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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prostaglandin F2alpha
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Accession:CHEBI:15553 term browser browse the term
Definition:A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.
Synonyms:exact_synonym: (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid
 related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate;   7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid;   9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid;   9a,11a-PGF2;   Amoglandin;   Cyclosin;   Dinoprost;   Enzaprost;   Enzaprost F;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1;   InChIKey=PXGPLTODNUVGFL-YNNPMVKQSA-N;   PGF2a;   PGF2alpha;   Panacelan;   Prostaglandin F2a;   Prostin F 2 alpha;   Protamodin;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   U 14583;   dinoprosta;   dinoprostum;   l-PGF2-alpha;   l-Prostaglandin F2-alpha
 alt_id: CHEBI:10913;   CHEBI:26327;   CHEBI:8516
 xref: CAS:551-11-1;   Drug_Central:912;   HMDB:HMDB0001139;   KEGG:C00639;   KEGG:D00081;   LIPID_MAPS_instance:LMFA03010002
 xref_mesh: MESH:D015237
 xref: MetaCyc:5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY;   PMID:11438482;   PMID:23807981;   Reaxys:2225571;   VSDB:1803;   Wikipedia:Dinoprost
 cyclic_relationship: is_conjugate_acid_of CHEBI:57404


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prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
increases expression
multiple interactions		 EXP Dinoprost results in increased activity of CASP3 protein
Dinoprost results in increased expression of CASP3 mRNA
[epostane co-treated with Dinoprost] results in increased activity of CASP3 protein; Dinoprost promotes the reaction [epostane results in increased expression of CASP3 mRNA]; epostane promotes the reaction [Dinoprost results in increased expression of CASP3 mRNA]		 CTD PMID:20739670 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL2 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL2 mRNA		 CTD PMID:21505051 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL4 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL4 mRNA		 CTD PMID:21505051 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,882...39,481,082 		JBrowse link
G CCL8 chemokine (C-C motif) ligand 8 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCL8 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CCL8 mRNA		 CTD PMID:21505051 NCBI chr12:40,740,468...40,741,970
Ensembl chr12:40,740,023...40,742,022 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 multiple interactions
increases expression		 EXP epostane promotes the reaction [Dinoprost results in increased expression of CCR1 mRNA] CTD PMID:21505051 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCR2 mRNA
epostane promotes the reaction [Dinoprost results in increased expression of CCR2 mRNA]		 CTD PMID:21505051 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CCR5 mRNA
epostane promotes the reaction [Dinoprost results in increased expression of CCR5 mRNA]		 CTD PMID:21505051 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 multiple interactions
increases expression		 EXP [Dinoprost co-treated with epostane] results in increased expression of CXCL2 mRNA
Dinoprost results in increased expression of CXCL2 mRNA		 CTD PMID:21505051 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions		 EXP Dinoprost results in increased expression of CXCL8 mRNA
[Dinoprost co-treated with epostane] results in increased expression of CXCL8 mRNA		 CTD PMID:21505051 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 multiple interactions
increases expression		 EXP epostane promotes the reaction [Dinoprost results in increased expression of CXCR2 mRNA] CTD PMID:21505051 NCBI chr15:120,219,657...120,230,203 JBrowse link
G CYP19A3 cytochrome P450 19A3 multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of CYP19A1 mRNA CTD PMID:20739670 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide increases secretion
multiple interactions		 EXP GHRL protein results in increased secretion of Dinoprost
STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Dinoprost]		 CTD PMID:19528263 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation EXP Dinoprost results in increased phosphorylation of NFKBIA protein CTD PMID:21505051 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions
increases secretion
increases abundance		 EXP Progesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost] CTD PMID:16997130 PMID:21370738 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,586...32,606,546 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA CTD PMID:20739670 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [epostane co-treated with Dinoprost] results in increased expression of PTGS2 mRNA CTD PMID:20739670 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions
increases secretion		 EXP STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Dinoprost]
STAT1 protein results in increased secretion of Dinoprost		 CTD PMID:19528263 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5178
    role 5145
      chemical role 878
        donor 603
          Bronsted acid 445
            oxoacid 438
              carbon oxoacid 398
                carboxylic acid 393
                  monocarboxylic acid 229
                    prostaglandin F2alpha 17
                      11-epi-prostaglandin F2alpha + 0
                      13,14-dihydro-15-keto-PGF2alpha + 0
                      13,14-dihydroprostaglandin F2alpha 0
                      15-oxoprostaglandin F2alpha + 0
                      2,3-dinor-8-epi-prostaglandin F2alpha 0
                      8-epi-prostaglandin F2alpha + 0
                      carboprost 0
                      prostaglandin F2alpha 1-ethanolamide 0
                      prostaglandin F2alpha 1-glyceryl ester 0
                      prostaglandin F2alpha 2-glyceryl ester 0
                      prostaglandin F2alpha dimethylamine 0
                      tafluprost 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5178
    subatomic particle 5169
      composite particle 5169
        hadron 5169
          baryon 5169
            nucleon 5169
              atomic nucleus 5169
                atom 5169
                  main group element atom 5141
                    p-block element atom 5138
                      carbon group element atom 5057
                        carbon atom 5056
                          organic molecular entity 5056
                            heteroorganic entity 4900
                              organochalcogen compound 4854
                                organooxygen compound 4817
                                  carbon oxoacid 398
                                    carboxylic acid 393
                                      monocarboxylic acid 229
                                        fatty acid 132
                                          fatty acid derivative 92
                                            icosanoid 27
                                              prostanoid 27
                                                prostaglandin 22
                                                  prostaglandins F 18
                                                    prostaglandins Falpha 18
                                                      prostaglandin F2alpha 17
                                                        11-epi-prostaglandin F2alpha + 0
                                                        13,14-dihydro-15-keto-PGF2alpha + 0
                                                        13,14-dihydroprostaglandin F2alpha 0
                                                        15-oxoprostaglandin F2alpha + 0
                                                        2,3-dinor-8-epi-prostaglandin F2alpha 0
                                                        8-epi-prostaglandin F2alpha + 0
                                                        carboprost 0
                                                        prostaglandin F2alpha 1-ethanolamide 0
                                                        prostaglandin F2alpha 1-glyceryl ester 0
                                                        prostaglandin F2alpha 2-glyceryl ester 0
                                                        prostaglandin F2alpha dimethylamine 0
                                                        tafluprost 0
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