Ren (renin) - Rat Genome Database

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Gene: Ren (renin) Rattus norvegicus
Analyze
Symbol: Ren
Name: renin
RGD ID: 3554
Description: Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cGMP; and response to lipopolysaccharide. Located in extracellular space. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction and alcohol associated liver disease; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease 4; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin); PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin 1; renin 1 structural
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Renem1Mcwi
Genetic Models: SS-Renem1Mcwi ; SS-Renem1Mcwi+/- ; SS-Renem1Mcwi-/-
Is Marker For: Strains:   SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi ; SS.BN-(D13Rat20-D13Rat127)/Mcwi
QTLs:   Bp24   Bp5  
Candidate Gene For: Bp80 Bp328 Bp395
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81347,348,312 - 47,359,539 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1347,348,143 - 47,359,543 (+)EnsemblGRCr8
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)Ensemblrn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autosomal dominant tubulointerstitial kidney disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (ISO)
chronic fatigue syndrome  (ISO)
Chronic Intermittent Hypoxia  (IEP)
colitis  (ISO)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (IEP,ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
hand, foot and mouth disease  (ISO)
Hemorrhage  (ISO)
hepatoblastoma  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (IDA,IEP,ISO)
Hyponatremia  (IEP)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (IEP,ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
periodontal disease  (ISO)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (IEP)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Retina Reperfusion Injury  (IMP)
Tonne-Kalscheuer syndrome  (ISO)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-Phenylaminoadenosine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol  (ISO)
6alpha-methylprednisolone  (EXP)
acebutolol  (EXP,ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adenosine  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
aliskiren  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-methyl-L-dopa  (EXP)
alprenolol  (ISO)
aluminium phosphide  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
atenolol  (EXP,ISO)
benazepril  (EXP,ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
bumetanide  (ISO)
bunitrolol  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin A  (EXP)
candesartan  (EXP,ISO)
carvedilol  (EXP,ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlordecone  (ISO)
chlorisondamine  (EXP)
chlorthalidone  (ISO)
choline  (ISO)
cilazapril monohydrate  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cyanamide  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
Deoxycorticosterone acetate  (EXP)
desflurane  (ISO)
dexamethasone  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydralazine  (ISO)
diltiazem  (ISO)
dioxygen  (EXP)
disodium cromoglycate  (EXP)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP)
endralazine  (EXP)
esmolol  (ISO)
ethanol  (EXP)
fenoterol  (ISO)
fentanyl  (ISO)
folic acid  (ISO)
furosemide  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
Guanfacine  (ISO)
halothane  (ISO)
hydralazine  (EXP,ISO)
hydrochlorothiazide  (EXP,ISO)
ICI 118551  (ISO)
indapamide  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
iooxitalamic acid  (EXP)
irbesartan  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
Isradipine  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
ketoprofen  (ISO)
L-methionine  (ISO)
labetalol  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP,ISO)
losartan  (EXP,ISO)
magnesium sulfate  (ISO)
meclofenamic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
metoprolol  (EXP,ISO)
milrinone  (ISO)
minoxidil  (EXP,ISO)
ML-7  (EXP)
Moniliformin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nebivolol  (EXP)
nicardipine  (ISO)
nifedipine  (ISO)
Nilvadipine  (EXP)
nitrendipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitroglycerin  (ISO)
nitroprusside  (EXP,ISO)
O-methyleugenol  (ISO)
organophosphorus compound  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
pentobarbital  (EXP)
perindopril  (EXP,ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pindolol  (ISO)
piperidines  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
practolol  (EXP)
prazosin  (EXP,ISO)
probenecid  (ISO)
propofol  (ISO)
propranolol  (EXP,ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
purines  (EXP)
quercetin  (EXP)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
ramipril  (EXP,ISO)
ranitidine  (ISO)
reboxetine  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
ritodrine  (ISO)
sildenafil citrate  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium fluoride  (EXP)
soyasaponin I  (ISO)
Soyasaponin II  (ISO)
spirapril  (EXP)
spironolactone  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
telmisartan  (EXP)
terbutaline  (ISO)
Testosterone propionate  (EXP)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
tienilic acid  (ISO)
titanium dioxide  (EXP)
torasemide  (EXP)
trandolapril  (EXP,ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
yohimbine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical part of cell  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Strong association of a renin intronic dimorphism with essential hypertension. Ahmad U, etal., Hypertens Res. 2005 Apr;28(4):339-44.
2. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. Alderman MH, etal., N Engl J Med. 1991 Apr 18;324(16):1098-104.
