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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alkylamines
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Accession:CHEBI:22331 term browser browse the term
Definition:Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups.

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2-phenylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions ISO phenethylamine binds to and results in decreased activity of ADRA1A protein CTD PMID:20217639 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra2a adrenoceptor alpha 2A affects binding ISO phenethylamine binds to ADRA2A protein CTD PMID:20217639 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081 		JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding ISO phenethylamine binds to ADRA2C protein CTD PMID:20217639 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010 		JBrowse link
G Maob monoamine oxidase B multiple interactions ISO Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine] CTD PMID:3961266 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases transport		 ISO Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]; SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:15764732 PMID:17234900 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity		 ISO [phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475 		JBrowse link
4-methoxyphenylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO O-methyltyramine results in increased activity of TAAR1 protein
[O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475 		JBrowse link
4-phenylbutylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO 4-phenylbutylamine results in increased expression of ABCC4 mRNA; 4-phenylbutylamine results in increased expression of ABCC4 protein CTD PMID:20395535 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA] CTD PMID:24291486 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of DDIT3 protein] CTD PMID:30394307 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 multiple interactions ISO 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HERPUD1 protein] CTD PMID:30394307 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA] CTD PMID:24291486 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HSPA5 protein] CTD PMID:30394307 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA] CTD PMID:24291486 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
benzylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO benzylamine binds to and results in increased activity of AHR protein CTD PMID:11790108 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Kng2 kininogen 2 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
dimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene increases secretion ISO DEK protein results in increased secretion of dimethylamine CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions ISO
EXP		 dimethylamine binds to and results in decreased activity of HRH3 protein CTD PMID:17169555 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395 		JBrowse link
furtrethonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 affects binding
multiple interactions		 ISO CHRM1 protein binds to furtrethonium
brucine promotes the reaction [furtrethonium binds to CHRM1 protein]		 CTD PMID:9224827 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions		 ISO CHRM2 protein binds to furtrethonium
eburnamonine promotes the reaction [furtrethonium binds to CHRM2 protein]		 CTD PMID:9224827 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding		 ISO brucine promotes the reaction [furtrethonium binds to CHRM3 protein]
CHRM3 protein binds to furtrethonium		 CTD PMID:9224827 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding		 ISO brucine promotes the reaction [furtrethonium binds to CHRM4 protein]
CHRM4 protein binds to furtrethonium		 CTD PMID:9224827 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
methylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase, copper containing 3 decreases amination
multiple interactions		 ISO AOC3 protein results in decreased amination of methylamine
mofegiline inhibits the reaction [AOC3 protein results in decreased amination of methylamine]		 CTD PMID:15128865 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 multiple interactions ISO methylamine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IFNAR1 protein] CTD PMID:18722370 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061 		JBrowse link
G Kcna6 potassium voltage-gated channel subfamily A member 6 affects response to substance ISO KCNA6 protein affects the susceptibility to methylamine CTD PMID:15100162 NCBI chr 4:159,253,934...159,287,193
Ensembl chr 4:159,253,934...159,287,193 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions ISO methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein] CTD PMID:11181932 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
methylamines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Methylamines analog results in decreased activity of CA1 protein CTD PMID:29457667 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Methylamines analog results in decreased activity of CA2 protein CTD PMID:29457667 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
N,O-dimethyltyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Kng2 kininogen 2 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:29402411 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
N-[3-(aminomethyl)benzyl]acetamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 affects response to substance ISO AKT2 protein affects the susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:21964073 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxygen deficiency results in increased expression of CAV1 protein] CTD PMID:18717816 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein] CTD PMID:15542068 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein] CTD PMID:15542068 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein] CTD PMID:21397656 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifng interferon gamma multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647 		JBrowse link
G Lepr leptin receptor increases response to substance EXP LEPR gene mutant form results in increased susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:30689673 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11504810 PMID:11713966 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity		 ISO
