GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ren | decreases activity | EXP | | 6480464 | CTD | Indomethacin results in decreased activity of REN protein | PMID:439781 | Ren | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of REN protein | PMID:27645307 | Ren | multiple interactions | EXP | | 6480464 | CTD | aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]; Indomethacin inhibits the reaction [Yohimbine results in increased expression of REN protein] | PMID:27645307 PMID:6323192 PMID:6753910 | Ren | decreases activity | ISO | REN (Homo sapiens) | 6480464 | CTD | Indomethacin results in decreased activity of REN protein | PMID:3884224 PMID:7035040 PMID:7049707 PMID:929154 | Ren | decreases expression | ISO | REN (Homo sapiens) | 6480464 | CTD | Indomethacin results in decreased expression of REN protein | PMID:119300 PMID:3530574 PMID:4028619 PMID:6758745 | Ren | multiple interactions | ISO | REN (Homo sapiens) | 6480464 | CTD | [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein; [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]; Indomethacin results in decreased expression of and results in decreased activity of REN protein | PMID:11078175 PMID:3530574 PMID:4028619 PMID:6756707 PMID:7049707 | |
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