3. Maternal and fetal plasma renin and dopamine-beta-hydroxylase activities in toxemic pregnancy. Annat G, etal., Obstet Gynecol. 1978 Aug;52(2):219-24.
4. [Hypertension-induced fibrosis: A balance story.] Azibani F, etal., Ann Cardiol Angeiol (Paris). 2012 May 25.
5. Subcellular localization of renin and kallikrein in rat kidney. Baggio B, etal., Ital J Biochem. 1975 May-Aug;24(3-4):199-206.
6. Molecular cloning of rat renin cDNA and its gene. Burnham CE, etal., Proc Natl Acad Sci U S A 1987 Aug;84(16):5605-9.
7. Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30.
8. Adipogenic differentiation of adipose tissue-derived human mesenchymal stem cells: effect of gastric bypass surgery. Chen JG, etal., Surg Endosc. 2012 May 31.
9. Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons. Chen SD, etal., Neurochem Int. 2012 May 17;61(3):369-377.
10. Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock. Chung KS, etal., Korean J Crit Care Med. 2017 May;32(2):142-153. doi: 10.4266/kjccm.2017.00094. Epub 2017 May 31.
11. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Clausmeyer S, etal., Circ Res 1999 Feb 19;84(3):337-44.
12. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
13. Chronic depression symptoms desensitize renin activity to protect against volume-loading hypertension in Blacks: The SABPA study. De Vos AC, etal., Physiol Behav. 2018 Oct 1;194:474-480. doi: 10.1016/j.physbeh.2018.06.038. Epub 2018 Jun 28.
14. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
15. Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang. Feng Q, etal., Biosci Rep. 2018 Jun 27;38(3). pii: BSR20171522. doi: 10.1042/BSR20171522. Print 2018 Jun 29.
16. Structure of the rat renin gene. Fukamizu A, etal., J Mol Biol 1988 May 20;201(2):443-50.
17. Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells. Gambaryan S, etal., Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9003-8.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients. Gleeson PJ, etal., Crit Care Med. 2019 Feb;47(2):152-158. doi: 10.1097/CCM.0000000000003544.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats. Gonzalez AA, etal., Hypertension. 2011 Apr;57(4):859-64. Epub 2011 Feb 14.
22. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Gribouval O, etal., Nat Genet. 2005 Sep;37(9):964-8. Epub 2005 Aug 14.
23. TASK-3 channel deletion in mice recapitulates low-renin essential hypertension. Guagliardo NA, etal., Hypertension. 2012 May;59(5):999-1005. Epub 2012 Apr 9.
24. Alteration of embryonic AT(2)-R and inflammatory cytokines gene expression induced by prenatal exposure to lipopolysaccharide affects renal development. Hao XQ, etal., Exp Toxicol Pathol. 2012 Feb 17.
25. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
26. Female-specific hypertension loci on rat chromosome 13. Hoffman MJ, etal., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1.
27. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Hsu CN, etal., Int J Mol Sci. 2018 Aug 20;19(8):2459. doi: 10.3390/ijms19082459.
28. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
29. Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower saponins in rats with metabolic hypertension by inhibiting the activation of the renin-angiotensin-aldosterone system through complement 3. Huang Q, etal., BMC Complement Med Ther. 2023 Jan 18;23(1):13. doi: 10.1186/s12906-022-03828-2.
30. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. Ichihara A, etal., J Clin Invest. 2004 Oct;114(8):1128-35.
31. Stress-induced activation of inactive renin. Molecular weight aspects. Jindra A Jr and Kvetnansky R, J Biol Chem. 1982 Jun 10;257(11):5997-9.
32. Angiotensin II feedback is a regulator of renocortical renin, COX-2, and nNOS expression. Kammerl MC, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jun;282(6):R1613-7.
33. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
34. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
35. [Study on changes in circulatory renin-angiotensin system in rats with endotoxemia]. Li JL, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Feb;18(2):92-5.
36. The increase in sympathetic nerve density in the atrium facilitates atrial fibrillation in patients with rheumatic heart disease. Li Y, etal., Int J Cardiol. 2011 Sep 10.
37. Temporal dissociation between sodium depletion and sodium appetite appearance: Involvement of inhibitory and stimulatory signals. Margatho LO, etal., Neuroscience. 2015 Jun 25;297:78-88. doi: 10.1016/j.neuroscience.2015.03.059. Epub 2015 Apr 1.
