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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vosaroxin
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Accession:CHEBI:231651 term browser browse the term
Definition:A 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells.
Synonyms:exact_synonym: 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
 related_synonym: (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid;   AG-7352;   AG7352;   Formula=C18H19N5O4S;   InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1;   InChIKey=XZAFZXJXZHRNAQ-STQMWFEESA-N;   SMILES=CN[C@H]1CN(C[C@@H]1OC)C1=NC2=C(C=C1)C(=O)C(=CN2C1=NC=CS1)C(O)=O;   SNS-595;   SPC-595;   voreloxin;   vosaroxina;   vosaroxine;   vosaroxinum
 xref: CAS:175414-77-4;   DrugBank:DB11999;   KEGG:D08024
 xref_mesh: MESH:C485113
 xref: PMID:15056007;   PMID:18931998;   PMID:19074528;   PMID:20419121;   PMID:22369205;   PMID:22724917;   PMID:23688047;   PMID:25381131;   PMID:25403830;   PMID:25534904;   PMID:25805811;   PMID:25958926;   PMID:26234173;   PMID:27158854;   PMID:27236532;   PMID:27484675;   PMID:27615555;   PMID:28138829;   PMID:28415741;   PMID:28504025;   PMID:28567238;   PMID:28729302;   PMID:28860803;   PMID:29794146;   PMID:29800573;   PMID:30396931;   PMID:31115744;   PMID:31482470;   Patent:US2011312988;   Wikipedia:Vosaroxin


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vosaroxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]] CTD PMID:29800573 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Casp3 caspase 3 increases activity ISO vosaroxin results in increased activity of CASP3 protein CTD PMID:29800573 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency affects the localization of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]] CTD PMID:29800573 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases activity
multiple interactions		 ISO vosaroxin results in increased activity of IDH2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]		 CTD PMID:29800573 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]; SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein] CTD PMID:29800573 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein] CTD PMID:29800573 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions		 ISO vosaroxin results in increased activity of SOD2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]		 CTD PMID:29800573 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19825
      biological role 19823
        biochemical role 19534
          apoptosis inducer 13657
            vosaroxin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19685
                              organic cyclic compound 19496
                                organic heterocyclic compound 18871
                                  organic heteropolycyclic compound 18299
                                    organic heterobicyclic compound 17246
                                      mancude organic heterobicyclic parent 8336
                                        naphthyridine 2301
                                          1,8-naphthyridine 1912
                                            1,8-naphthyridine derivative 1912
                                              vosaroxin 7
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