 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]] CTD PMID:17157789 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:29935282 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO
EXP		 benzamide analog binds to and results in decreased activity of CXCR1 protein CTD PMID:17181143 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions EXP benzamide analog binds to and results in decreased activity of CXCR2 protein CTD PMID:17181143 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA] CTD PMID:29935282 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO benzamide analog results in decreased activity of EGFR protein CTD PMID:15186837 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased localization of ESR1 protein]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein] CTD PMID:17157789 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]
benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]		 CTD PMID:18762200 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]] CTD PMID:18762200 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]] CTD PMID:18762200 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]
benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]		 CTD PMID:18762200 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Gck glucokinase increases activity ISO benzamide analog results in increased activity of GCK protein CTD PMID:19758809 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO [INS1 protein co-treated with benzamide] results in increased activity of GPD1 protein; benzamide promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of GPD1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[INS1 protein co-treated with benzamide] results in increased activity of GPD1 protein] CTD PMID:2523799 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Hdac1 histone deacetylase 1 decreases activity ISO benzamide analog results in decreased activity of HDAC1 protein CTD PMID:19362838 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO benzamide analog results in decreased activity of HDAC3 protein CTD PMID:19362838 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO benzamide analog results in decreased activity of HSD11B1 protein CTD PMID:18553955 PMID:19217779 PMID:19564108 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression		 EXP benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]
benzamide results in decreased expression of IFNG mRNA		 CTD PMID:12411406 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP benzamide results in decreased expression of IL1B mRNA CTD PMID:12411406 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression		 EXP benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]
benzamide results in decreased expression of IL2 mRNA		 CTD PMID:12411406 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO benzamide analog results in decreased activity of LYN protein CTD PMID:17376680 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form] CTD PMID:29935282 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form] CTD PMID:29935282 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA] CTD PMID:29935282 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO benzamide analog binds to and results in increased activity of MPL protein CTD PMID:18396041 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]] CTD PMID:17157789 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]] CTD PMID:17157789 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA] CTD PMID:29935282 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form] CTD PMID:29935282 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO
EXP		 benzamide results in decreased expression of NOS2 mRNA; benzamide results in decreased expression of NOS2 protein CTD PMID:12411406 PMID:18501976 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO benzamide inhibits the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]; benzamide inhibits the reaction [PARP1 protein binds to MOR enhancer mutant form]; benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]] CTD PMID:19447888 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase multiple interactions ISO benzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine]; benzamide inhibits the reaction [PARG affects the susceptibility to Vitamin K 3] CTD PMID:15591342 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; benzamide inhibits the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]; benzamide inhibits the reaction [PARP1 protein binds to MOR enhancer mutant form]; benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]
benzamide results in decreased expression of PARP1 protein
[benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; benzamide inhibits the reaction [[Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]		 CTD PMID:11593040 PMID:12411406 PMID:17669606 PMID:18695944 PMID:19447888 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP benzamide results in increased expression of PCNA protein CTD PMID:11049868 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP benzamide results in decreased expression of PTGS2 mRNA CTD PMID:12411406 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pygl glycogen phosphorylase L decreases activity ISO benzamide analog results in decreased activity of PYGL protein CTD PMID:19758809 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO benzamide analog results in decreased activity of SIRT1 protein CTD PMID:19616958 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 multiple interactions EXP benzamide analog binds to and results in decreased activity of SLC6A9 protein CTD PMID:18355687 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO benzamide analog results in decreased activity of SRC protein CTD PMID:15186837 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tep1 telomerase associated protein 1 decreases expression ISO benzamide results in decreased expression of TEP1 mRNA; benzamide results in decreased expression of TEP1 protein CTD PMID:16098204 NCBI chr15:24,045,876...24,093,526
Ensembl chr15:24,045,878...24,093,526 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases ADP-ribosylation		 ISO benzamide results in decreased activity of TERT protein
benzamide results in decreased ADP-ribosylation of TERT protein		 CTD PMID:16098204 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:17157789 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 EXP
ISO		 benzamide results in decreased expression of TNF mRNA
benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]
benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]		 CTD PMID:12411406 PMID:19447888 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
benzamidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr13:96,324,377...96,362,677 JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr13:96,362,810...96,397,284 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime CTD PMID:15788365 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO UGT1A3 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime CTD PMID:15788365 NCBI chr 9:88,791,216...88,808,465 JBrowse link
indapamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A increases expression ISO Indapamide results in increased expression of ADRA2A protein CTD PMID:2829625 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Indapamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP Indapamide affects the expression of FOS mRNA CTD PMID:11779033 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK1 protein CTD PMID:11779033 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK3 protein CTD PMID:11779033 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ren renin increases expression ISO Indapamide results in increased expression of REN protein CTD PMID:6578003 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Indapamide affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:4,753,587...4,756,590
Ensembl chr20:4,753,598...4,756,577 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Indapamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19808
      atom 19807
        nonmetal atom 19694
          nitrogen atom 18758
            nitrogen molecular entity 18758
              amide 17552
                aromatic amide 7454
                  arenecarboxamide 7263
                    benzamides 7263
                      benzamide 61
                        6-(4-\{(1S,2S)-2-amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropyl\}phenyl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium 0
                        N-[2-(2-aminoethoxy)ethyl]-4-(2-hydroxy-4-phenylcyclohexyl)benzamide 0
                        N-benzoyl-1-methylpyridin-4(1H)-imine 0
                        N-butyrylbenzamide 0
                        N-propylbenzamide 0
                        benzamido group 0
                        benzamidoxime 6
                        imatinib + 0
                        indapamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        carboacyl group 17481
                                          univalent carboacyl group 17481
                                            carbamoyl group 17297
                                              carboxamide 17297
                                                monocarboxylic acid amide 15014
                                                  arenecarboxamide 7263
                                                    benzamides 7263
                                                      benzamide 61
                                                        6-(4-\{(1S,2S)-2-amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropyl\}phenyl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium 0
                                                        N-[2-(2-aminoethoxy)ethyl]-4-(2-hydroxy-4-phenylcyclohexyl)benzamide 0
                                                        N-benzoyl-1-methylpyridin-4(1H)-imine 0
                                                        N-butyrylbenzamide 0
                                                        N-propylbenzamide 0
                                                        benzamido group 0
                                                        benzamidoxime 6
                                                        imatinib + 0
                                                        indapamide 8
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