Daxx (death-domain associated protein) - Rat Genome Database

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Gene: Daxx (death-domain associated protein) Rattus norvegicus
Analyze
Symbol: Daxx
Name: death-domain associated protein
RGD ID: 621227
Description: Enables JUN kinase binding activity; kinesin binding activity; and nuclear androgen receptor binding activity. Involved in several processes, including PML body organization; cellular response to cytokine stimulus; and cellular response to hydrogen peroxide. Located in several cellular components, including PML body; XY body; and microtubule. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein); PARTICIPATES IN aldosterone signaling pathway; histone modification pathway; p53 signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death domain-associated protein 6; Fas death domain-associated protein; MGC156601
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,971,973 - 4,978,062 (-)NCBIGRCr8
mRatBN7.2204,970,090 - 4,976,145 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,970,092 - 4,975,843 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,693,494 - 5,699,246 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,055,239 - 5,060,991 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,535,985 - 5,541,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,480,103 - 5,485,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,480,103 - 5,485,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,538,715 - 7,544,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,121,854 - 5,127,601 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,122,244 - 5,126,875 (-)NCBI
Celera206,554,093 - 6,559,840 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
cladribine  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
ellagic acid  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP)
olmesartan  (ISO)
oxybenzone  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IEA,ISO)
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
cell population proliferation  (ISO)
cellular response to cadmium ion  (IEA,ISO,ISS)
cellular response to copper ion  (IEA,ISO,ISS)
cellular response to diamide  (IEA,ISO,ISS)
cellular response to heat  (IEA,ISO,ISS)
cellular response to hydrogen peroxide  (IEP)
cellular response to sodium arsenite  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IMP)
cellular response to unfolded protein  (IEA,ISO,ISS)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
JNK cascade  (IEA,ISO)
mitotic cytokinesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of DNA-templated transcription  (IBA,IEA,ISO)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of myotube differentiation  (IDA)
negative regulation of protein kinase activity  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
neuron intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
nucleosome assembly  (IBA,IEA,ISO)
PML body organization  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of protein kinase activity  (IMP)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to chromatin  (ISO)
regulation of apoptotic process  (IBA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of protein ubiquitination  (IEA,ISO,ISS)
response to metal ion  (IEP)

Cellular Component
cell body  (IDA)
cell cortex  (IDA)
chromosome, centromeric region  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (ISO,ISS)
heterochromatin  (ISO)
microtubule  (IDA)
nuclear body  (ISO)
nucleolus  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,ISO,ISS)
PML body  (IDA,IEA,ISO,ISS)
XY body  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Bi FF, etal., Brain Res. 2008 Jan 29;1191:30-8. Epub 2007 Nov 12.
2. Histone chaperones in nucleosome assembly and human disease. Burgess RJ and Zhang Z, Nat Struct Mol Biol. 2013 Jan;20(1):14-22. doi: 10.1038/nsmb.2461.
3. Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer. Chen C, etal., Cell Death Dis. 2020 Jul 8;11(7):514. doi: 10.1038/s41419-020-2718-3.
4. Clinicopathologic significance of immunostaining of alpha-thalassemia/mental retardation syndrome X-linked protein and death domain-associated protein in neuroendocrine tumors. Chen SF, etal., Hum Pathol. 2013 Oct;44(10):2199-203. doi: 10.1016/j.humpath.2013.04.025. Epub 2013 Aug 16.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Assessment of pancreatic neuroendocrine tumor cytologic genotype diversity to guide personalized medicine using a custom gastroenteropancreatic next-generation sequencing panel. Gleeson FC, etal., Oncotarget. 2017 Jun 28;8(55):93464-93475. doi: 10.18632/oncotarget.18750. eCollection 2017 Nov 7.
7. Daxx inhibits muscle differentiation by repressing E2A-mediated transcription. Gupta A, etal., J Cell Biochem. 2009 Jun 1;107(3):438-47. doi: 10.1002/jcb.22140.
8. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Jiao Y, etal., Science. 2011 Mar 4;331(6021):1199-203. doi: 10.1126/science.1200609. Epub 2011 Jan 20.
9. Subcellular localization of Daxx determines its opposing functions in ischemic cell death. Jung YS, etal., FEBS Lett. 2007 Mar 6;581(5):843-52. Epub 2007 Feb 2.
10. Telomere length abnormalities and telomerase RNA component expression in gastroenteropancreatic neuroendocrine tumors. Kim HS, etal., Anticancer Res. 2015 Jun;35(6):3501-10.
11. Discrimination of low- and high-grade appendiceal mucinous neoplasms by targeted sequencing of cancer-related variants. LaFramboise WA, etal., Mod Pathol. 2019 Jul;32(8):1197-1209. doi: 10.1038/s41379-019-0256-2. Epub 2019 Apr 8.
12. Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. Lalioti VS, etal., J Cell Physiol. 2009 Feb;218(2):416-26. doi: 10.1002/jcp.21614.
13. Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis. Lin CW, etal., Nat Commun. 2016 Dec 22;7:13867. doi: 10.1038/ncomms13867.
14. Daxx and TCF4 interaction links to oral squamous cell carcinoma growth by promoting cell cycle progression via induction of cyclin D1 expression. Lin GJ, etal., Clin Oral Investig. 2016 Apr;20(3):533-40. doi: 10.1007/s00784-015-1536-y. Epub 2015 Jul 24.
15. [Expression of Daxx in children with acute leukemia]. Liu J, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):33-6.
16. Death Domain-Associated Protein Promotes Colon Cancer Metastasis through Direct Interaction with ZEB1. Liu Y, etal., J Cancer. 2020 Jan 1;11(3):750-758. doi: 10.7150/jca.34233. eCollection 2020.
17. Induction of proapoptotic Daxx following ischemic acute kidney injury. Ma Q and Devarajan P, Kidney Int. 2008 Aug;74(3):310-8. doi: 10.1038/ki.2008.192. Epub 2008 May 14.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor. Mizuta H and Kuroda Y, Cell Biol Int 2004;28(8-9):609-14.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Blocking Daxx trafficking attenuates neuronal cell death following ischemia/reperfusion in rat hippocampus CA1 region. Niu YL, etal., Arch Biochem Biophys. 2011 Nov;515(1-2):89-98. doi: 10.1016/j.abb.2011.07.016. Epub 2011 Aug 6.
22. Death domain-associated protein DAXX promotes ovarian cancer development and chemoresistance. Pan WW, etal., J Biol Chem. 2013 May 10;288(19):13620-30. doi: 10.1074/jbc.M112.446369. Epub 2013 Mar 28.
23. Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases. Pea A, etal., Ann Surg. 2020 Mar;271(3):566-573. doi: 10.1097/SLA.0000000000003022.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. A role for transforming growth factor-beta apoptotic signaling pathway in liver injury induced by ingestion of water contaminated with high levels of Cr(VI). Rafael AI, etal., Toxicol Appl Pharmacol. 2007 Oct 15;224(2):163-73. Epub 2007 Jul 18.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. SUMO modified proteins localize to the XY body of pachytene spermatocytes. Rogers RS, etal., Chromosoma. 2004 Nov;113(5):233-43. Epub 2004 Sep 3.
31. Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. Schreiner S, etal., J Virol. 2011 Sep;85(17):8752-65. doi: 10.1128/JVI.00440-11. Epub 2011 Jun 22.
32. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
33. Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence. Tsourlakis MC, etal., Hum Pathol. 2013 Sep;44(9):1789-96. doi: 10.1016/j.humpath.2013.01.022. Epub 2013 May 2.
34. Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. Tzeng SL, etal., J Biol Chem. 2006 Jun 2;281(22):15405-11. Epub 2006 Mar 28.
35. Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. Walter L and Gunther E, Immunogenetics 2000 Aug;51(10):829-37.
36. DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer. Wu C, etal., Br J Cancer. 2020 May;122(10):1477-1485. doi: 10.1038/s41416-020-0800-3. Epub 2020 Mar 23.
37. Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats. Xiao B, etal., Neurotox Res. 2007 Oct;12(3):155-62.
38. Prognostic significance of Daxx NCR (Nuclear/Cytoplasmic Ratio) in gastric cancer. Xu JF, etal., Cancer Med. 2017 Sep;6(9):2063-2075. doi: 10.1002/cam4.1144. Epub 2017 Aug 15.
39. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
40. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. Yun HJ, etal., EMBO J. 2011 May 13;30(12):2465-76. doi: 10.1038/emboj.2011.152.
41. DAXX Mutation Status of Embolization-Treated Neuroendocrine Tumors Predicts Shorter Time to Hepatic Progression. Ziv E, etal., J Vasc Interv Radiol. 2018 Nov;29(11):1519-1526. doi: 10.1016/j.jvir.2018.05.023. Epub 2018 Oct 19.
42. Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma. Zizzi A, etal., Diagn Pathol. 2013 Jul 2;8:111. doi: 10.1186/1746-1596-8-111.
43. Daxx inhibits stress-induced apoptosis in cardiac myocytes. Zobalova R, etal., Redox Rep. 2008;13(6):263-70. doi: 10.1179/135100008X308975.
Additional References at PubMed
PMID:10444590   PMID:10504293   PMID:10669754   PMID:10684855   PMID:10698492   PMID:11799127   PMID:11971979   PMID:12140263   PMID:12477932   PMID:12529400   PMID:12917339   PMID:15016915  
PMID:15060004   PMID:15252119   PMID:15572661   PMID:15878163   PMID:15983381   PMID:16845383   PMID:17081986   PMID:18200667   PMID:18566590   PMID:19198660   PMID:20211137   PMID:20504901  
PMID:20651253   PMID:21134643   PMID:22500635   PMID:23444137   PMID:26812044   PMID:27733539   PMID:28501693  


Genomics

Comparative Map Data
Daxx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,971,973 - 4,978,062 (-)NCBIGRCr8
mRatBN7.2204,970,090 - 4,976,145 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,970,092 - 4,975,843 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,693,494 - 5,699,246 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,055,239 - 5,060,991 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,535,985 - 5,541,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,480,103 - 5,485,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,480,103 - 5,485,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,538,715 - 7,544,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,121,854 - 5,127,601 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,122,244 - 5,126,875 (-)NCBI
Celera206,554,093 - 6,559,840 (-)NCBICelera
Cytogenetic Map20p12NCBI
DAXX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,318,558 - 33,322,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,318,558 - 33,323,016 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,286,335 - 33,290,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,394,367 - 33,398,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,394,380 - 33,398,682NCBI
Celera634,840,701 - 34,845,159 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,027,906 - 33,032,806 (-)NCBIHuRef
CHM1_1633,288,251 - 33,292,710 (-)NCBICHM1_1
T2T-CHM13v2.0633,139,920 - 33,144,321 (-)NCBIT2T-CHM13v2.0
Daxx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,128,379 - 34,134,564 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,128,388 - 34,134,564 (+)EnsemblGRCm39 Ensembl
GRCm381733,909,404 - 33,915,590 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,909,414 - 33,915,590 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,046,443 - 34,052,534 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,520,055 - 33,526,038 (+)NCBIMGSCv36mm8
Celera1736,662,421 - 36,668,513 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Daxx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,869,572 - 1,873,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,869,692 - 1,874,041 (-)NCBIChiLan1.0ChiLan1.0
DAXX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,796,450 - 47,801,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,668,130 - 43,673,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,890,846 - 32,895,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,004,362 - 34,008,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,004,543 - 34,008,717 (-)Ensemblpanpan1.1panPan2
