RGD Reference Report - [Expression of Daxx in children with acute leukemia]. - Rat Genome Database

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[Expression of Daxx in children with acute leukemia].

Authors: Liu, Jing  Zhang, Liu-Qing  Hu, Qun  Lin, Han-Hua  Liu, Ai-Guo  Tao, Hong-Fang  Song, Yan-Qing  Zhang, Xiao-Ling 
Citation: Liu J, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):33-6.
RGD ID: 9587840
Pubmed: PMID:17306074   (View Abstract at PubMed)


OBJECTIVE: To investigate Daxx expression and its clinical significance in children with acute leukemia.
METHODS: The expression of Daxx protein was detected by immunohistochemical assay in 50 children with newly diagnosed acute leukemia (34 cases of acute lymphocytic leukemia and 16 cases of acute non-lymphocytic leukemia). Twenty children with normal bone marrow were used as the control group.
RESULTS: Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05). The children with acute non-lymphocytic leukemia had significantly higher Daxx expression levels (62.5%) than those with acute lymphocytic leukemia (26.5%; P < 0.05) as well as the control group (P < 0.05). There were no significant differences in the Daxx expression between acute lymphocytic leukemia children and the control group. Daxx protein was expressed in 55.6% of high risk group of acute lymphocytic leukemia but it was not expressed in standard risk group of acute lymphocytic leukemia (P < 0.05).
CONCLUSIONS: Daxx expression is abnormal in children with acute leukemia and associated with some clinical features of acute leukemia, suggesting that it may play an important role in the genesis and development of acute leukemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
leukemia  IEP 9587840protein:increased expression:bone marrow:RGD 
leukemia  ISODAXX (Homo sapiens)9587840; 9587840protein:increased expression:bone marrow:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Daxx  (death-domain associated protein)

Genes (Mus musculus)
Daxx  (Fas death domain-associated protein)

Genes (Homo sapiens)
DAXX  (death domain associated protein)


Additional Information