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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1affects expressionEXP 6480464CTDsodium arsenite affects the expression of KEAP1 mRNAPMID:25625412
Keap1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of KEAP1PMID:24062023
Keap1multiple interactionsEXP 6480464CTDsilybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1]PMID:24062023
Keap1affects foldingISOKeap1 (Mus musculus)6480464CTDsodium arsenite affects the folding of KEAP1 proteinPMID:30261176
Keap1affects localizationISOKEAP1 (Homo sapiens)6480464CTDsodium arsenite affects the localization of KEAP1 proteinPMID:23589329
Keap1decreases expressionISOKEAP1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of KEAP1 proteinPMID:26409248 PMID:28229933
Keap1increases expressionISOKeap1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of KEAP1 mRNA; sodium arsenite results in increased expression of KEAP1 proteinPMID:26371860 PMID:35679981
Keap1increases methylationISOKEAP1 (Homo sapiens)6480464CTDsodium arsenite results in increased methylation of KEAP1 promoterPMID:26409248
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTDDecitabine inhibits the reaction [sodium arsenite results in decreased expression of KEAP1 protein]; Decitabine inhibits the reaction [sodium arsenite results in increased methylation of KEAP1 promoter]; KEAP1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein]; sodium arsenite inhibits the reaction [KEAP1 protein mutant form results in increased ubiquitination of NFE2L2 protein]; sodium arsenite inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; sodium arsenite promotes the reaction [KEAP1 protein binds to CUL3 protein]; sodium arsenite promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; sulforaphane inhibits the reaction [sodium arsenite affects the localization of KEAP1 protein]PMID:18417180 PMID:23589329 PMID:26409248
Keap1multiple interactionsISOKeap1 (Mus musculus)6480464CTDATG7 gene mutant form inhibits the reaction [sodium arsenite results in increased degradation of KEAP1 protein]; sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]; sodium arsenite promotes the reaction [KEAP1 protein binds to KEAP1 protein]; sodium arsenite promotes the reaction [SQSTM1 protein binds to KEAP1 protein]PMID:16785233 PMID:26483381 PMID:30261176
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