EXP		 [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] which results in increased susceptibility to endothelium-dependent hyperpolarization factor; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]		 CTD PMID:11076874 PMID:11134894 PMID:16461118 PMID:16933320 PMID:19442826 PMID:19951519 PMID:20035746 PMID:20497644 PMID:20549418 PMID:23061969 PMID:24964743 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr15:105,851,543...105,852,033
Ensembl chr15:105,851,542...105,878,666 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO
EXP		 Ranitidine binds to and results in decreased activity of ACHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]		 CTD PMID:15669026 PMID:15669039 PMID:16193528 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ACKR3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ADAMTS1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974 		JBrowse link
G Alb albumin multiple interactions EXP [Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein] CTD PMID:28400101 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA CTD PMID:16415329 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Amotl2 angiomotin like 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA] CTD PMID:16415329 NCBI chr 8:111,210,261...111,226,217
Ensembl chr 8:111,209,908...111,226,226 		JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ARHGEF11 mRNA CTD PMID:16415329 NCBI chr 2:186,979,850...187,102,523
Ensembl chr 2:186,980,793...187,101,768 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATF3 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ATF3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA]; Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ATP1B1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]		 CTD PMID:19723537 PMID:30885738 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Ranitidine binds to and results in decreased activity of BCHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein] CTD PMID:15669026 PMID:16193528 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:19723537 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA] CTD PMID:16415329 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA] CTD PMID:16415329 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA CTD PMID:16401727 PMID:16415329 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO Ranitidine results in increased expression of CALCA protein CTD PMID:12495560 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 Ranitidine inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 protein]		 CTD PMID:19723537 PMID:28648817 PMID:29523851 PMID:30885738 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:19723537 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 PMID:16397915 PMID:17895592 PMID:18087811 PMID:18726076 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnl1 cyclin L1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA] CTD PMID:16415329 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA CTD PMID:16415329 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Crem cAMP responsive element modulator multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA] CTD PMID:16415329 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA] CTD PMID:16401727 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Ctsl cathepsin L multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CTSL mRNA CTD PMID:16415329 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Ranitidine results in decreased expression of CXCL1 protein CTD PMID:12023551 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein] CTD PMID:16401727 PMID:16415329 PMID:17698507 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA] CTD PMID:29523851 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA CTD PMID:16415329 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Dio3 iodothyronine deiodinase 3 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA] CTD PMID:16415329 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DUSP1 mRNA CTD PMID:16415329 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Efna1 ephrin A1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA] CTD PMID:16415329 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222 		JBrowse link
G Egfl7 EGF-like-domain, multiple 7 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA CTD PMID:16415329 NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA] CTD PMID:29523851 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGR1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA] CTD PMID:16415329 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA CTD PMID:16415329 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing ISO FMO3 protein affects the metabolism of Ranitidine CTD PMID:15286053 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOS mRNA CTD PMID:16415329 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA] CTD PMID:16415329 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995 		JBrowse link
G Foxq1 forkhead box Q1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOXQ1 mRNA CTD PMID:16415329 NCBI chr17:34,224,308...34,226,941
Ensembl chr17:34,224,818...34,226,453 		JBrowse link
G Fst follistatin multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA] CTD PMID:16415329 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GADD45A mRNA CTD PMID:16415329 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gast gastrin affects expression
multiple interactions		 ISO
EXP		 Ranitidine affects the expression of GAST protein
Ranitidine inhibits the reaction [GAST protein modified form results in increased secretion of Acids]		 CTD PMID:2470453 PMID:12503773 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GOT1 mRNA CTD PMID:16415329 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gzmb granzyme B multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA] CTD PMID:16401727 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G Hist3h2a histone cluster 3, H2a multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of H2A mRNA CTD PMID:16415329 NCBI chr10:45,297,603...45,299,155 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA] CTD PMID:16415329 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA CTD PMID:16415329 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA CTD PMID:16415329 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hoxa5 homeo box A5 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA CTD PMID:16415329
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity		 ISO
EXP		 [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [tiotidine binds to HRH2 protein]
