Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	62048
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Top2a
Name:	DNA topoisomerase II alpha

Acc ID:	CHEBI:49603
Term:	lapatinib
Definition:	A furan that has formula C29H26ClFN4O4S.
Chemical ID:	MESH:C490728

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Top2a	decreases expression	ISO	TOP2A (Homo sapiens)	6480464	CTD	Lapatinib results in decreased expression of TOP2A protein	PMID:37788138

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.