TOP2A (DNA topoisomerase II alpha) - Rat Genome Database

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Gene: TOP2A (DNA topoisomerase II alpha) Chlorocebus sabaeus
Analyze
Symbol: TOP2A
Name: DNA topoisomerase II alpha
RGD ID: 18684932
Description: ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN cerebellar granule cell differentiation (ortholog); cerebellar Purkinje cell differentiation (ortholog); chromosome condensation (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex (ortholog); nucleolus (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 2-alpha; topoisomerase (DNA) II alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,761,391 - 65,792,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,761,391 - 65,792,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TOP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,388,525 - 40,417,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,388,525 - 40,417,896 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,544,777 - 38,574,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,798,321 - 35,827,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,798,320 - 35,827,695NCBI
Celera1735,204,916 - 35,234,352 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,337,633 - 34,367,123 (-)NCBIHuRef
CHM1_11738,780,085 - 38,809,522 (-)NCBICHM1_1
T2T-CHM13v2.01741,252,019 - 41,281,395 (-)NCBIT2T-CHM13v2.0
Top2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,883,773 - 98,915,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,883,769 - 98,915,015 (-)EnsemblGRCm39 Ensembl
GRCm381198,992,947 - 99,024,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,992,943 - 99,024,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,854,261 - 98,885,503 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,809,493 - 98,840,205 (-)NCBIMGSCv36mm8
Celera11108,658,802 - 108,690,006 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.91NCBI
Top2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,441,954 - 84,473,093 (-)NCBIGRCr8
mRatBN7.21083,945,731 - 83,976,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,945,735 - 83,976,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,889,659 - 88,920,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,387,764 - 88,418,905 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,780,312 - 83,811,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,901,007 - 86,932,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBICelera
Cytogenetic Map10q31NCBI
Top2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,929,136 - 14,964,723 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,928,273 - 14,964,855 (-)NCBIChiLan1.0ChiLan1.0
TOP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,537,882 - 24,567,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,432,885 - 26,462,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,872,169 - 16,901,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,097,619 - 17,127,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,097,778 - 17,126,207 (+)Ensemblpanpan1.1panPan2
TOP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,207,501 - 22,237,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,207,638 - 22,237,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,679,941 - 21,709,943 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,000,244 - 23,030,254 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,000,269 - 23,029,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,774,298 - 21,804,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,033,150 - 22,063,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,157,897 - 22,187,909 (+)NCBIUU_Cfam_GSD_1.0
Top2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,608,163 - 21,633,139 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,441,575 - 15,466,978 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,441,463 - 15,465,692 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,001,282 - 22,028,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,001,300 - 22,028,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,310,214 - 22,337,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2 2 2
Low 34 18 58
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008012789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000000809   ⟹   ENSCSAP00000015255
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1665,761,416 - 65,792,701 (+)Ensembl
RefSeq Acc Id: XM_008012789   ⟹   XP_008010980
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11665,761,391 - 65,792,041 (+)NCBI
Vero_WHO_p1.0NW_02366607736,662,555 - 36,693,082 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008010980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015255
  ENSCSAP00000015255.1
Reference Protein Sequences
RefSeq Acc Id: XP_008010980   ⟸   XM_008012789
- UniProtKB: A0A0D9S316 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015255   ⟸   ENSCSAT00000000809


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002790 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000809.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.268.10 UniProtKB/TrEMBL
  3.30.1360.40 UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/TrEMBL
  3.90.199.10 UniProtKB/TrEMBL
InterPro DTHCT UniProtKB/TrEMBL
  HATPase_C UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Topo_IIA UniProtKB/TrEMBL
  Topo_IIA-like_dom_sf UniProtKB/TrEMBL
  Topo_IIA_A/C UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/TrEMBL
  Topo_IIA_A_a_sf UniProtKB/TrEMBL
  Topo_IIA_B_C UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/TrEMBL
  TopoII_euk UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/TrEMBL
KEGG Report csab:103243514 UniProtKB/TrEMBL
NCBI Gene TOP2A ENTREZGENE
PANTHER DNA TOPOISOMERASE 2-ALPHA UniProtKB/TrEMBL
  DNA TOPOISOMERASE/GYRASE UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
PRINTS TOPISMRASEII UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_II UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
SMART TOP2c UniProtKB/TrEMBL
  TOP4c UniProtKB/TrEMBL
Superfamily-SCOP SSF54211 UniProtKB/TrEMBL
  SSF55874 UniProtKB/TrEMBL
  SSF56719 UniProtKB/TrEMBL
UniProt A0A0D9S316 ENTREZGENE, UniProtKB/TrEMBL