Keap1 (Kelch-like ECH-associated protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Keap1 (Kelch-like ECH-associated protein 1) Rattus norvegicus
Analyze
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
RGD ID: 621619
Description: Predicted to enable several functions, including disordered domain specific binding activity; transcription regulator inhibitor activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including response to immobilization stress; response to thyroid hormone; and selenium compound metabolic process. Located in adherens junction and focal adhesion. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2-tert-butylhydroquinone; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytosolic inhibitor of Nrf2; Inrf2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,044,555 - 28,054,042 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,044,555 - 28,054,042 (-)EnsemblGRCr8
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,161,976 - 21,171,435 (-)NCBICelera
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-ropivacaine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-di-tert-butylphenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-dipyridyl disulfide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (ISO)
Altertoxin II  (ISO)
amiodarone  (EXP)
amitraz  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
andrographolide  (ISO)
anethole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP)
aristolochic acid A  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
aureusidin  (EXP,ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
baicalin  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoquinones  (ISO)
betulin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bromosulfophthalein  (ISO)
Brusatol  (EXP,ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbendazim  (EXP)
carbon disulfide  (EXP)
carbon monoxide  (ISO)
carvedilol  (EXP)
CCCP  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
chalcones  (EXP)
CHIR 99021  (ISO)
chitosan  (EXP)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
Clivoline  (ISO)
clodronic acid  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dapagliflozin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
Dendrobine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetyl chloride  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
dimercaprol  (ISO)
dioscin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
diquat  (ISO)
disodium selenite  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
erastin  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
etoposide  (ISO)
falcarindiol  (EXP)
farnesol  (EXP)
farrerol  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
Forsythiaside  (ISO)
fumonisin B1  (ISO)
galactose  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
hemin  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hexaflumuron  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
hypoxanthine  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron(III) citrate  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
Liensinine  (ISO)
linderalactone  (ISO)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liproxstatin-1  (ISO)
liquiritin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (EXP,ISO)
methomyl  (EXP)
methotrexate  (EXP)
mevastatin  (ISO)
microcystin-LR  (ISO)
monascin  (ISO)
Monobutylphthalate  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene-1,2-diol  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP,ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perillyl aldehyde  (ISO)
phalloidin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
poly(ethylene)  (ISO)
poly(vinyl chloride)  (ISO)
porphyrins  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium dichromate  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (ISO)
quinolinic acid  (EXP)
reactive oxygen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
SCH772984  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silibinin  (EXP)
silicon atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
solanesol  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
T-2 toxin  (ISO)
tangeretin  (EXP)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
Timosaponin b ii  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
Torularhodin  (EXP)
trabectedin  (ISO)
trans-anethole  (EXP)
trans-piceid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trilobatin  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tyloxapol  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
wogonin  (EXP)
XAV939  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IEA,ISO)
adherens junction  (IDA)
Cul3-RING ubiquitin ligase complex  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
focal adhesion  (IDA)
inclusion body  (IEA,ISO,ISS)
midbody  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
protein-containing complex  (IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Blake DJ, etal., Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. Epub 2009 Jun 11.
2. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Dhakshinamoorthy S and Jaiswal AK, Oncogene 2001 Jun 28;20(29):3906-17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Goven D, etal., Thorax. 2008 Oct;63(10):916-24. Epub 2008 Jun 17.
5. Oxidative injury induces selective rather than global inhibition of proteasomal activity. Gurusamy N, etal., J Mol Cell Cardiol. 2008 Feb;44(2):419-28. Epub 2007 Oct 22.
6. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
7. The complexity of the Nrf2 pathway: beyond the antioxidant response. Huang Y, etal., J Nutr Biochem. 2015 Dec;26(12):1401-13. doi: 10.1016/j.jnutbio.2015.08.001. Epub 2015 Aug 8.
8. Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. Ikeda H, etal., Biochem J. 2004 Jun 1;380(Pt 2):515-21.
9. Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. Kim HJ and Vaziri ND, Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71. Epub 2009 Dec 9.
10. Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. Kim JH, etal., Free Radic Biol Med. 2012 Aug 1;53(3):629-40. Epub 2012 Apr 27.
11. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Kim JW, etal., Differentiation. 2007 Feb;75(2):147-57.
12. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Kong X, etal., Am J Respir Crit Care Med. 2011 Oct 15;184(8):928-38. Epub 2011 Jul 28.
13. Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease. Kurzawski M, etal., Environ Toxicol Pharmacol. 2012 Jul;34(1):87-95. Epub 2012 Mar 11.
14. Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. Mazur W, etal., APMIS. 2010 Sep 1;118(9):703-12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. Nguyen T, etal., J Biol Chem. 2005 Sep 16;280(37):32485-92. Epub 2005 Jul 6.
18. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound. Ohnuma T, etal., Toxicol Appl Pharmacol. 2010 Apr 1;244(1):27-36. Epub 2009 Dec 21.
19. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. Okada K, etal., J Gastroenterol. 2012 Aug;47(8):924-35. Epub 2012 Feb 28.
20. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Osburn WO, etal., Toxicol Sci. 2008 Jul;104(1):218-27. Epub 2008 Apr 15.
21. Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Palsamy P and Subramanian S, Biochim Biophys Acta. 2011 Jul;1812(7):719-31. Epub 2011 Mar 23.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). Rinaldi Tosi ME, etal., Cell Stress Chaperones. 2011 Jan;16(1):57-68. Epub 2010 Aug 24.
27. Ebselen, a seleno-organic antioxidant, as an electrophile. Sakurai T, etal., Chem Res Toxicol. 2006 Sep;19(9):1196-204.
28. Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis. Sarlette A, etal., J Neuropathol Exp Neurol. 2008 Nov;67(11):1055-62.
29. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Shibata T, etal., Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. Epub 2008 Jul 3.
30. Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion. Tanaka N, etal., Brain Res. 2011 Jan 25;1370:246-53. Epub 2010 Nov 11.
31. Keap1 in adhesion complexes. Velichkova M and Hasson T, Cell Motil Cytoskeleton. 2003 Oct;56(2):109-19.
32. Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning. Videla LA, etal., ScientificWorldJournal. 2012;2012:301494. Epub 2011 Dec 20.
33. Alterations in tumor biomarker GSTP gene methylation patterns induced by prenatal exposure to PFOS. Wan YJ, etal., Toxicology. 2010 Jul-Aug;274(1-3):57-64. Epub 2010 May 26.
34. Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCalpha and PI3K/AKT Signaling Pathways. Zhang Z, etal., J Agric Food Chem. 2012 Aug 9.
35. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Zhong Q, etal., Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3941-8. doi: 10.1167/iovs.13-11598.
Additional References at PubMed
PMID:9798653   PMID:11921171   PMID:12682069   PMID:14517290   PMID:14764898   PMID:15087497   PMID:15166316   PMID:15282312   PMID:15367669   PMID:15601839   PMID:15983046   PMID:16581765  
PMID:17015834   PMID:17468336   PMID:17982879   PMID:19424503   PMID:20133743   PMID:20173742   PMID:20421418   PMID:20452972   PMID:21703357   PMID:24211725   PMID:24796746   PMID:24796753  
PMID:25049078   PMID:25301875   PMID:25598205   PMID:26655811   PMID:27223823   PMID:27472294   PMID:27815660   PMID:28145852   PMID:29119264   PMID:29845199   PMID:30071128   PMID:30119254  
PMID:31273531   PMID:31355603   PMID:31432116   PMID:31563143   PMID:32590729   PMID:32894623   PMID:33760324   PMID:33777321   PMID:33811899   PMID:34185425   PMID:34278476   PMID:35026282  
PMID:36736873   PMID:37822721   PMID:38308640  


Genomics

Comparative Map Data
Keap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,044,555 - 28,054,042 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,044,555 - 28,054,042 (-)EnsemblGRCr8
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,161,976 - 21,171,435 (-)NCBICelera
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Cytogenetic Map8q13NCBI
KEAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,486,119 - 10,503,558 (-)Ensemblhg38GRCh38
GRCh371910,596,801 - 10,614,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
T2T-CHM13v2.01910,612,569 - 10,629,791 (-)NCBIT2T-CHM13v2.0
Keap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,141,026 - 21,150,628 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,141,026 - 21,150,657 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,229,730 - 21,239,361 (-)Ensemblmm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBIMGSCv36mm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.74NCBI
Keap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,704,695 - 1,711,290 (-)Ensembl
ChiLan1.0NW_0049554951,704,695 - 1,711,339 (-)NCBIChiLan1.0ChiLan1.0
KEAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,404,143 - 15,421,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,402,746 - 14,420,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,037,544 - 10,055,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,701,298 - 10,717,664 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,701,303 - 10,717,604 (-)EnsemblpanPan2panpan1.1
KEAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,651,070 - 50,661,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,650,711 - 50,658,496 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2050,523,052 - 50,533,206 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,174,558 - 51,182,077 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,164,570 - 51,185,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,380,711 - 50,390,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,808,833 - 50,818,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,049,891 - 51,060,051 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Keap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,560,465 - 209,569,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659782,340 - 793,688 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659785,059 - 