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vosaroxin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vosaroxin
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Accession:CHEBI:231651 term browser browse the term
Definition:A 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells.
Synonyms:exact_synonym: 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
 related_synonym: (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid;   AG-7352;   AG7352;   Formula=C18H19N5O4S;   InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1;   InChIKey=XZAFZXJXZHRNAQ-STQMWFEESA-N;   SMILES=CN[C@H]1CN(C[C@@H]1OC)C1=NC2=C(C=C1)C(=O)C(=CN2C1=NC=CS1)C(O)=O;   SNS-595;   SPC-595;   voreloxin;   vosaroxina;   vosaroxine;   vosaroxinum
 xref: CAS:175414-77-4;   DrugBank:DB11999;   KEGG:D08024
 xref_mesh: MESH:C485113
 xref: PMID:15056007;   PMID:18931998;   PMID:19074528;   PMID:20419121;   PMID:22369205;   PMID:22724917;   PMID:23688047;   PMID:25381131;   PMID:25403830;   PMID:25534904;   PMID:25805811;   PMID:25958926;   PMID:26234173;   PMID:27158854;   PMID:27236532;   PMID:27484675;   PMID:27615555;   PMID:28138829;   PMID:28415741;   PMID:28504025;   PMID:28567238;   PMID:28729302;   PMID:28860803;   PMID:29794146;   PMID:29800573;   PMID:30396931;   PMID:31115744;   PMID:31482470;   Patent:US2011312988;   Wikipedia:Vosaroxin

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vosaroxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]] CTD PMID:29800573 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Casp3 caspase 3 increases activity ISO vosaroxin results in increased activity of CASP3 protein CTD PMID:29800573 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency affects the localization of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]] CTD PMID:29800573 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases activity
multiple interactions		 ISO vosaroxin results in increased activity of IDH2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]		 CTD PMID:29800573 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]; SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein] CTD PMID:29800573 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein] CTD PMID:29800573 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions		 ISO vosaroxin results in increased activity of SOD2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]		 CTD PMID:29800573 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          apoptosis inducer 13666
            vosaroxin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  organic heteropolycyclic compound 18302
                                    organic heterobicyclic compound 17242
                                      mancude organic heterobicyclic parent 8376
                                        naphthyridine 2254
                                          1,8-naphthyridine 1910
                                            1,8-naphthyridine derivative 1910
                                              vosaroxin 7
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