Mapk14 (mitogen activated protein kinase 14) - Rat Genome Database

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Gene: Mapk14 (mitogen activated protein kinase 14) Rattus norvegicus
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Symbol: Mapk14
Name: mitogen activated protein kinase 14
RGD ID: 70496
Description: Enables ATP binding activity and MAP kinase activity. Involved in several processes, including cellular response to acetaldehyde; cellular response to transforming growth factor beta stimulus; and stress-activated MAPK cascade. Predicted to be located in mitochondrion and spindle pole. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease; anti-basement membrane glomerulonephritis; and interstitial cystitis. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14); PARTICIPATES IN p38 MAPK signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CRK1; Csaids binding protein; CSBP; Csbp1; Csbp2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; Exip; Hog; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; MGC105413; mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha; p38alpha Exip; p38Hog; Prkm14; Prkm15; reactive kinase; RK; Sapk2A; stress-activated protein kinase 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl206,751,357 - 6,812,294 (+)EnsemblGRCr8
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)Ensemblrn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera208,305,853 - 8,366,371 (+)NCBICelera
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4',6-tetrachlorobiphenyl  (EXP)
2,4-dinitroiodobenzene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
AB-Fubinaca  (ISO)
abamectin  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
afimoxifene  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
arachidonic acid  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asiaticoside  (EXP)
asoxime chloride  (EXP)
atorvastatin calcium  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
budesonide  (ISO)
bupropion  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carrageenan  (EXP)
carvacrol  (EXP)
carvedilol  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
chrysophanol  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
coniferyl aldehyde  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cypermethrin  (EXP)
D-glucitol  (ISO)
D-glucose  (ISO)
DAPT  (EXP)
DDT  (ISO)
deoxynivalenol  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diminazene diaceturate  (EXP)
diosmetin  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
doramapimod  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (EXP)
ellagic acid  (EXP)
emetine  (ISO)
emodin  (ISO)
endosulfan  (ISO)
ergosterol  (EXP)
esculetin  (ISO)
esculin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
ferric ammonium citrate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Geraniin  (ISO)
glucose  (ISO)
haloperidol  (EXP)
halothane  (ISO)
hemin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
Icaritin  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
iohexol  (ISO)
iopamidol  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
ketoconazole  (ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
Leptin  (EXP)
limonene  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
lovastatin  (ISO)
lycopene  (EXP,ISO)
lycorine  (ISO)
madecassoside  (ISO)
malvidin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melamine  (ISO)
mercury dichloride  (ISO)
mesalamine  (EXP)
metam  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury(1+)  (ISO)
mevastatin  (ISO)
microcystin-LR  (EXP)
mitomycin C  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nilotinib  (ISO)
nitrates  (ISO)
Nonylphenol  (EXP)
Nookatone  (EXP)
ochratoxin A  (ISO)
octanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
orotic acid  (EXP)
osthole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pirfenidone  (EXP)
potassium chromate  (ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B1  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
pyrazoles  (ISO)
pyrimidines  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
sarin  (EXP)
SB 203580  (EXP,ISO)
SB-239063  (ISO)
scullcapflavone II  (ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trans-chalcone  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vitamin D  (EXP)
vorinostat  (ISO)
VX-745  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (IEA)
bone development  (IEA,ISO)
cartilage condensation  (IEA,ISO)
cell morphogenesis  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (ISO)
cellular response to acetaldehyde  (IEP)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV-B  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO)
cellular response to virus  (IEA)
chondrocyte differentiation  (ISO)
DNA damage checkpoint signaling  (ISO)
DNA damage response  (ISO)
DNA-templated transcription  (IEA)
fatty acid oxidation  (ISO)
glucose metabolic process  (ISO)
intracellular signal transduction  (IBA,IEA,ISO,ISS,TAS)
lipopolysaccharide-mediated signaling pathway  (ISO)
MAPK cascade  (IEA,ISO)
myoblast differentiation involved in skeletal muscle regeneration  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of hippo signaling  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
p38MAPK cascade  (IEA,ISO,ISS)
peptidyl-serine phosphorylation  (ISO)
phosphorylation  (ISO)
placenta development  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of brown fat cell differentiation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of D-glucose import across plasma membrane  (ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of myoblast differentiation  (IEA,ISO,ISS)
positive regulation of myoblast fusion  (IEA,ISO,ISS)
positive regulation of myotube differentiation  (IEA,ISO,ISS)
positive regulation of protein import into nucleus  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IDA,ISO,TAS)
regulation of cytokine production involved in inflammatory response  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of ossification  (ISO)
regulation of synaptic membrane adhesion  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
response to dietary excess  (IEA,ISO)
response to glucose  (IEP)
response to insulin  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
response to muscle stretch  (ISO)
signal transduction  (IEA)
signal transduction in response to DNA damage  (IEA,ISO)
skeletal muscle tissue development  (ISO)
stress-activated MAPK cascade  (IDA,IEA,ISO)
stress-activated protein kinase signaling cascade  (IEA,ISO)
stress-induced premature senescence  (IEA,ISO)
striated muscle cell differentiation  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO,TAS)
glutamatergic synapse  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
spindle pole  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Adams RH, etal., Mol Cell 2000 Jul;6(1):109-16.
