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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:47426
Term: furosemide
Definition: A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Chemical ID: MESH:D005665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDFurosemide results in increased activity of REN proteinPMID:10604960 PMID:11135058
Renincreases expressionEXP 6480464CTDFurosemide results in increased expression of REN mRNA; Furosemide results in increased expression of REN proteinPMID:11135058 PMID:7954537 PMID:8418022
Renincreases secretionEXP 6480464CTDFurosemide results in increased secretion of REN proteinPMID:8418022
Renincreases activityISOREN (Homo sapiens)6480464CTDFurosemide results in increased activity of REN proteinPMID:11046100 PMID:1924052 PMID:599795
Renincreases expressionISORen1 (Mus musculus)6480464CTDFurosemide results in increased expression of REN mRNA; Furosemide results in increased expression of REN proteinPMID:15976003
Renincreases expressionISOREN (Homo sapiens)6480464CTDFurosemide results in increased expression of REN proteinPMID:3530574 PMID:4028619
Renmultiple interactionsISORen1 (Mus musculus)6480464CTDPTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]PMID:15976003
Renmultiple interactionsISOREN (Homo sapiens)6480464CTDFurosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]; Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]; Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]; Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]PMID:11095476 PMID:1924052 PMID:3530574 PMID:4028619
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