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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2aincreases expressionEXP 6480464CTDPhenobarbital results in increased expression of TOP2A mRNAPMID:19162173
Top2aincreases expressionISOTop2a (Mus musculus)6480464CTDPhenobarbital results in increased expression of TOP2A mRNAPMID:19363144 PMID:19482888 PMID:23091169
Top2amultiple interactionsISOTop2a (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOP2A mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TOP2A mRNA]PMID:19482888 PMID:24535843
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