Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14decreases phosphorylationISOMAPK14 (Homo sapiens)6480464CTDGlucose results in decreased phosphorylation of MAPK14 proteinPMID:20200188
Mapk14increases activityISOMAPK14 (Homo sapiens)6480464CTDGlucose deficiency results in increased activity of MAPK14 proteinPMID:17309078
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTDCAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK14 protein]; MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of CDH1 protein]; MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in decreased expression of KRT20 protein]; MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of ACTA2 protein]; MAPK14 protein promotes the reaction [[Glucose co-treated with TGFB1 protein] results in increased expression of VIM protein]; MAPK14 protein promotes the reaction [Glucose results in decreased expression of CDH1 protein]; MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 mRNA]; MAPK14 protein promotes the reaction [Glucose results in decreased expression of KRT20 protein]; MAPK14 protein promotes the reaction [Glucose results in increased expression of ACTA2 protein]; MAPK14 protein promotes the reaction [Glucose results in increased expression of SNAI1 mRNA]; MAPK14 protein promotes the reaction [Glucose results in increased expression of VIM mRNA]; MAPK14 protein promotes the reaction [Glucose results in increased secretion of FN1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Glucose deficiency results in increased activity of MAPK14 protein]PMID:17309078 PMID:21829520
Mapk14multiple interactionsISOMapk14 (Mus musculus)6480464CTD[resveratrol co-treated with Glucose] results in decreased expression of MAPK14 mRNA; Glucose promotes the reaction [EIF2AK2 protein results in increased activity of MAPK14 protein]PMID:18973755 PMID:24659233
Go Back to source page   Continue to Ontology report