DAXX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,755,960 - 2,760,687 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,755,960 - 2,761,340 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,836,834 - 2,841,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,087,394 - 3,092,130 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,087,394 - 3,091,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,754,580 - 2,759,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,835,893 - 2,840,633 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,910,802 - 2,915,532 (-)NCBIUU_Cfam_GSD_1.0
Daxx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,409,877 - 38,414,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,546,036 - 25,550,392 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,546,091 - 25,550,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAXX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,676,856 - 29,681,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,676,854 - 29,681,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,180,626 - 34,184,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAXX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,754,227 - 38,758,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,754,280 - 38,759,071 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,153,334 - 33,157,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Daxx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,505,386 - 23,509,241 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,504,465 - 23,509,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Daxx
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000000559
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2047270785024580Rat

Markers in Region
AA926063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,976,497 - 4,976,712 (+)MAPPERmRatBN7.2
Rnor_6.0205,486,510 - 5,486,724NCBIRnor6.0
Rnor_5.0207,545,122 - 7,545,336UniSTSRnor5.0
RGSC_v3.4205,128,261 - 5,128,475UniSTSRGSC3.4
Celera206,560,500 - 6,560,714UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 38 23 19 23 1 68 30 41 11
Low 16 19 18 18 8 10 6 5 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB064671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000559   ⟹   ENSRNOP00000000559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,970,092 - 4,975,834 (-)Ensembl
Rnor_6.0 Ensembl205,480,103 - 5,485,850 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092272   ⟹   ENSRNOP00000075785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,483,985 - 5,485,837 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,480,104 - 5,481,955 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092597   ⟹   ENSRNOP00000075764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,970,778 - 4,975,843 (-)Ensembl
Rnor_6.0 Ensembl205,480,112 - 5,485,926 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,485,051 - 5,485,829 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,483,663 - 5,484,427 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119385   ⟹   ENSRNOP00000096625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,970,195 - 4,975,773 (-)Ensembl
RefSeq Acc Id: NM_080891   ⟹   NP_543167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,720 (-)NCBI
mRatBN7.2204,970,090 - 4,975,838 (-)NCBI
Rnor_6.0205,480,103 - 5,485,850 (-)NCBI
Rnor_5.0207,538,715 - 7,544,538 (-)NCBI
RGSC_v3.4205,121,854 - 5,127,601 (-)RGD
Celera206,554,093 - 6,559,840 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256106   ⟹   XP_006256168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,752 (-)NCBI
mRatBN7.2204,970,090 - 4,975,864 (-)NCBI
Rnor_6.0205,480,333 - 5,485,869 (-)NCBI
Rnor_5.0207,538,715 - 7,544,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256107   ⟹   XP_006256169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,733 (-)NCBI
mRatBN7.2204,970,090 - 4,975,852 (-)NCBI
Rnor_6.0205,480,333 - 5,485,869 (-)NCBI
Rnor_5.0207,538,715 - 7,544,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256108   ⟹   XP_006256170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,978,062 (-)NCBI
mRatBN7.2204,970,090 - 4,976,145 (-)NCBI
Rnor_6.0205,480,333 - 5,485,962 (-)NCBI
Rnor_5.0207,538,715 - 7,544,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256110   ⟹   XP_006256172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,978,054 (-)NCBI
mRatBN7.2204,970,090 - 4,976,140 (-)NCBI
Rnor_6.0205,480,103 - 5,485,962 (-)NCBI
Rnor_5.0207,538,715 - 7,544,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098392   ⟹   XP_038954320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,793 (-)NCBI
mRatBN7.2204,970,090 - 4,975,866 (-)NCBI
RefSeq Acc Id: XM_063278939   ⟹   XP_063135009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,796 (-)NCBI
