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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of KEAP1 proteinPMID:24634002 PMID:32920515
Keap1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of KEAP1 mRNAPMID:29223816
Keap1multiple interactionsEXP 6480464CTDcrocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]PMID:32920515
Keap1affects response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 gene mutant form affects the susceptibility to Arsenic TrioxidePMID:30815697
Keap1decreases response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 protein results in decreased susceptibility to Arsenic TrioxidePMID:22684020
Keap1increases expressionISOKEAP1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of KEAP1 mRNA; Arsenic Trioxide results in increased expression of KEAP1 proteinPMID:15894607 PMID:19417148 PMID:22684020
Keap1increases expressionISOKeap1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of KEAP1 proteinPMID:33846815
Keap1increases response to substanceISOKEAP1 (Homo sapiens)6480464CTDKEAP1 mRNA results in increased susceptibility to Arsenic TrioxidePMID:26708503
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTD[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA; Arsenic Trioxide affects the reaction [KEAP1 protein results in increased expression of CCND1 protein]; KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to Arsenic Trioxide]; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of CCND1 mRNA]; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of PPARG mRNA]; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of PPARG protein]; KEAP1 protein promotes the reaction [Rosiglitazone results in increased susceptibility to Arsenic Trioxide]; KEAP1 protein promotes the reaction [Troglitazone results in increased susceptibility to Arsenic Trioxide]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein]PMID:15894607 PMID:22684020 PMID:26708503
Keap1multiple interactionsISOKeap1 (Mus musculus)6480464CTD18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein]PMID:33846815
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