2. p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion. Arechederra M, etal., J Biol Chem. 2015 Feb 13;290(7):4383-97. doi: 10.1074/jbc.M114.582239. Epub 2014 Dec 29.
3. Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Bi R, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13391-5.
4. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. Blanco-Aparicio C, etal., J Cell Biol. 1999 Dec 13;147(6):1129-36.
5. Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor. Caverzasio J, etal., J Bone Miner Res. 2008 Sep;23(9):1389-97. doi: 10.1359/jbmr.080410.
6. Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. Chattopadhyay M, etal., J Neurosci. 2008 Jun 25;28(26):6652-8.
7. Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis. Chen JL, etal., Neurourol Urodyn. 2019 Jun;38(5):1250-1260. doi: 10.1002/nau.24005. Epub 2019 Apr 15.
8. The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway. Chen YJ, etal., Life Sci. 2013 Jun 13;92(22):1081-92. doi: 10.1016/j.lfs.2013.04.007. Epub 2013 Apr 26.
9. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
10. Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. D'Addario M, etal., J Biol Chem 2002 Dec 6;277(49):47541-50.
11. Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Du CS, etal., Front Pharmacol. 2010;1:111. Epub 2010 Aug 24.
12. Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death. Eom YW, etal., Biochem Biophys Res Commun 2001 Jun 1;284(1):126-32.
13. Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia. Feng A, etal., PLoS One. 2013 Dec 2;8(12):e80997. doi: 10.1371/journal.pone.0080997. eCollection 2013.
14. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells.PG - Ghosh SK, etal., J Biol Chem 2002 Jun 14;277(24):21325-31.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Gupta J, etal., Cancer Cell. 2014 Apr 14;25(4):484-500. doi: 10.1016/j.ccr.2014.02.019. Epub 2014 Mar 27.
19. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Han J, etal., Science. 1994 Aug 5;265(5173):808-11.
20. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Holasek SS, etal., Brain Res. 2005 May 31;1045(1-2):185-98. Epub 2005 Apr 25.
21. Unilateral amyloid-beta25-35 injection into the rat amygdala increases the expressions of aberrant tau phosphorylation kinases. Huang J, etal., Chin Med J (Engl). 2010 May 20;123(10):1311-4.
22. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Hui L, etal., Nat Genet. 2007 Jun;39(6):741-9. doi: 10.1038/ng2033. Epub 2007 Apr 29.
23. Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer. Jia M, etal., Oncotarget. 2016 May 3;7(18):25291-303. doi: 10.18632/oncotarget.8052.
24. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. Kaiser RA, etal., J Biol Chem. 2004 Apr 9;279(15):15524-30. Epub 2004 Jan 28.
25. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
26. Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.PG - 13752-60 Kerkela R, etal., J Biol Chem 2002 Apr 19;277(16):13752-60.
27. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
28. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. Lejeune D, etal., J Biol Chem 2002 Sep 13;277(37):33676-82. Epub 2002 Jun 26.
29. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
30. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
31. Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. Lim AK, etal., Diabetologia. 2009 Feb;52(2):347-58. Epub 2008 Dec 9.
32. Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma. Liu F, etal., Biofactors. 2020 Jul;46(4):675-684. doi: 10.1002/biof.1639. Epub 2020 May 24.
33. Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism. Liu Y, etal., Alcohol Clin Exp Res. 2011 May;35(5):921-8. doi: 10.1111/j.1530-0277.2010.01422.x. Epub 2011 Feb 5.
34. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. Lu G, etal., J Biol Chem. 2006 Mar 3;281(9):6087-95. Epub 2005 Dec 28.
35. MAPK14 (p38α) inhibition effects against metastatic gastric cancer cells: A potential biomarker and pharmacological target. Mesquita FP, etal., Toxicol In Vitro. 2020 Aug;66:104839. doi: 10.1016/j.tiv.2020.104839. Epub 2020 Mar 31.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. Munoz L, etal., J Neuroinflammation. 2007 Sep 4;4:21.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors. Pikkarainen S, etal., J Biol Chem 2003 Feb 7;278(6):3969-75.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms. Priego N, etal., Oncotarget. 2016 Jul 19;7(29):45060-45078. doi: 10.18632/oncotarget.9911.
44. GOA pipeline RGD automated data pipeline
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Rudalska R, etal., Nat Med. 2014 Oct;20(10):1138-46. doi: 10.1038/nm.3679. Epub 2014 Sep 14.
47. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
48. p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Sakurai T, etal., Cancer Res. 2013 Jan 1;73(1):215-24. doi: 10.1158/0008-5472.CAN-12-1602. Epub 2012 Dec 27.
49. Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. Shukla SD, etal., J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.
50. MAP kinase genes and colon and rectal cancer. Slattery ML, etal., Carcinogenesis. 2012 Dec;33(12):2398-408. doi: 10.1093/carcin/bgs305. Epub 2012 Oct 1.
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52. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Tamura K, etal., Cell 2000 Jul 21;102(2):221-31.
53. Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. Teruel T, etal., J Biol Chem 2003 Jan 3;278(1):263-9.
54. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
55. Dominant negative p38{alpha} mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Thandavarayan RA, etal., Am J Physiol Heart Circ Physiol. 2009 Jul 17.
56. Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion. Toyama K, etal., Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):616-25. doi: 10.1161/ATVBAHA.113.302440. Epub 2013 Dec 26.
57. p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1). Varela-Rey M, etal., FEBS Lett 2002 Sep 25;528(1-3):133-8.
58. Requirement for epithelial p38α in KRAS-driven lung tumor progression. Vitos-Faleato J, etal., Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2588-2596. doi: 10.1073/pnas.1921404117. Epub 2020 Jan 22.
59. Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis. Wakeman D, etal., Surgery. 2012 Aug;152(2):286-93. doi: 10.1016/j.surg.2012.05.009.
60. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, etal., J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15.
61. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
62. Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Woo CH and Kim JH, Mol Cells 2002 Jun 30;13(3):470-5.
63. Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. Wu D and Cederbaum AI, J Biol Chem 2003 Jan 10;278(2):1115-24.
64. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.
65. Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. Youssif C, etal., EMBO Mol Med. 2018 Jul;10(7). pii: emmm.201708403. doi: 10.15252/emmm.201708403.
66. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Zhang X, etal., J Biol Chem 2003 Jan 10;278(2):1248-58.
67. Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis. Zheng T, etal., Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12313-E12322. doi: 10.1073/pnas.1814705115. Epub 2018 Dec 12.
