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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MAPK14 mRNAPMID:33387578
Mapk14increases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of MAPK14 proteinPMID:23298284
Mapk14affects expressionISOMapk14 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MAPK14 mRNAPMID:21570461
Mapk14decreases expressionISOMAPK14 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MAPK14 mRNAPMID:20702593
Mapk14multiple interactionsISOMapk14 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of MAPK14 mRNAPMID:25975270
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