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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethylamine
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Accession:CHEBI:18139 term browser browse the term
Definition:A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.
Synonyms:related_synonym: (CH3)3N;   Formula=C3H9N;   InChI=1S/C3H9N/c1-4(2)3/h1-3H3;   InChIKey=GETQZCLCWQTVFV-UHFFFAOYSA-N;   N(CH3)3;   N,N,N-trimethylamine;   N,N-Dimethylmethanamine;   NMe3;   SMILES=CN(C)C;   TMA;   Trimethylamin;   tridimethylaminomethane
 alt_id: CHEBI:15261;   CHEBI:27125;   CHEBI:27127;   CHEBI:9732
 xref: Beilstein:956566;   CAS:75-50-3;   Gmelin:1309;   HMDB:HMDB0000906;   KEGG:C00565;   KNApSAcK:C00001433
 xref_mesh: MESH:C023336
 xref: MetaCyc:TRIMETHYLAMINE;   PDBeChem:KEN;   PMID:14047118;   PMID:15304308;   PMID:15752091;   PMID:17190852;   PMID:1801314;   PMID:24591617;   PMID:2501587;   PMID:5161463;   Reaxys:956566;   Wikipedia:Trimethylamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58389



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trimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases oxidation
multiple interactions
increases metabolic processing
ISO
EXP
FMO3 gene polymorphism affects the metabolism of trimethylamine
FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine
trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole]
FMO3 protein results in increased metabolism of trimethylamine
CTD PMID:11414682 PMID:12214664 PMID:16601883 PMID:17050781 PMID:17142560 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases chemical synthesis
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine
MTARC1 protein results in increased chemical synthesis of trimethylamine
CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677 JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Taar5 trace amine-associated receptor 5 increases activity ISO trimethylamine results in increased activity of TAAR5 protein CTD PMID:23393561 NCBI chr 1:21,469,923...21,470,936
Ensembl chr 1:21,469,923...21,470,936
JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677 JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        biochemical role 19380
          metabolite 19358
            xenobiotic metabolite 14487
              human xenobiotic metabolite 13875
                trimethylamine 9
                  trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            inorganic hydride 17700
                              pnictogen hydride 17681
                                nitrogen hydride 17552
                                  azane 17289
                                    ammonia 17288
                                      organic amino compound 17288
                                        amine 7826
                                          alkylamines 185
                                            methylamines 17
                                              trimethylamine 9
                                                trimethylamine N-oxide 7
paths to the root