38. The renal vasodilatory effect of prostaglandins is ameliorated in isolated-perfused kidneys of endotoxemic mice. Meurer M, etal., Pflugers Arch. 2018 Nov;470(11):1691-1703. doi: 10.1007/s00424-018-2183-3. Epub 2018 Jul 19.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
41. Creation and characterization of a renin knockout rat. Moreno C, etal., Hypertension. 2011 Mar;57(3):614-9. doi: 10.1161/HYPERTENSIONAHA.110.163840. Epub 2011 Jan 17.
42. Isolation of renin granules from rat kidney cortex and evidence for an inactive form of renin (prorenin) in granules and plasma. Morris BJ and Johnston CI, Endocrinology. 1976 Jun;98(6):1466-74.
43. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. Renin/prorenin receptors. Nguyen G, Kidney Int. 2006 May;69(9):1503-6.
45. Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia. Nguyen LS, etal., Eur J Endocrinol. 2019 Nov;181(5):481-488. doi: 10.1530/EJE-19-0379.
46. Plasma Renin Concentration is Associated With Hemodynamic Deficiency and Adverse Renal Outcome in Septic Shock. Nguyen M, etal., Shock. 2019 Oct;52(4):e22-e30. doi: 10.1097/SHK.0000000000001285.
47. Chronic Stimulation of Renin Cells Leads to Vascular Pathology. Oka M, etal., Hypertension. 2017 Jul;70(1):119-128. doi: 10.1161/HYPERTENSIONAHA.117.09283. Epub 2017 May 22.
48. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. Okamoto LE, etal., Clin Sci (Lond). 2012 Feb;122(4):183-92. doi: 10.1042/CS20110200.
49. Aliskiren Attenuates the Inflammatory Response and Wound Healing Process in Diabetic Mice With Periodontal Disease. Oliveira SHP, etal., Front Pharmacol. 2019 Jul 4;10:708. doi: 10.3389/fphar.2019.00708. eCollection 2019.
50. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
51. Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats. Paliege A, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R694-700.
52. Ameliorative potential of aliskiren in experimental colitis in mice. Patel RB, etal., Eur J Pharmacol. 2014 Aug 15;737:70-6. doi: 10.1016/j.ejphar.2014.05.009. Epub 2014 May 21.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. GOA pipeline RGD automated data pipeline
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Coronary dilatation reserve in experimental hypertension and chronic heart failure: effects of blockade of the renin-angiotensin system. Richer C, etal., Clin Exp Pharmacol Physiol 2001 Dec;28(12):997-1001.
59. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Saris JJ, etal., Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1706-15.
60. Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Shah N, etal., J Hepatol. 2012 May;56(5):1047-53. Epub 2012 Jan 17.
61. Measurement of plasma active renin by solid phase radioimmunoassay using monoclonal antibodies. Shionoiri H, etal., Am J Med Sci. 1990 Sep;300(3):138-43. doi: 10.1097/00000441-199009000-00002.
62. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. St Lezin EM, etal., J Clin Invest. 1996 Jan 15;97(2):522-7.
63. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
64. Nucleotide sequence of rat renin cDNA. Tada M, etal., Nucleic Acids Res 1988 Apr 25;16(8):3576.
65. Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. Takatsu M, etal., J Hypertens. 2012 Jul 12.
66. Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury. Tenkumo K, etal., Exp Eye Res. 2014 May;122:110-8. doi: 10.1016/j.exer.2014.03.011. Epub 2014 Apr 5.
67. Structural analysis of 5'-flanking regions of rat, mouse and human renin genes reveals the presence of a transposable-like element in the two mouse genes. Tronik D, etal., Gene 1988 Sep 15;69(1):71-80.
68. Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure. Tsutamoto T, etal., Circ J. 2007 Jun;71(6):915-21. doi: 10.1253/circj.71.915.
69. Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass. Unger N, etal., Eur J Endocrinol. 2004 Apr;150(4):517-23. doi: 10.1530/eje.0.1500517.
70. Purification and characterization of two forms of rat plasma proangiotensin. Voigt J, etal., Eur J Biochem. 1982 Feb;122(1):183-91.
71. Continuous hemodiafiltration as a rescue therapy for patients with cardiopulmonary failure caused by enterovirus-71: a retrospective observational study in a PICU. Wang C, etal., BMC Infect Dis. 2019 Oct 21;19(1):866. doi: 10.1186/s12879-019-4519-9.
72. Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension. Warner GM, etal., Am J Physiol Renal Physiol. 2012 Jun;302(11):F1455-64. Epub 2012 Feb 29.
73. Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat. Wilkinson-Berka JL, etal., Mol Cell Endocrinol. 2002 Aug 30;194(1-2):201-9.
74. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Xiang W, etal., Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E125-32. Epub 2004 Sep 14.
75. Effect of pressor agents on blood pressure, plasma renin activity and plasma aldosterone concentration in essential hypertension. Yamamoto Y, Jpn Heart J. 1975 Jul;16(4):404-20. doi: 10.1536/ihj.16.404.
76. Elevation of plasma angiotensinogen in rats with experimentally induced nephrosis. Yayama K, etal., Nephron. 1993;63(1):89-93.
77. Assignment of 22 loci in the rat by somatic hybrid and linkage analysis. Yeung RS, etal., Mamm Genome 1993;4(10):585-8.
78. Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patient. Zhang L, etal., World J Gastroenterol. 2003 Jul;9(7):1584-8.
Additional References at PubMed
PMID:4289389   PMID:4322712   PMID:4330891   PMID:4360430   PMID:8490598   PMID:9933256   PMID:10318840   PMID:10617578   PMID:10807585   PMID:11145610   PMID:11702851   PMID:12045255  
PMID:12469222   PMID:12477932   PMID:12511427   PMID:12560203   PMID:14583438   PMID:15342908   PMID:15489334   PMID:15792957   PMID:15870381   PMID:17440033   PMID:17670863   PMID:18198281  
PMID:18202178   PMID:18413493   PMID:18426992   PMID:18509102   PMID:18653711   PMID:18671756   PMID:18782187   PMID:19050177   PMID:19139376   PMID:19171793   PMID:19261739   PMID:19293336  
PMID:19841286   PMID:19861503   PMID:20683339   PMID:20852041   PMID:21331057   PMID:21483231   PMID:21484732   PMID:21521778   PMID:21752621   PMID:21865264   PMID:22020141   PMID:23460292  
PMID:24119481   PMID:24204720   PMID:24436324   PMID:24473199   PMID:25394830   PMID:25707593   PMID:25766467   PMID:25767135   PMID:26256830   PMID:26322847   PMID:26660905   PMID:27090360  
PMID:27443990   PMID:27545826   PMID:28161727   PMID:28715805   PMID:29521603   PMID:30110572   PMID:30247805   PMID:34841988  


Genomics

Comparative Map Data
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81347,348,312 - 47,359,539 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1347,348,143 - 47,359,543 (+)EnsemblGRCr8
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)Ensemblrn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,154,815 - 204,190,324 (-)Ensemblhg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBIT2T-CHM13v2.0
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)Ensemblmm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBIMGSCv36mm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)Ensembl
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2145,210,086 - 45,221,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1145,175,312 - 45,186,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,045,917 - 184,057,431 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)EnsemblpanPan2panpan1.1
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567598,048 - 607,497 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ren
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ren
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1102,484,573 - 2,494,899 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ren
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003951
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
D13Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5UniSTS
Cytogenetic Map13q13UniSTS
D13Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,354,258 - 47,354,444 (+)Marker Load Pipeline
Rnor_5.01355,560,677 - 55,560,862NCBIRnor5.0
RGSC_v3.41346,269,934 - 46,270,118RGDRGSC3.4
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5UniSTS
RH 3.4 Map13173.5RGD
RH 2.0 Map13376.9RGD
Cytogenetic Map13q13UniSTS
D13Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,354,143 - 47,354,458 (+)Marker Load Pipeline
mRatBN7.21344,802,093 - 44,802,410 (-)MAPPERmRatBN7.2
Rnor_6.01350,507,805 - 50,508,121NCBIRnor6.0
Rnor_5.01355,560,664 - 55,560,980UniSTSRnor5.0
RGSC_v3.41346,269,816 - 46,270,132UniSTSRGSC3.4
RGSC_v3.41346,269,815 - 46,270,132RGDRGSC3.4
Celera1345,134,496 - 45,134,808UniSTS
RGSC_v3.11346,283,858 - 46,284,175RGD
RH 3.4 Map13182.9RGD
RH 3.4 Map13182.9UniSTS
SHRSP x BN Map1314.7498RGD
SHRSP x BN Map1314.7498UniSTS
Cytogenetic Map13q13UniSTS
