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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1affects metabolic processingISOKeap1 (Mus musculus)6480464CTDDinitrochlorobenzene affects the metabolism of KEAP1 proteinPMID:18785192
Keap1decreases expressionISOKeap1 (Mus musculus)6480464CTDDinitrochlorobenzene results in decreased expression of KEAP1 mRNAPMID:28219650
Keap1increases expressionISOKEAP1 (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased expression of KEAP1 proteinPMID:19033392
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]; Dinitrochlorobenzene promotes the reaction [KEAP1 protein binds to KEAP1 protein]; tetrachlorobenzoquinone promotes the reaction [Dinitrochlorobenzene promotes the reaction [KEAP1 protein binds to KEAP1 protein]]PMID:19033392 PMID:25742418
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