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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048 Species: Rattus norvegicus RGD Object: Gene Symbol: Top2a Name: topoisomerase (DNA) II alpha

Acc ID: CHEBI:15422 Term: ATP Definition: A purine ribonucleoside 5'-triphosphate that has formula C10H16N5O13P3. CasRN: 56-65-5 Chemical ID: MESH:D000255

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352729	6480464	CTD	Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]	PMID:20855424
increases hydrolysis	ISO	RGD:1352729	6480464	CTD	TOP2A results in increased hydrolysis of Adenosine Triphosphate	PMID:20855424