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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1decreases response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein results in decreased susceptibility to EtoposidePMID:22684020
Keap1increases response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 mRNA results in increased susceptibility to EtoposidePMID:26708503
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]PMID:27982581
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