OXT (oxytocin/neurophysin I prepropeptide) - Rat Genome Database

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Gene: OXT (oxytocin/neurophysin I prepropeptide) Sus scrofa
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Symbol: OXT
Name: oxytocin/neurophysin I prepropeptide
RGD ID: 14275189
Description: ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); oxytocin receptor binding (ortholog); INVOLVED IN drinking behavior (ortholog); eating behavior (ortholog); female pregnancy (ortholog); PARTICIPATES IN oxytocin signaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); Burns (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); secretory granule (ortholog); INTERACTS WITH calcium atom; calcium(0); progesterone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: OT-NPI; oxytocin; oxytocin, prepropeptide; oxytocin-neurophysin 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,605,586 - 32,606,546 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,975,726 - 36,976,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
drinking behavior  (ISO)
eating behavior  (ISO)
female pregnancy  (ISO)
grooming behavior  (ISO)
heart development  (ISO)
hyperosmotic salinity response  (ISO)
male mating behavior  (ISO)
maternal aggressive behavior  (ISO)
maternal behavior  (ISO)
memory  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of gastric acid secretion  (ISO)
negative regulation of urine volume  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of female receptivity  (ISO)
positive regulation of hindgut contraction  (ISO)
positive regulation of norepinephrine secretion  (ISO)
positive regulation of ossification  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
regulation of digestive system process  (ISO)
regulation of heart rate  (ISO)
regulation of sensory perception of pain  (ISO)
response to activity  (ISO)
response to amphetamine  (ISO)
response to cAMP  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ether  (ISO)
response to external biotic stimulus  (ISS)
response to food  (ISO,ISS)
response to glucocorticoid  (ISO)
response to mechanical stimulus  (ISS)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to retinoic acid  (ISO)
response to steroid hormone  (ISO)
response to sucrose  (ISO)
signal transduction  (IEA)
sleep  (ISO)
social behavior  (ISO)
sperm ejaculation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:428540   PMID:1971513   PMID:13022701  


Genomics

Comparative Map Data
OXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,605,586 - 32,606,546 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,975,726 - 36,976,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,071,620 - 3,072,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl203,071,620 - 3,072,517 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,052,266 - 3,053,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,000,266 - 3,001,162 (+)NCBINCBI36Build 36hg18NCBI36
Build 34203,000,265 - 3,001,162NCBI
Celera203,114,251 - 3,115,147 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,998,607 - 2,999,505 (+)NCBIHuRef
CHM1_1203,046,806 - 3,047,704 (+)NCBICHM1_1
T2T-CHM13v2.0203,102,517 - 3,103,415 (+)NCBIT2T-CHM13v2.0
Oxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,416,432 - 130,418,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,418,093 - 130,418,974 (+)EnsemblGRCm39 Ensembl
GRCm382130,574,519 - 130,577,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,576,173 - 130,577,054 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,401,909 - 130,402,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,267,614 - 130,268,429 (+)NCBIMGSCv36mm8
Celera2131,800,597 - 131,801,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
Oxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,782,650 - 117,783,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,782,650 - 117,783,490 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,677,109 - 121,677,940 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03130,274,375 - 130,275,205 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03127,933,240 - 127,934,071 (+)NCBIRnor_WKY
Rnor_6.03123,106,694 - 123,107,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,106,694 - 123,107,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,604,822 - 129,605,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,194,219 - 118,195,056 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,097,303 - 118,100,512 (+)NCBI
Celera3116,593,509 - 116,594,349 (+)NCBICelera
Cytogenetic Map3q36NCBI
OXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0203,157,246 - 3,159,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,193,381 - 18,194,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,193,339 - 18,194,170 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,021,790 - 18,022,393 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,612,328 - 18,612,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,612,281 - 18,613,193 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,205,647 - 18,206,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,318,339 - 18,318,942 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,646,119 - 18,646,759 (-)NCBIUU_Cfam_GSD_1.0
OXT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,749,520 - 33,750,981 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,750,108 - 33,750,968 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,763,922 - 10,764,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,200,478 - 4,201,580 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,200,594 - 4,201,416 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system
High
Medium
Low 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007837   ⟹   ENSSSCP00000007626
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1732,605,586 - 32,606,546 (-)Ensembl
RefSeq Acc Id: NM_001167589   ⟹   NP_001161061
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11732,605,586 - 32,606,449 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001161061 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK58000 (Get FASTA)   NCBI Sequence Viewer  
  P01177 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001161061   ⟸   NM_001167589
- Peptide Label: precursor
- UniProtKB: P01177 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000007626   ⟸   ENSSSCT00000007837


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005020051 UniProtKB/TrEMBL
  ENSSSCG00015061398 UniProtKB/Swiss-Prot
  ENSSSCG00025044498 UniProtKB/Swiss-Prot
  ENSSSCG00030035366 UniProtKB/TrEMBL
  ENSSSCG00035043065 UniProtKB/Swiss-Prot
  ENSSSCG00040028802 UniProtKB/TrEMBL
  ENSSSCG00045002354 UniProtKB/Swiss-Prot
  ENSSSCG00050057938 UniProtKB/Swiss-Prot
  ENSSSCG00055012777 UniProtKB/TrEMBL
  ENSSSCG00060010502 UniProtKB/Swiss-Prot
  ENSSSCG00065064290 UniProtKB/Swiss-Prot
  ENSSSCG00070000178 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000007626 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00005019233.1 UniProtKB/TrEMBL
  ENSSSCP00015033170 UniProtKB/Swiss-Prot
  ENSSSCP00025025625 UniProtKB/Swiss-Prot
  ENSSSCP00030022185.1 UniProtKB/TrEMBL
  ENSSSCP00035022995 UniProtKB/Swiss-Prot
  ENSSSCP00040016184.1 UniProtKB/TrEMBL
  ENSSSCP00045002331 UniProtKB/Swiss-Prot
  ENSSSCP00050033996 UniProtKB/Swiss-Prot
  ENSSSCP00055019985.1 UniProtKB/TrEMBL
  ENSSSCP00060005234 UniProtKB/Swiss-Prot
  ENSSSCP00065038604 UniProtKB/Swiss-Prot
  ENSSSCP00070000249 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000007837 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00005031598.1 UniProtKB/TrEMBL
  ENSSSCT00015081984 UniProtKB/Swiss-Prot
  ENSSSCT00025060419 UniProtKB/Swiss-Prot
  ENSSSCT00030049035.1 UniProtKB/TrEMBL
  ENSSSCT00035057212 UniProtKB/Swiss-Prot
  ENSSSCT00040038691.1 UniProtKB/TrEMBL
  ENSSSCT00045003680 UniProtKB/Swiss-Prot
  ENSSSCT00050079009 UniProtKB/Swiss-Prot
  ENSSSCT00055025150.1 UniProtKB/TrEMBL
  ENSSSCT00060013656 UniProtKB/Swiss-Prot
  ENSSSCT00065088251 UniProtKB/Swiss-Prot
  ENSSSCT00070000302 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.9.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neurhyp_horm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurhyp_horm_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurohypophysial_hormone_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100152272 UniProtKB/Swiss-Prot
NCBI Gene OXT ENTREZGENE
PANTHER PTHR11681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Nonapeptide_hormone_precursor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS NEUROPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROHYPOPHYS_HORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8D0IVQ0_PIG UniProtKB/TrEMBL
  A0A8D1QI87_PIG UniProtKB/TrEMBL
  NEU1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:96466 ENTREZGENE