Additional References at PubMed
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Genomics

Comparative Map Data
Mapk14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl206,751,357 - 6,812,294 (+)EnsemblGRCr8
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)Ensemblrn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera208,305,853 - 8,366,371 (+)NCBICelera
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Cytogenetic Map20p12NCBI
MAPK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,027,808 - 36,124,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,027,738 - 36,122,511 (+)Ensemblhg38GRCh38
GRCh37635,995,585 - 36,079,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,103,551 - 36,186,513 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34636,103,550 - 36,186,513NCBI
Celera637,550,014 - 37,633,560 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,715,466 - 35,798,847 (+)NCBIHuRef
CHM1_1635,997,235 - 36,080,771 (+)NCBICHM1_1
T2T-CHM13v2.0635,848,088 - 35,944,528 (+)NCBIT2T-CHM13v2.0
Mapk14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,910,316 - 28,967,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,910,303 - 28,967,380 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381728,691,342 - 28,748,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,691,329 - 28,748,406 (+)Ensemblmm10GRCm38
MGSCv371728,828,287 - 28,885,350 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361728,419,034 - 28,475,994 (+)NCBIMGSCv36mm8
Celera1729,246,340 - 29,303,175 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.85NCBI
Mapk14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,838,232 - 3,884,083 (+)Ensembl
ChiLan1.0NW_0049554373,836,331 - 3,884,083 (+)NCBIChiLan1.0ChiLan1.0
MAPK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,493,097 - 50,588,368 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,363,113 - 46,457,826 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,586,847 - 35,683,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,788,233 - 36,871,114 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,788,233 - 36,871,114 (+)EnsemblpanPan2panpan1.1
MAPK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,145,647 - 5,221,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,146,037 - 5,220,603 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha125,166,000 - 5,239,239 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0125,493,681 - 5,569,596 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,493,440 - 5,569,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,148,463 - 5,221,682 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,227,753 - 5,300,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,327,755 - 5,400,924 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapk14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,650,066 - 40,722,468 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,237,277 - 23,310,232 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,237,762 - 23,310,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,877 - 31,862,031 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,012,164 - 36,095,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,014,454 - 36,095,138 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604435,975,418 - 36,065,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapk14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1185,112,956 - 5,172,783 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapk14
428 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir24-1rno-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19499150

Predicted Target Of
Summary Value
Count of predictions:1030
Count of miRNA genes:299
Interacting mature miRNAs:389
Transcripts:ENSRNOT00000000617, ENSRNOT00000000618
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH134442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,807,058 - 6,807,257 (+)MAPPERmRatBN7.2
Rnor_6.0205,991,611 - 5,991,809NCBIRnor6.0
Rnor_5.0208,025,182 - 8,025,380UniSTSRnor5.0
RGSC_v3.4206,996,847 - 6,997,045UniSTSRGSC3.4
Celera208,362,840 - 8,363,038UniSTS
RH 3.4 Map2077.1UniSTS
Cytogenetic Map20p12UniSTS
RH144423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,760,549 - 6,760,820 (+)MAPPERmRatBN7.2
Rnor_6.0205,944,184 - 5,944,454NCBIRnor6.0
Rnor_5.0207,979,420 - 7,979,690UniSTSRnor5.0
RGSC_v3.4206,950,132 - 6,950,402UniSTSRGSC3.4
Celera208,316,740 - 8,317,010UniSTS
RH 3.4 Map2077.8UniSTS
Cytogenetic Map20p12UniSTS
RH141341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,810,320 - 6,810,537 (+)MAPPERmRatBN7.2
Rnor_6.0205,994,868 - 5,995,084NCBIRnor6.0
Rnor_5.0208,028,439 - 8,028,655UniSTSRnor5.0
RGSC_v3.4207,000,109 - 7,000,325UniSTSRGSC3.4
Celera208,366,102 - 8,366,318UniSTS
RH 3.4 Map2076.7UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000617   ⟹   ENSRNOP00000000617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,359 - 6,812,294 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000000618   ⟹   ENSRNOP00000000618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,962 - 6,810,587 (+)Ensembl