Ranitidine results in decreased activity of HRH2 protein
Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [Dimaprit binds to and results in increased activity of HRH2 protein]; Ranitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein]		 CTD PMID:6106871 PMID:6835285 PMID:7512805 PMID:9681472 PMID:9819373 PMID:11527950 PMID:12100006 PMID:14671421 PMID:16143415 PMID:16632449 PMID:22995146 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HSPA1A mRNA CTD PMID:16415329 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA] CTD PMID:16415329 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12538815 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA] CTD PMID:16415329 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA] CTD PMID:16415329 NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]		 CTD PMID:10569698 PMID:11752121 PMID:16415329 PMID:17698507 PMID:19362101 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IFRD1 mRNA CTD PMID:16415329 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420 		JBrowse link
G Igsf10 immunoglobulin superfamily, member 10 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA] CTD PMID:16401727 NCBI chr 2:149,535,199...149,564,180
Ensembl chr 2:149,533,151...149,564,113 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO		 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]		 CTD PMID:11752121 PMID:17698507 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein] CTD PMID:9819373 PMID:11752121 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein] CTD PMID:9819373 PMID:11752121 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] CTD PMID:11752121 PMID:16723495 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Ranitidine results in increased expression of IL1B protein
Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL1B protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]		 CTD PMID:15265675 PMID:17698507 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL4 protein] CTD PMID:29523851 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL6 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15265675 PMID:16401727 PMID:16415329 PMID:17698507 PMID:28648817 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhbe inhibin subunit beta E multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of INHBE mRNA CTD PMID:16415329 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Insig1 insulin induced gene 1 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA] CTD PMID:16415329 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Insig2 insulin induced gene 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA] CTD PMID:16415329 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA] CTD PMID:16415329 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684 		JBrowse link
G Itpkc inositol-trisphosphate 3-kinase C multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ITPKC mRNA] CTD PMID:16415329 NCBI chr 1:84,018,857...84,040,433
Ensembl chr 1:84,018,859...84,040,433 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of JUN mRNA] CTD PMID:16415329 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669 		JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA] CTD PMID:16415329 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK1 protein] CTD PMID:19723537 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK3 protein] CTD PMID:19723537 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions
increases expression		 EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of MAPKAPK2 mRNA
Ranitidine results in increased expression of MAPKAPK2 mRNA		 CTD PMID:16401727 PMID:16415329 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Ranitidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of MMP9 protein] CTD PMID:17603938 PMID:29523851 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression		 EXP Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]
Ranitidine results in decreased expression of MPO protein		 CTD PMID:12023551 PMID:16169175 PMID:17895592 PMID:18726076 PMID:28648817 PMID:30885738 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of MYC mRNA] CTD PMID:16415329 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA CTD PMID:16415329 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA] CTD PMID:28648817 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Ranitidine inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Noct nocturnin multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NOCT mRNA CTD PMID:16415329 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:16169175 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NR4A1 mRNA CTD PMID:16415329 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NUPR1 mRNA CTD PMID:16415329 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA CTD PMID:16415329 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19723537 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pfkl phosphofructokinase, liver type multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PFKL mRNA CTD PMID:16415329 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PPP1R15A mRNA] CTD PMID:16415329 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Preb prolactin regulatory element binding multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of PREB mRNA] CTD PMID:16415329 NCBI chr 6:26,784,088...26,787,875
Ensembl chr 6:26,784,088...26,787,874 		JBrowse link
G Prl prolactin affects expression
increases secretion		 ISO Ranitidine affects the expression of PRL protein
Ranitidine results in increased secretion of PRL protein		 CTD PMID:7878608 PMID:9037573 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:16401727 PMID:16415329 PMID:29523851 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pvr PVR cell adhesion molecule multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA] CTD PMID:16415329 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA] CTD PMID:16401727 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA protein] CTD PMID:28648817 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin affects activity ISO Ranitidine affects the activity of REN protein CTD PMID:1972605 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS2 mRNA] CTD PMID:16415329 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA] CTD PMID:16415329 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108 		JBrowse link
