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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen activated protein kinase 14
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14increases phosphorylationISOMAPK14 (Homo sapiens)6480464CTDCisplatin results in increased phosphorylation of MAPK14 proteinPMID:37087747
Mapk14increases phosphorylationISOMapk14 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of MAPK14 proteinPMID:22006019 PMID:35304134 PMID:37087747
Mapk14multiple interactionsISOMapk14 (Mus musculus)6480464CTDmadecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein]; Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein]PMID:35304134 PMID:37087747
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