RH94507  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,347,944 - 47,348,134 (+)Marker Load Pipeline
mRatBN7.21344,795,892 - 44,796,082 (-)MAPPERmRatBN7.2
Rnor_6.01350,514,131 - 50,514,320NCBIRnor6.0
Rnor_5.01355,566,990 - 55,567,179UniSTSRnor5.0
RGSC_v3.41346,262,569 - 46,262,758UniSTSRGSC3.4
Celera1345,128,755 - 45,128,944UniSTS
RH 3.4 Map13170.9UniSTS
Cytogenetic Map13q13UniSTS
RH138392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,807,241 - 44,807,417 (-)MAPPERmRatBN7.2
Rnor_6.01350,502,798 - 50,502,973NCBIRnor6.0
Rnor_5.01355,555,657 - 55,555,832UniSTSRnor5.0
RGSC_v3.41346,274,964 - 46,275,139UniSTSRGSC3.4
Celera1345,139,640 - 45,139,815UniSTS
RH 3.4 Map13181.6UniSTS
Cytogenetic Map13q13UniSTS


Related Rat Strains
The following Strains have been annotated to Ren
SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi     SS.BN-(D13Rat20-D13Rat127)/Mcwi    


Genetic Models
This gene Ren is modified in the following models/strains:
SS-Renem1Mcwi     SS-Renem1Mcwi+/-     SS-Renem1Mcwi-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 1 13 120 87 79 59 9 59 3 183 45 8 97 73 86 20 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000003951   ⟹   ENSRNOP00000003951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1347,348,143 - 47,359,535 (+)Ensembl
mRatBN7.2 Ensembl1344,796,091 - 44,807,487 (+)Ensembl
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076747   ⟹   ENSRNOP00000067953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,800,297 - 44,801,191 (+)Ensembl
Rnor_6.0 Ensembl1350,509,024 - 50,509,916 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097884   ⟹   ENSRNOP00000094943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1347,352,793 - 47,359,543 (+)Ensembl
mRatBN7.2 Ensembl1344,800,741 - 44,807,489 (+)Ensembl
RefSeq Acc Id: NM_012642   ⟹   NP_036774
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81347,348,312 - 47,359,539 (+)NCBI
mRatBN7.21344,796,260 - 44,807,491 (+)NCBI
Rnor_6.01350,502,724 - 50,513,953 (-)NCBI
Rnor_5.01355,555,583 - 55,566,812 (-)NCBI
RGSC_v3.41346,262,936 - 46,275,213 (+)RGD
Celera1345,129,122 - 45,139,889 (+)RGD
Sequence:
RefSeq Acc Id: NP_036774   ⟸   NM_012642
- Peptide Label: precursor
- UniProtKB: Q63497 (UniProtKB/Swiss-Prot),   P08424 (UniProtKB/Swiss-Prot),   A6IC75 (UniProtKB/TrEMBL),   A6IC76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003951   ⟸   ENSRNOT00000003951
Ensembl Acc Id: ENSRNOP00000067953   ⟸   ENSRNOT00000076747
Ensembl Acc Id: ENSRNOP00000094943   ⟸   ENSRNOT00000097884
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P08424-F1-model_v2 AlphaFold P08424 1-402 view protein structure  
Prorenin pdb 4amt P08424 27-402 view protein structure view video
Renin1 pdb 2x0b P08424 65-402 view protein structure view video

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3554 AgrOrtholog
BioCyc Gene G2FUF-18289 BioCyc
Ensembl Genes ENSRNOG00000002937 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003951 ENTREZGENE
  ENSRNOT00000003951.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126969 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
  Renin-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:24715 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93560 IMAGE-MGC_LOAD
NCBI Gene 24715 ENTREZGENE
PANTHER PTHR47966 UniProtKB/Swiss-Prot
  RENIN UniProtKB/Swiss-Prot
Pfam Asp UniProtKB/Swiss-Prot
PharmGKB REN RGD
PhenoGen Ren PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002937 RatGTEx
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
UniProt A0A8I6ANY3_RAT UniProtKB/TrEMBL
  A6IC75 ENTREZGENE, UniProtKB/TrEMBL
  A6IC76 ENTREZGENE, UniProtKB/TrEMBL
  P08424 ENTREZGENE
  Q63497 ENTREZGENE
  Q9JIE2_RAT UniProtKB/TrEMBL
  RENI_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63497 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Ren  renin  Ren1  renin 1 structural  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ren1  renin 1 structural  Ren1  renin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ren1  renin 1  Ren  Renin  Symbol and Name updated 629477 APPROVED
2002-06-10 Ren  Renin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease affects heart mass independent of blood pressure 1357231
gene_expression expressed in the juxtaglomerular apparatus 625761
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625761