G Rhob ras homolog family member B multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ARHB mRNA] CTD PMID:16415329 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] CTD PMID:16401727 PMID:16415329 PMID:17698507 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of APS mRNA CTD PMID:16415329 NCBI chr12:23,471,477...23,501,043
Ensembl chr12:23,473,270...23,501,036 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA CTD PMID:16415329 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679 		JBrowse link
G Sik1 salt-inducible kinase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SIK1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SIK1 mRNA] CTD PMID:16415329 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC16A6 mRNA CTD PMID:16415329 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521 		JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC20A1 mRNA CTD PMID:16415329 NCBI chr 3:121,725,204...121,739,160
Ensembl chr 3:121,725,859...121,739,173 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects transport		 ISO
EXP		 Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Ranitidine
SLC22A1 protein affects the transport of Ranitidine		 CTD PMID:16006492 PMID:16141367 PMID:16263091 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases uptake
multiple interactions		 ISO
EXP		 SLC22A2 protein results in increased uptake of Ranitidine
Ranitidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:16006492 PMID:16141367 PMID:16263091 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 PMID:16263091 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of Ranitidine CTD PMID:16006492 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake ISO SLC22A7 protein results in increased uptake of Ranitidine CTD PMID:16006492 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO
EXP		 SLC22A8 protein results in increased uptake of Ranitidine
Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]		 CTD PMID:15319347 PMID:16006492 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC2A1 mRNA] CTD PMID:16415329 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA] CTD PMID:16415329 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ranitidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA] CTD PMID:16401727 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slk STE20-like kinase multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA] CTD PMID:16401727 NCBI chr 1:267,359,761...267,415,735
Ensembl chr 1:267,359,830...267,412,810 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393 		JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO Ranitidine results in increased expression of TAC1 protein CTD PMID:12495560 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tfrc transferrin receptor multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA] CTD PMID:16401727 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:11752121 PMID:12023551 PMID:12538815 PMID:15265675 PMID:17698507 PMID:19362101 PMID:28648817 PMID:29523851 PMID:30885738 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFAIP6 mRNA] CTD PMID:16415329 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF12A mRNA] CTD PMID:16415329 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930 		JBrowse link
G Tpm3 tropomyosin 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA CTD PMID:16415329 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029 		JBrowse link
G Trak2 trafficking kinesin protein 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA CTD PMID:16415329 NCBI chr 9:65,698,706...65,763,351
Ensembl chr 9:65,698,712...65,763,273 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of UBE2B mRNA CTD PMID:16415329 NCBI chr10:37,439,947...37,454,867
Ensembl chr10:37,441,284...37,455,022 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of VEGFA mRNA CTD PMID:16415329 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ZBTB10 mRNA CTD PMID:16415329 NCBI chr 2:94,692,939...94,730,976
Ensembl chr 2:94,692,939...94,730,978 		JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ZFYVE27 mRNA] CTD PMID:16415329 NCBI chr 1:261,415,172...261,438,539
Ensembl chr 1:261,415,191...261,438,539 		JBrowse link
trimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing
multiple interactions
increases oxidation		 ISO
EXP		 FMO3 gene polymorphism affects the metabolism of trimethylamine
FMO3 protein results in increased metabolism of trimethylamine
trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole]
FMO3 protein results in increased oxidation of trimethylamine
FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine		 CTD PMID:11414682 PMID:12214664 PMID:16601883 PMID:17050781 PMID:17142560 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases chemical synthesis		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine
MTARC1 protein results in increased chemical synthesis of trimethylamine		 CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethylamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Taar5 trace amine-associated receptor 5 increases activity ISO trimethylamine results in increased activity of TAAR5 protein CTD PMID:23393561 NCBI chr 1:22,547,662...22,548,675
Ensembl chr 1:22,547,662...22,548,675 		JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction		 ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        refrigerant 17487
          ammonia 17014
            organic amino compound 17013
              amine 7788
                alkylamines 183
                  2-methylpropanamine + 0
                  aralkylamine + 163
                  arylalkylamine + 7
                  dialkylarylamine + 0
                  isopropylamine 0
                  methylamines + 17
                  propylamine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      s-block molecular entity 19491
                        hydrogen molecular entity 19483
                          hydrides 18748
                            inorganic hydride 17481
                              pnictogen hydride 17454
                                nitrogen hydride 17296
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        amine 7788
                                          alkylamines 183
                                            2-methylpropanamine + 0
                                            aralkylamine + 163
                                            arylalkylamine + 7
                                            dialkylarylamine + 0
                                            isopropylamine 0
                                            methylamines + 17
                                            propylamine + 0
paths to the root