793,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KEAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,276,336 - 69,294,382 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,280,940 - 69,290,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,634,153 - 69,643,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KEAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,515,789 - 9,526,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,515,416 - 9,522,797 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607410,471,467 - 10,484,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Keap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,580,812 - 2,595,023 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Keap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,492,211 - 17,501,358 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Keap1
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000028360
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH132242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,815 - 19,769,017 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,959 - 22,251,160NCBIRnor6.0
Rnor_5.0822,306,206 - 22,306,407UniSTSRnor5.0
RGSC_v3.4820,258,900 - 20,259,101UniSTSRGSC3.4
Celera821,162,417 - 21,162,618UniSTS
RH 3.4 Map8178.1UniSTS
Cytogenetic Map8q13UniSTS
RH142508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,776,593 - 19,776,733 (+)MAPPERmRatBN7.2
Rnor_6.0822,258,734 - 22,258,873NCBIRnor6.0
Rnor_5.0822,313,981 - 22,314,120UniSTSRnor5.0
RGSC_v3.4820,266,678 - 20,266,817UniSTSRGSC3.4
Celera821,170,167 - 21,170,306UniSTS
RH 3.4 Map8205.19UniSTS
Cytogenetic Map8q13UniSTS
RH137423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,769,609 - 19,769,792 (+)MAPPERmRatBN7.2
Rnor_6.0822,251,753 - 22,251,935NCBIRnor6.0
Rnor_5.0822,307,000 - 22,307,182UniSTSRnor5.0
RGSC_v3.4820,259,694 - 20,259,876UniSTSRGSC3.4
Celera821,163,211 - 21,163,393UniSTS
Cytogenetic Map8q13UniSTS
RH138725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,772,493 - 19,772,668 (+)MAPPERmRatBN7.2
Rnor_6.0822,254,636 - 22,254,810NCBIRnor6.0
Rnor_5.0822,309,883 - 22,310,057UniSTSRnor5.0
RGSC_v3.4820,262,578 - 20,262,752UniSTSRGSC3.4
Celera821,166,069 - 21,166,243UniSTS
Cytogenetic Map8q13UniSTS
RH138813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,411 - 19,768,587 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,555 - 22,250,730NCBIRnor6.0
Rnor_5.0822,305,802 - 22,305,977UniSTSRnor5.0
RGSC_v3.4820,258,496 - 20,258,671UniSTSRGSC3.4
Celera821,162,013 - 21,162,188UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028360   ⟹   ENSRNOP00000028360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,044,555 - 28,054,042 (-)Ensembl
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)Ensembl
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101216   ⟹   ENSRNOP00000081740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,768,692 - 19,777,333 (-)Ensembl
RefSeq Acc Id: NM_057152   ⟹   NP_476493
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,555 - 28,054,042 (-)NCBI
mRatBN7.2819,768,375 - 19,777,862 (-)NCBI
Rnor_6.0822,250,518 - 22,259,779 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
RGSC_v3.4820,259,178 - 20,266,351 (-)RGD
Celera821,161,976 - 21,171,435 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242591   ⟹   XP_006242653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,874 - 28,053,907 (-)NCBI
mRatBN7.2819,768,694 - 19,777,726 (-)NCBI
Rnor_6.0822,250,521 - 22,259,868 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080715   ⟹   XP_038936643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,874 - 28,053,625 (-)NCBI
mRatBN7.2819,768,694 - 19,777,444 (-)NCBI
RefSeq Acc Id: NP_476493   ⟸   NM_057152
- UniProtKB: G3V8U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242653   ⟸   XM_006242591
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028360   ⟸   ENSRNOT00000028360
RefSeq Acc Id: XP_038936643   ⟸   XM_039080715
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081740   ⟸   ENSRNOT00000101216
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P57790-F1-model_v2 AlphaFold P57790 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621619 AgrOrtholog
BioCyc Gene G2FUF-31432 BioCyc
Ensembl Genes ENSRNOG00000020878 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028360 ENTREZGENE
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  KEAP1 UniProtKB/Swiss-Prot
  KEAP1_BACK UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
NCBI Gene 117519 ENTREZGENE
PANTHER KELCH-LIKE PROTEIN 26 UniProtKB/Swiss-Prot
  LD33804P UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  Kelch_KLHDC2_KLHL20_DRC7 UniProtKB/Swiss-Prot
PhenoGen Keap1 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020878 RatGTEx
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A0A8I5ZVM9 ENTREZGENE
  A6JNQ1 ENTREZGENE, UniProtKB/TrEMBL
  G3V8U2 ENTREZGENE, UniProtKB/TrEMBL
  KEAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9ERI3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs releases Nrf2 following administration of antioxidants and xenobiotics 727319
gene_process involved in repression of Antioxidant response element (ARE)-mediated NQO1 gene expression 727319