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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases expression EXP 401793709RGD2,3,7,8-tetrachlorodibenzodioxine in pregnant dams increases expression of mRNA in kidney of male offspring 
Rendecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of REN mRNAPMID:32109520
Renincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of REN mRNAPMID:33387578
Rendecreases expressionISORen1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of REN1 mRNAPMID:12151645 PMID:12215675
Renmultiple interactionsISORen1 (Mus musculus)6480464CTDAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNA]PMID:12151645
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