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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,4'-thiodiphenol
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Accession:CHEBI:38957 term browser browse the term
Definition:A phenol that has formula C12H10O2S.
Synonyms:exact_synonym: 4,4'-sulfanediyldiphenol
 related_synonym: 4,4'-Dihydroxydiphenyl sulfide;   Bis(4-oxyphenyl)sulfide;   Formula=C12H10O2S;   InChI=1S/C12H10O2S/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8,13-14H;   InChIKey=VWGKEVWFBOUAND-UHFFFAOYSA-N;   SMILES=Oc1ccc(Sc2ccc(O)cc2)cc1;   p,p'-Dihydroxydiphenyl sulfide
 xref: Beilstein:2050739;   CAS:2664-63-3
 xref_mesh: MESH:C586730


show annotations for term's descendants           Sort by:
4,4'-thiodiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding ISO bis(4-oxyphenyl)sulfide binds to AR protein CTD PMID:31836225 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions
increases expression		 ISO bis(4-oxyphenyl)sulfide binds to ESR1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of ESR1 protein]		 CTD PMID:27880919 PMID:31836225 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding ISO bis(4-oxyphenyl)sulfide binds to ESR2 protein CTD PMID:31836225 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased expression of GPER1 protein] CTD PMID:27880919 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO bis(4-oxyphenyl)sulfide results in decreased activity of HSD11B2 protein CTD PMID:36871355 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein] CTD PMID:27880919 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein] CTD PMID:27880919 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
temephos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Temefos results in decreased activity of ACHE protein CTD PMID:34382084 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases activity ISO Temefos results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Temefos inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22308
    chemical entity 22307
      molecular entity 22302
        polyatomic entity 22156
          heteroatomic molecular entity 22091
            hydroxides 20866
              organic hydroxy compound 19833
                phenols 19355
                  4,4'-thiodiphenol 10
                    temephos 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 22308
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22183
                    p-block element atom 22183
                      carbon group element atom 21985
                        carbon atom 21924
                          organic molecular entity 21924
                            heteroorganic entity 21563
                              organochalcogen compound 21057
                                organosulfur compound 18218
                                  organic sulfide 10469
                                    aryl sulfide 8646
                                      diphenyl sulfide 10
                                        4,4'-thiodiphenol 10
                                          temephos 3
paths to the root