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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:35457
Term: EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
Definition: An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1).
Chemical ID: MESH:D000806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDAngiotensin-Converting Enzyme Inhibitors results in increased activity of REN proteinPMID:231700 PMID:9140837 PMID:9201321
Renincreases expressionEXP 6480464CTDAngiotensin-Converting Enzyme Inhibitors results in increased expression of REN mRNA; Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN proteinPMID:1330361 PMID:9533614
Renmultiple interactionsEXP 6480464CTDAGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]PMID:3078272 PMID:6753910
Renincreases activityISOREN (Homo sapiens)6480464CTDAngiotensin-Converting Enzyme Inhibitors results in increased activity of REN proteinPMID:1647690 PMID:3071592 PMID:3152422 PMID:3326920 PMID:6280486 PMID:6290435 PMID:6324834
Renincreases expressionISOREN (Homo sapiens)6480464CTDAngiotensin-Converting Enzyme Inhibitors results in increased expression of REN proteinPMID:1668233 PMID:6168412 PMID:6388325
Renmultiple interactionsISOREN (Homo sapiens)6480464CTDAngiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and affects the activity of REN protein; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and results in increased activity of REN protein; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]PMID:3326920 PMID:6105291 PMID:7000102
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