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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzamide
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Accession:CHEBI:28179 term browser browse the term
Definition:An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Synonyms:related_synonym: Benzenecarboxamide;   Benzoic acid amide;   Benzoylamide;   Formula=C7H7NO;   InChI=1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9);   InChIKey=KXDAEFPNCMNJSK-UHFFFAOYSA-N;   PhC(O)NH2;   Phenylcarboxamide;   Phenylcarboxyamide;   SMILES=NC(=O)c1ccccc1
 alt_id: CHEBI:22701;   CHEBI:3021;   CHEBI:46351;   MESH:C037689
 xref: Beilstein:385876;   CAS:55-21-0;   HMDB:HMDB0004461;   KEGG:C09815
 xref_mesh: MESH:C037689
 xref: PMID:20133863;   Reaxys:385876;   UM-BBD_compID:c0368;   Wikipedia:Benzamide


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benzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA] CTD PMID:29935282 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Casp3 caspase 3 increases activity ISO benzamide results in increased activity of CASP3 protein CTD PMID:18695944 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression ISO benzamide results in increased expression of CHRM1 mRNA; benzamide results in increased expression of CHRM1 protein CTD PMID:18501976 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Ctsd cathepsin D multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]] CTD PMID:17157789 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctsk cathepsin K multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:29935282 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO
EXP
benzamide analog binds to and results in decreased activity of CXCR1 protein CTD PMID:17181143 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions EXP benzamide analog binds to and results in decreased activity of CXCR2 protein CTD PMID:17181143 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA] CTD PMID:29935282 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO benzamide analog results in decreased activity of EGFR protein CTD PMID:15186837 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased localization of ESR1 protein]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein] CTD PMID:17157789 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]
benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]
CTD PMID:18762200 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]] CTD PMID:18762200 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]] CTD PMID:18762200 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta multiple interactions ISO benzamide analog binds to and results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]; benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRD protein]]
benzamide analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRD protein]]
CTD PMID:18762200 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gck glucokinase increases activity ISO benzamide analog results in increased activity of GCK protein CTD PMID:19758809 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO [INS1 protein co-treated with benzamide] results in increased activity of GPD1 protein; benzamide promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of GPD1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[INS1 protein co-treated with benzamide] results in increased activity of GPD1 protein] CTD PMID:2523799 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Hdac1 histone deacetylase 1 decreases activity ISO benzamide analog results in decreased activity of HDAC1 protein CTD PMID:19362838 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO benzamide analog results in decreased activity of HDAC3 protein CTD PMID:19362838 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO benzamide analog results in decreased activity of HSD11B1 protein CTD PMID:18553955, PMID:19217779, PMID:19564108 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA]
benzamide results in decreased expression of IFNG mRNA
CTD PMID:12411406 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP benzamide results in decreased expression of IL1B mRNA CTD PMID:12411406 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
EXP benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]
benzamide results in decreased expression of IL2 mRNA
CTD PMID:12411406 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO benzamide analog results in decreased activity of LYN protein CTD PMID:17376680 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form] CTD PMID:29935282 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form] CTD PMID:29935282 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA] CTD PMID:29935282 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO benzamide analog binds to and results in increased activity of MPL protein CTD PMID:18396041 NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]] CTD PMID:17157789 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]] CTD PMID:17157789 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA] CTD PMID:29935282 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form] CTD PMID:29935282 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO
EXP
benzamide results in decreased expression of NOS2 mRNA; benzamide results in decreased expression of NOS2 protein CTD PMID:12411406, PMID:18501976 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO benzamide inhibits the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]; benzamide inhibits the reaction [PARP1 protein binds to MOR enhancer mutant form]; benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]] CTD PMID:19447888 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase multiple interactions ISO benzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine]; benzamide inhibits the reaction [PARG affects the susceptibility to Vitamin K 3] CTD PMID:15591342 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases activity
decreases expression
ISO
EXP
[benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; benzamide inhibits the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]; benzamide inhibits the reaction [PARP1 protein binds to MOR enhancer mutant form]; benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]
benzamide results in decreased expression of PARP1 protein
[benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; benzamide inhibits the reaction [[Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]
