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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:8774
Term: ramipril
Definition: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Chemical ID: MESH:D017257
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases expressionEXP 6480464CTDRamipril results in increased expression of REN proteinPMID:9179393
Renmultiple interactionsEXP 6480464CTDRamipril inhibits the reaction [Doxorubicin results in increased expression of REN mRNA]; Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]PMID:11832429 PMID:36636964 PMID:9539862
Renincreases activityISOREN (Homo sapiens)6480464CTDRamipril results in increased activity of REN proteinPMID:1327051
Renincreases expressionISORen1 (Mus musculus)6480464CTDRamipril results in increased expression of REN mRNAPMID:14504926
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