Top2a (DNA topoisomerase II alpha) - Rat Genome Database

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Gene: Top2a (DNA topoisomerase II alpha) Rattus norvegicus
Analyze
Symbol: Top2a
Name: DNA topoisomerase II alpha
RGD ID: 62048
Description: Enables several functions, including ATP binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA topoisomerase II alpha); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,441,954 - 84,473,366 (-)EnsemblGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)Ensemblrn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,687,594 - 82,716,976 (-)NCBICelera
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9,10-phenanthroquinone  (ISO)
9-hydroxyellipticine  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
altenusin  (ISO)
alternariol  (ISO)
Altertoxin I  (ISO)
Altertoxin II  (ISO)
amsacrine  (ISO)
anthracenes  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
aurofusarin  (ISO)
azathioprine  (ISO)
barium sulfate  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Boswellic acid  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captafol  (ISO)
captan  (ISO)
Carbadox  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorendic acid  (EXP)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
Cryptotanshinone  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
GW 7647  (ISO)
Heliotrine  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypericin  (ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (ISO)
lucanthone  (ISO)
Macrosporin  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mycotoxin  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene-1,2-diol  (ISO)
nevadensin  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
Nitidine  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
orotic acid  (EXP)
oxaliplatin  (EXP)
oxfendazole  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pectolinarigenin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
propiconazole  (ISO)
Pyrenophorol  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
razoxane  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Stemphyltoxin III  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
tremolite asbestos  (ISO)
triacsin C  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
Xanthatin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. Albadine R, etal., J Urol. 2009 Aug;182(2):735-40. Epub 2009 Jun 18.
2. Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays. Baker VA, etal., Environ Health Perspect. 2004 Mar;112(4):428-38.
3. Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha. Bakshi R, etal., J Biomol Struct Dyn. 2001 Apr;18(5):749-60.
4. DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity. Berney DM, etal., BJU Int. 2008 Sep;102(8):1040-4. Epub 2008 May 16.
5. Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia. Bethel CR, etal., Prostate. 2009 Jun 1;69(8):838-50.
6. Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase IIalpha and active caspase-3. Coelho RA, etal., Eur J Gynaecol Oncol. 2008;29(5):499-501.
7. Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Faggad A, etal., Mod Pathol. 2009 Apr;22(4):579-88. Epub 2009 Mar 6.
8. The expression of the nuclear matrix proteins NuMA, topoisomerase II-alpha, and -beta in bone and osseous cell culture: regulation by parathyroid hormone. Feister HA, etal., Bone. 2000 Mar;26(3):227-34.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Glucose-regulated protein 75 overexpression attenuates ionizing radiation-mediated injury in PC12 cells by inducing the expression of topoisomerase IIa. Guo W, etal., Mol Med Rep. 2012 Dec;6(6):1423-7. doi: 10.3892/mmr.2012.1070. Epub 2012 Sep 10.
11. Clinical Implications and Prognostic Values of Topoisomerase-II Alpha Expression in Primary Non-Muscle-Invasive Bladder Cancer. Kim EJ, etal., Urology. 2009 Nov 12.
12. Identification of prognostic biomarkers for prostate cancer. Kosari F, etal., Clin Cancer Res. 2008 Mar 15;14(6):1734-43.
13. Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy. Martin CM, etal., Methods Mol Biol. 2009;511:333-59.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Structural homology between molecular probes binding site of DNA polymerase beta and DNA topoisomerase II Mizushina Y, etal., Tanpakushitsu Kakusan Koso 2002 May;47(6):708-14.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D. Nielsen KV, etal., Acta Oncol. 2008;47(4):725-34.
18. Nucleotide sequence analysis of the CDNA for rat DNA topoisomerase II. Park SH, etal., Biochem Biophys Res Commun 1993 Jun 15;193(2):787-93.
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms. Rochette L, etal., Trends Pharmacol Sci. 2015 Jun;36(6):326-48. doi: 10.1016/j.tips.2015.03.005. Epub 2015 Apr 17.
24. Topoisomerase IIalpha expression in ductal carcinoma in situ of the breast: a preliminary study. Shpitz B, etal., Hum Pathol. 2000 Oct;31(10):1249-54.
25. Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer. Sparano JA, etal., Clin Cancer Res. 2009 Dec 15;15(24):7693-7700. Epub .
26. Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features. Takahashi M, etal., Cancer Res. 2002 Nov 15;62(22):6598-605.
27. Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression. Tretiakova M, etal., J Clin Pathol. 2006 Dec;59(12):1272-7. Epub 2006 Mar 23.
28. Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum. Tsutsui K, et al., J Comp Neurol. 2001 Mar 5;431(2):228-39.
29. Molecular cloning of partial cDNAs for rat DNA topoisomerase II isoforms and their differential expression in brain development. Tsutsui K, etal., J Biol Chem 1993 Sep 5;268(25):19076-83.
30. Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts. Usha L, etal., J Hematol Oncol. 2008 Aug 14;1:12.
31. Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain. Watanabe M, et al., Neurosci Res. 1994 Feb;19(1):51-7.
32. Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Yamauchi H, etal., Biol Reprod. 2004 Jun;70(6):1762-7. Epub 2004 Feb 6.
Additional References at PubMed
PMID:1331984   PMID:1683482   PMID:7842491   PMID:7937150   PMID:9049244   PMID:9094096   PMID:9224616   PMID:10473615   PMID:10666337   PMID:10788521   PMID:10959840   PMID:11062478  
PMID:11136718   PMID:11835579   PMID:11835580   PMID:12079377   PMID:12711669   PMID:15013075   PMID:15456904   PMID:15491148   PMID:15965487   PMID:16611985   PMID:16712776   PMID:16914642  
PMID:17567603   PMID:21795393   PMID:22323612   PMID:22681889   PMID:23012366   PMID:24029230   PMID:24116135   PMID:24321095   PMID:24625528   PMID:25961503   PMID:26319574   PMID:26527691  
PMID:30053369   PMID:31505169   PMID:35352799  


Genomics

Comparative Map Data
Top2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1084,441,954 - 84,473,366 (-)EnsemblGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)Ensemblrn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1082,687,594 - 82,716,976 (-)NCBICelera
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Cytogenetic Map10q31NCBI
TOP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,388,525 - 40,417,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,388,525 - 40,417,896 (-)Ensemblhg38GRCh38
GRCh371738,544,777 - 38,574,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,798,321 - 35,827,695 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341735,798,320 - 35,827,695NCBI
Celera1735,204,916 - 35,234,352 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,337,633 - 34,367,123 (-)NCBIHuRef
CHM1_11738,780,085 - 38,809,522 (-)NCBICHM1_1
T2T-CHM13v2.01741,252,019 - 41,281,395 (-)NCBIT2T-CHM13v2.0
Top2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,883,773 - 98,915,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)Ensemblmm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBIMGSCv36mm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
Top2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,929,136 - 14,964,723 (-)Ensembl
ChiLan1.0NW_00495545114,928,273 - 14,964,855 (-)NCBIChiLan1.0ChiLan1.0
TOP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,537,882 - 24,567,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,432,885 - 26,462,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,872,169 - 16,901,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,097,619 - 17,127,195 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,097,778 - 17,126,207 (+)EnsemblpanPan2panpan1.1
TOP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,207,501 - 22,237,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,207,638 - 22,237,496 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha921,679,941 - 21,709,943 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0923,000,244 - 23,030,254 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,000,269 - 23,029,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,774,298 - 21,804,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,033,150 - 22,063,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,157,897 - 22,187,909 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Top2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,608,163 - 21,633,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,441,575 - 15,466,978 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,441,463 - 15,465,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,001,282 - 22,028,450 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11222,001,300 - 22,028,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,310,214 - 22,337,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,761,391 - 65,792,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1955,420,581 - 55,451,553 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Top2a
373 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:86
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000050725
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC207566P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,959,743 - 83,960,392 (+)MAPPERmRatBN7.2
Rnor_6.01086,914,986 - 86,915,634NCBIRnor6.0
Rnor_5.01086,712,635 - 86,713,283UniSTSRnor5.0
RGSC_v3.41087,784,898 - 87,785,546UniSTSRGSC3.4
Celera1082,701,028 - 82,701,676UniSTS
Cytogenetic Map10q31UniSTS
RH128311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,945,870 - 83,946,082 (+)MAPPERmRatBN7.2
Rnor_6.01086,901,152 - 86,901,363NCBIRnor6.0
Rnor_5.01086,698,962 - 86,699,173UniSTSRnor5.0
RGSC_v3.41087,771,022 - 87,771,233UniSTSRGSC3.4
Celera1082,687,279 - 82,687,490UniSTS
RH 3.4 Map10874.8UniSTS
Cytogenetic Map10q31UniSTS
