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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylamine N-oxide
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Accession:CHEBI:15724 term browser browse the term
Definition:A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Synonyms:related_synonym: (CH3)3NO;   Formula=C3H9NO;   InChI=1S/C3H9NO/c1-4(2,3)5/h1-3H3;   InChIKey=UYPYRKYUKCHHIB-UHFFFAOYSA-N;   Me3N(O);   N(CH3)3O;   N,N-dimethylmethanamine oxide;   SMILES=C[N+](C)([O-])C;   TMAO;   Trimethylaminoxid;   trimethylamine oxide;   trimethyloxamine
 alt_id: CHEBI:15262;   CHEBI:15263;   CHEBI:27126;   CHEBI:9733
 xref: Beilstein:1734787;   CAS:1184-78-7;   Gmelin:1839;   HMDB:HMDB0000925;   KEGG:C01104
 xref_mesh: MESH:C005855
 xref: MetaCyc:TRIMENTHLAMINE-N-O;   PDBeChem:TMO;   PMID:12683801;   PMID:1453985;   PMID:17697669;   PMID:19425246;   PMID:22770225;   PMID:3170512;   PMID:3674879;   Reaxys:1734787;   Wikipedia:Trimethylamine_oxide
 cyclic_relationship: is_conjugate_base_of CHEBI:166856


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trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        osmolyte 3446
          trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        amine 8269
                                          alkylamines 190
                                            methylamines 17
                                              trimethylamine 9
                                                trimethylamine N-oxide 7
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