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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2adecreases expressionISOTOP2A (Homo sapiens)6480464CTDFluorouracil results in decreased expression of TOP2A mRNAPMID:15205334 PMID:16557594
Top2adecreases expressionISOTop2a (Mus musculus)6480464CTDFluorouracil results in decreased expression of TOP2A mRNAPMID:19272435
Top2amultiple interactionsISOTOP2A (Homo sapiens)6480464CTDTOP2A protein affects the susceptibility to [Cyclophosphamide co-treated with Epirubicin co-treated with Fluorouracil]; TOP2A protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]; TP53 protein affects the reaction [Fluorouracil results in decreased expression of TOP2A mRNA]PMID:15016801 PMID:16682728 PMID:18465341
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