PMC207566P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,976,767 - 83,976,982 (+)MAPPERmRatBN7.2
Rnor_6.01086,932,021 - 86,932,235NCBIRnor6.0
Rnor_5.01086,729,384 - 86,729,598UniSTSRnor5.0
RGSC_v3.41087,802,034 - 87,802,248UniSTSRGSC3.4
Celera1082,718,050 - 82,718,264UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000081440   ⟹   ENSRNOP00000069083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,945,908 - 83,975,696 (-)Ensembl
Rnor_6.0 Ensembl1086,901,467 - 86,930,947 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085344   ⟹   ENSRNOP00000069963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,441,954 - 84,473,093 (-)Ensembl
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)Ensembl
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096403   ⟹   ENSRNOP00000091216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1084,441,954 - 84,473,366 (-)Ensembl
mRatBN7.2 Ensembl1083,945,735 - 83,976,744 (-)Ensembl
RefSeq Acc Id: NM_001393768   ⟹   NP_001380697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81084,441,954 - 84,473,093 (-)NCBI
mRatBN7.21083,945,731 - 83,976,874 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380697 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA03132 (Get FASTA)   NCBI Sequence Viewer  
  CAA79611 (Get FASTA)   NCBI Sequence Viewer  
  EDM05966 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091216
GenBank Protein P41516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000069963   ⟸   ENSRNOT00000085344
Ensembl Acc Id: ENSRNOP00000069083   ⟸   ENSRNOT00000081440
Ensembl Acc Id: ENSRNOP00000091216   ⟸   ENSRNOT00000096403
RefSeq Acc Id: NP_001380697   ⟸   NM_001393768
- UniProtKB: A0A0G2JWP8 (UniProtKB/TrEMBL),   A6HIW1 (UniProtKB/TrEMBL),   A0A8I6ADA9 (UniProtKB/TrEMBL)
Protein Domains
Topo IIA-type catalytic   Toprim

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41516-F1-model_v2 AlphaFold P41516 1-1526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697681
Promoter ID:EPDNEW_R8199
Type:multiple initiation site
Name:Top2a_1
Description:DNA topoisomerase II alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,932,115 - 86,932,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62048 AgrOrtholog
BioCyc Gene G2FUF-23330 BioCyc
Ensembl Genes ENSRNOG00000053047 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000096403 ENTREZGENE
Gene3D-CATH 1.10.268.10 UniProtKB/Swiss-Prot
  3.30.1360.40 UniProtKB/Swiss-Prot
  3.30.1490.30 UniProtKB/Swiss-Prot
  3.30.230.10 UniProtKB/Swiss-Prot
  3.30.565.10 UniProtKB/Swiss-Prot
  3.40.50.670 UniProtKB/Swiss-Prot
  3.90.199.10 UniProtKB/Swiss-Prot
InterPro DNA_Topoisomerase_II UniProtKB/Swiss-Prot
  DTHCT UniProtKB/Swiss-Prot
  HATPase_C_sf UniProtKB/Swiss-Prot
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/Swiss-Prot
  Topo_IIA UniProtKB/Swiss-Prot
  Topo_IIA-like_dom_sf UniProtKB/Swiss-Prot
  Topo_IIA_A/C UniProtKB/Swiss-Prot
  Topo_IIA_A/C_ab UniProtKB/Swiss-Prot
  Topo_IIA_A_a_sf UniProtKB/Swiss-Prot
  Topo_IIA_B_C UniProtKB/Swiss-Prot
  Topo_IIA_bsu_dom2 UniProtKB/Swiss-Prot
  TopoII_euk UniProtKB/Swiss-Prot
  TopoIIA_CS UniProtKB/Swiss-Prot
  TOPRIM_C UniProtKB/Swiss-Prot
  TOPRIM_domain UniProtKB/Swiss-Prot
  TOPRIM_TopoII UniProtKB/Swiss-Prot
NCBI Gene 360243 ENTREZGENE
PANTHER DNA TOPOISOMERASE 2-ALPHA UniProtKB/Swiss-Prot
  DNA TOPOISOMERASE/GYRASE UniProtKB/Swiss-Prot
Pfam DNA_gyraseB UniProtKB/Swiss-Prot
  DNA_topoisoIV UniProtKB/Swiss-Prot
  DTHCT UniProtKB/Swiss-Prot
  HATPase_c UniProtKB/Swiss-Prot
  Toprim UniProtKB/Swiss-Prot
  TOPRIM_C UniProtKB/Swiss-Prot
PharmGKB TOP2A RGD
PhenoGen Top2a PhenoGen
PRINTS TOPISMRASEII UniProtKB/Swiss-Prot
  TPI2FAMILY UniProtKB/Swiss-Prot
PROSITE TOPO_IIA UniProtKB/Swiss-Prot
  TOPOISOMERASE_II UniProtKB/Swiss-Prot
  TOPRIM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053047 RatGTEx
SMART TOP2c UniProtKB/Swiss-Prot
  TOP4c UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot
  SSF55874 UniProtKB/Swiss-Prot
  SSF56719 UniProtKB/Swiss-Prot
UniProt A0A0G2JWP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HIW1 ENTREZGENE, UniProtKB/TrEMBL
  P41516 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top2a  DNA topoisomerase II alpha  Top2a  topoisomerase (DNA) II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-28 Top2a  topoisomerase (DNA) II alpha  Top2a  topoisomerase (DNA) 2 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Top2a  topoisomerase (DNA) 2 alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Top2a  topoisomerase (DNA) 2 alpha      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains conains three functional domains for ATPase activity, DNA break-reunion activity and DNA binding activity, as well as a leucine zipper motif and two putative nuclear targeting sequences 61772
gene_protein putative protein consists of 1526 aa residues 61772