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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:28830
Term: chlorambucil
Definition: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Chemical ID: MESH:D002699
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTD[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]PMID:19608619
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