RefSeq Acc Id: XM_063278940   ⟹   XP_063135010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,732 (-)NCBI
RefSeq Acc Id: XM_063278941   ⟹   XP_063135011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,753 (-)NCBI
RefSeq Acc Id: XM_063278942   ⟹   XP_063135012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,971,973 - 4,977,744 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_543167   ⟸   NM_080891
- UniProtKB: Q8VIB2 (UniProtKB/Swiss-Prot),   Q6MGC8 (UniProtKB/TrEMBL),   A6JJI8 (UniProtKB/TrEMBL),   A1A5M7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256172   ⟸   XM_006256110
- Peptide Label: isoform X2
- UniProtKB: Q8VIB2 (UniProtKB/Swiss-Prot),   Q6MGC8 (UniProtKB/TrEMBL),   A6JJI8 (UniProtKB/TrEMBL),   A1A5M7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256170   ⟸   XM_006256108
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP1 (UniProtKB/TrEMBL),   A0A0U1RRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256168   ⟸   XM_006256106
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP1 (UniProtKB/TrEMBL),   A0A0U1RRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256169   ⟸   XM_006256107
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP1 (UniProtKB/TrEMBL),   A0A0U1RRP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075785   ⟸   ENSRNOT00000092272
RefSeq Acc Id: ENSRNOP00000075764   ⟸   ENSRNOT00000092597
RefSeq Acc Id: ENSRNOP00000000559   ⟸   ENSRNOT00000000559
RefSeq Acc Id: XP_038954320   ⟸   XM_039098392
- Peptide Label: isoform X2
- UniProtKB: Q8VIB2 (UniProtKB/Swiss-Prot),   Q6MGC8 (UniProtKB/TrEMBL),   A6JJI8 (UniProtKB/TrEMBL),   A1A5M7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096625   ⟸   ENSRNOT00000119385
RefSeq Acc Id: XP_063135009   ⟸   XM_063278939
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135011   ⟸   XM_063278941
- Peptide Label: isoform X2
- UniProtKB: A1A5M7 (UniProtKB/TrEMBL),   A6JJI8 (UniProtKB/TrEMBL),   Q6MGC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135012   ⟸   XM_063278942
- Peptide Label: isoform X2
- UniProtKB: A1A5M7 (UniProtKB/TrEMBL),   A6JJI8 (UniProtKB/TrEMBL),   Q6MGC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135010   ⟸   XM_063278940
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP1 (UniProtKB/TrEMBL)
Protein Domains
Daxx histone-binding   Daxx N-terminal Rassf1C-interacting

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIB2-F1-model_v2 AlphaFold Q8VIB2 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701419
Promoter ID:EPDNEW_R11940
Type:multiple initiation site
Name:Daxx_1
Description:death-domain associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,485,833 - 5,485,893EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621227 AgrOrtholog
BioCyc Gene G2FUF-4513 BioCyc
Ensembl Genes ENSRNOG00000000477 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000559.5 UniProtKB/TrEMBL
  ENSRNOT00000092597.2 UniProtKB/TrEMBL
  ENSRNOT00000119385.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.810 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.2170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366304 IMAGE-MGC_LOAD
InterPro DAXX_histone_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAXX_histone_binding_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Daxx_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Daxx_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140926 UniProtKB/TrEMBL
MGC_CLONE MGC:156601 IMAGE-MGC_LOAD
NCBI Gene 140926 ENTREZGENE
PANTHER DEATH DOMAIN-ASSOCIATED PROTEIN 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Daxx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAXX_hist_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Daxx PhenoGen
RatGTEx ENSRNOG00000000477 RatGTEx
UniProt A0A0U1RRP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLP1 ENTREZGENE, UniProtKB/TrEMBL
  A1A5M7 ENTREZGENE, UniProtKB/TrEMBL
  A6JJI8 ENTREZGENE
  DAXX_RAT UniProtKB/Swiss-Prot
  Q6MGC8 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIB2 ENTREZGENE
UniProt Secondary A6JJI8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Daxx  death-domain associated protein  Daxx  Fas death domain-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Daxx  Fas death domain-associated protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Daxx  Fas death domain-associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mapping found within the rat major histocompatibility RT1 complex 1300431