CTD PMID:11593040, PMID:12411406, PMID:17669606, PMID:18695944, PMID:19447888, PMID:19998477 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP benzamide results in increased expression of PCNA protein CTD PMID:11049868 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP benzamide results in decreased expression of PTGS2 mRNA CTD PMID:12411406 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pygl glycogen phosphorylase L decreases activity ISO benzamide analog results in decreased activity of PYGL protein CTD PMID:19758809 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO benzamide analog results in decreased activity of SIRT1 protein CTD PMID:19616958 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc6a9 solute carrier family 6 member 9 multiple interactions EXP benzamide analog binds to and results in decreased activity of SLC6A9 protein CTD PMID:18355687 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO benzamide analog results in decreased activity of SRC protein CTD PMID:15186837 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tep1 telomerase associated protein 1 decreases expression ISO benzamide results in decreased expression of TEP1 mRNA; benzamide results in decreased expression of TEP1 protein CTD PMID:16098204 NCBI chr15:27,751,186...27,798,839
Ensembl chr15:27,751,180...27,798,839
JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases ADP-ribosylation
ISO benzamide results in decreased activity of TERT protein
benzamide results in decreased ADP-ribosylation of TERT protein
CTD PMID:16098204 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:17157789 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
benzamide results in decreased expression of TNF mRNA
benzamide inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]
benzamide inhibits the reaction [TNF protein promotes the reaction [[PARP1 protein binds to MOR enhancer mutant form] which results in increased expression of MOR mRNA]]
CTD PMID:12411406, PMID:19447888 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of DCSTAMP mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK1 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MAPK3 protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFKBIA protein modified form]; benzamide analog inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of RELA protein modified form] CTD PMID:29935282 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
benzamidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of benzamidoxime CTD PMID:22924387 NCBI chr13:102,724,266...102,755,511
Ensembl chr13:102,724,348...102,756,174
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime CTD PMID:15788365 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO UGT1A3 protein results in increased glucuronidation of and results in decreased activity of benzamidoxime CTD PMID:15788365 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
indapamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A increases expression ISO Indapamide results in increased expression of ADRA2A protein CTD PMID:2829625 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Indapamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP Indapamide affects the expression of FOS mRNA CTD PMID:11779033 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK1 protein CTD PMID:11779033 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation EXP Indapamide affects the phosphorylation of MAPK3 protein CTD PMID:11779033 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ren renin increases expression ISO Indapamide results in increased expression of REN protein CTD PMID:6578003 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-DOa RT1 class II, locus DOa affects expression ISO Indapamide affects the expression of HLA-DOA mRNA CTD PMID:25811541 NCBI chr20:3,889,106...3,892,360
Ensembl chr20:3,889,370...3,892,449
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Indapamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

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  CHEBI ontology 19770
    chemical entity 19769
      atom 19768
        nonmetal atom 19642
          nitrogen atom 18532
            nitrogen molecular entity 18532
              amide 17371
                aromatic amide 6673
                  arenecarboxamide 6508
                    benzamides 6508
                      benzamide 61
                        6-(4-\{(1S,2S)-2-amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropyl\}phenyl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium 0
                        N-[2-(2-aminoethoxy)ethyl]-4-(2-hydroxy-4-phenylcyclohexyl)benzamide 0
                        N-benzoyl-1-methylpyridin-4(1H)-imine 0
                        N-butyrylbenzamide 0
                        N-propylbenzamide 0
                        benzamido group 0
                        benzamidoxime 6
                        imatinib + 0
                        indapamide 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        carboacyl group 17334
                                          univalent carboacyl group 17334
                                            carbamoyl group 17118
                                              carboxamide 17118
                                                monocarboxylic acid amide 14549
                                                  arenecarboxamide 6508
                                                    benzamides 6508
                                                      benzamide 61
                                                        6-(4-\{(1S,2S)-2-amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxopropyl\}phenyl)-1H-[1,2,4]triazolo[1,5-a]pyridin-4-ium 0
                                                        N-[2-(2-aminoethoxy)ethyl]-4-(2-hydroxy-4-phenylcyclohexyl)benzamide 0
                                                        N-benzoyl-1-methylpyridin-4(1H)-imine 0
                                                        N-butyrylbenzamide 0
                                                        N-propylbenzamide 0
                                                        benzamido group 0
                                                        benzamidoxime 6
                                                        imatinib + 0
                                                        indapamide 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.