Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethylamine
go back to main search page
Accession:CHEBI:18139 term browser browse the term
Definition:A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.
Synonyms:related_synonym: (CH3)3N;   Formula=C3H9N;   InChI=1S/C3H9N/c1-4(2)3/h1-3H3;   InChIKey=GETQZCLCWQTVFV-UHFFFAOYSA-N;   N(CH3)3;   N,N,N-trimethylamine;   N,N-Dimethylmethanamine;   NMe3;   SMILES=CN(C)C;   TMA;   Trimethylamin;   tridimethylaminomethane
 alt_id: CHEBI:15261;   CHEBI:27125;   CHEBI:27127;   CHEBI:9732
 xref: Beilstein:956566;   CAS:75-50-3;   Gmelin:1309;   HMDB:HMDB0000906;   KEGG:C00565;   KNApSAcK:C00001433
 xref_mesh: MESH:C023336
 xref: MetaCyc:TRIMETHYLAMINE;   PDBeChem:KEN;   PMID:14047118;   PMID:15304308;   PMID:15752091;   PMID:17190852;   PMID:1801314;   PMID:24591617;   PMID:2501587;   PMID:5161463;   Reaxys:956566;   Wikipedia:Trimethylamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58389


show annotations for term's descendants           Sort by:
 
trimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases oxidation
multiple interactions
increases metabolic processing
ISO
EXP
FMO3 gene polymorphism affects the metabolism of trimethylamine
FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine
trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole]
FMO3 protein results in increased metabolism of trimethylamine
CTD PMID:11414682, PMID:12214664, PMID:16601883, PMID:17050781, PMID:17142560 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases chemical synthesis
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine
MTARC1 protein results in increased chemical synthesis of trimethylamine
CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Taar5 trace amine-associated receptor 5 increases activity ISO trimethylamine results in increased activity of TAAR5 protein CTD PMID:23393561 NCBI chr 1:22,547,662...22,548,675
Ensembl chr 1:22,547,662...22,548,675
JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            xenobiotic metabolite 14041
              human xenobiotic metabolite 13294
                trimethylamine 9
                  trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        amine 7601
                                          alkylamines 183
                                            methylamines 17
                                              trimethylamine 9
                                                trimethylamine N-oxide 7
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.