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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:100241
Term: ciprofloxacin
Definition: A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Chemical ID: MESH:D002939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2aaffects bindingISOTOP2A (Homo sapiens)6480464CTDCiprofloxacin binds to TOP2A proteinPMID:21413765
Top2amultiple interactionsISOTOP2A (Homo sapiens)6480464CTD[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]PMID:21413765
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