Rnor_6.0 Ensembl205,933,595 - 5,995,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095202   ⟹   ENSRNOP00000080462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098053   ⟹   ENSRNOP00000090625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,808,890 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,807,186 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100696   ⟹   ENSRNOP00000082534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,804,704 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,803,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102158   ⟹   ENSRNOP00000096423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl206,751,357 - 6,812,293 (+)Ensembl
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)Ensembl
RefSeq Acc Id: NM_031020   ⟹   NP_112282
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,359 - 6,812,294 (+)NCBI
mRatBN7.2206,749,653 - 6,810,590 (+)NCBI
Rnor_6.0205,933,303 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
RGSC_v3.4206,939,249 - 7,000,378 (+)RGD
Celera208,305,853 - 8,366,371 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256142   ⟹   XP_006256204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,328 - 6,812,294 (+)NCBI
mRatBN7.2206,749,646 - 6,810,590 (+)NCBI
Rnor_6.0205,933,296 - 5,995,137 (+)NCBI
Rnor_5.0207,968,528 - 8,028,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279559   ⟹   XP_063135629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,751,288 - 6,808,890 (+)NCBI
RefSeq Acc Id: NP_112282   ⟸   NM_031020
- UniProtKB: Q56A33 (UniProtKB/TrEMBL),   A8C151 (UniProtKB/TrEMBL),   A0A8I5ZT48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256204   ⟸   XM_006256142
- Peptide Label: isoform X1
- UniProtKB: Q99MG4 (UniProtKB/Swiss-Prot),   P70618 (UniProtKB/Swiss-Prot),   O08594 (UniProtKB/Swiss-Prot),   G3V617 (UniProtKB/TrEMBL),   A6JJR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000617   ⟸   ENSRNOT00000000617
Ensembl Acc Id: ENSRNOP00000000618   ⟸   ENSRNOT00000000618
Ensembl Acc Id: ENSRNOP00000096423   ⟸   ENSRNOT00000102158
Ensembl Acc Id: ENSRNOP00000090625   ⟸   ENSRNOT00000098053
Ensembl Acc Id: ENSRNOP00000082534   ⟸   ENSRNOT00000100696
Ensembl Acc Id: ENSRNOP00000080462   ⟸   ENSRNOT00000095202
RefSeq Acc Id: XP_063135629   ⟸   XM_063279559
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZV37 (UniProtKB/TrEMBL),   A0A8I6AEN7 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70618-F1-model_v2 AlphaFold P70618 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701435
Promoter ID:EPDNEW_R11957
Type:initiation region
Name:Mapk14_1
Description:mitogen activated protein kinase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,933,300 - 5,933,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70496 AgrOrtholog
BioCyc Gene G2FUF-4407 BioCyc
Ensembl Genes ENSRNOG00000000513 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000617 ENTREZGENE
  ENSRNOT00000000618 ENTREZGENE
  ENSRNOT00000098053 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313217 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_p38-like UniProtKB/Swiss-Prot
  p38alpha UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
MGC_CLONE MGC:105413 IMAGE-MGC_LOAD
NCBI Gene 81649 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Mapk14 PhenoGen
PRINTS P38MAPKINASE UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000513 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZT48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL1_RAT UniProtKB/TrEMBL
  A6JJR8 ENTREZGENE, UniProtKB/TrEMBL
  A8C151 ENTREZGENE, UniProtKB/TrEMBL
  G3V617 ENTREZGENE, UniProtKB/TrEMBL
  MK14_RAT UniProtKB/Swiss-Prot
  O08594 ENTREZGENE
  P70618 ENTREZGENE
  Q56A33 ENTREZGENE, UniProtKB/TrEMBL
  Q99MG4 ENTREZGENE
UniProt Secondary O08594 UniProtKB/Swiss-Prot
  Q99MG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Mapk14  mitogen activated protein kinase 14    p38 mitogen activated protein kinase  Name updated 629478 APPROVED
2002-06-10 Mapk14  p38 mitogen activated protein kinase      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in heart ventricle 70317
gene_function phosphorylates and activates Mapkapk2 70317
gene_pathway estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process mediates hypertrophic agonist-induced GATA-4 binding and expression of B-type natriuretic peptide gene in cultured neonatal cardiac myocytes 625524
gene_process important for cytokine production 70317
gene_process important for cytokine production 70572
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70317
gene_process functions in stress related transcription and cell cycle regulation as well as in genotoxic stress response 70572
gene_product MAP kinase family member 70317
gene_regulation responds to changes in extracellular osmolarity 70572
gene_regulation responds to changes in extracellular osmolarity 625524
gene_regulation activated by estrogen in hippocampus, downregulated by ovariectomy 70572
gene_regulation activated by both receptor tyrosine kinase (RTK) and G protein-coupled receptor (GPCR) agonists 625519
gene_regulation activation requires NADH/NADPH-like oxidase activity in vascular smooth muscle cells (VSMC) 625519