DOXORUBICIN PHARMACODYNAMICS PATHWAY (PW:0001566)

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Description

Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius. DOX is used in the treatment of several solid cancers, leukemia and lymphomas. The drug is composed of a planar aromatic ring with an anthraquinone chromophore and a sugar group. Once taken up by the cell and inside the nucleus for which it has a high affinity, the planar ring structure intercalates between adjacent DNA base pairs, preferentia

Pathway Diagram:

Elsevier Inc. DNA replication pathway DNA transcription pathway Top2b Top2a DOX adducts doxorubicin --+> intrinsic apoptotic pathway doxorubicin --+> doxorubicin response pathway doxorubicin response pathway doxorubicin ---- Top2b doxorubicin ---- Top2a doxorubicin ---| DNA replication pathway doxorubicin ---| DNA transcription pathway doxorubicin doxorubicin ---| cancer cells cancer cells intrinsic apoptotic pathway p53 signaling pathway doxorubicin --+> p53 signaling pathway
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Genes in Pathway:

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doxorubicin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Top2a topoisomerase (DNA) II alpha JBrowse link 10 86,901,467 86,930,947 RGD:10395260
G Top2b topoisomerase (DNA) II beta JBrowse link 15 10,262,972 10,319,741 RGD:10395260

Pathway Gene Annotations

Disease Annotations Associated with Genes in the doxorubicin pharmacodynamics pathway
Pathway Annotations Associated with Genes in the doxorubicin pharmacodynamics pathway

References Associated with the doxorubicin pharmacodynamics pathway:

Ontology Path Diagram:

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