LOSARTAN PHARMACODYNAMICS PATHWAY (PW:0001464)

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Description

Losartan is a selective and competitive non-peptide antagonist of angiotensin II receptor type 1 (Agtr1) used in the treatment of hypertension and heart failure. Angiotensin II (AngII) is one of several and probably the most potent peptide generated by the renin-angiotensin cascade. AngII signals through two receptor types to elicit distinct responses. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially h

Pathway Diagram:

Ariadne Genomics Inc. losartan ---- Lys199 losartan ---- Ser109 Asn295 ---- E3174 losartan Lys199 E3174 losartan pharmacokinetics pathway Asn295 Ser109 Asn295 ---- losartan E3174 ---- Lys199 E3174 ---- Ser109 Heart Failure Hypertension angiotensin II signaling pathway via AT1 receptor angiotensin II signaling pathway via AT1 receptor ---| Heart Failure Agt Agt ---| Agtr1a angiotensin II signaling pathway via AT1 receptor ---| Hypertension Agtr1a ---| angiotensin II signaling pathway via AT1 receptor Agtr1a
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Genes in Pathway:

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losartan pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:10402751
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:10402751
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:7364969
RGD:10402751
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the losartan pharmacodynamics pathway
Disease TermsGene Symbols
Abortion, SpontaneousAgtr1a
Acute Kidney InjuryAce
AdenocarcinomaAce
AIDS-Associated NephropathyAgtr1a
AlbuminuriaAce , Agt , Ren
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a , Ren
Alveolitis, Extrinsic AllergicAce
Alzheimer DiseaseAce , Agt , Agtr1a
AnaphylaxisAgt
AnemiaAce , Agt , Ren
Aneurysm, DissectingAgt
Angina, UnstableAce , Agt , Agtr1a
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
Anti-Glomerular Basement Membrane DiseaseAgt , Agtr1a
AnuriaAgt
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAce , Agt , Agtr1a
Aortic CalcificationAgt
Aortic CoarctationAce
Arrhythmias, CardiacAce , Agt , Agtr1a
Arteriovenous FistulaAce
Arthritis, ExperimentalAce
AsthmaAce , Agtr1a
AtherosclerosisAgt
Atrial FibrillationAce , Agt , Agtr1a , Ren
Autistic DisorderAce
AzotemiaRen
Bartter SyndromeRen
Behcet SyndromeAce
BerylliosisAce
Bipolar DisorderAce , Agt
BradycardiaAgt
Brain IschemiaAce
Breast NeoplasmsAce , Agt , Agtr1a
Bronchiolitis ObliteransAce
Carcinoma in SituAce
Carcinoma, HepatocellularAce
Carcinoma, Pancreatic DuctalAce , Agtr1a
Carcinoma, Renal CellAgtr1a
CardiomegalyAce , Agt , Agtr1a , Ren
CardiomyopathiesAgt
Cardiomyopathy, AlcoholicAce , Agt
Cardiomyopathy, DilatedAce , Agt , Agtr1a
Cardiomyopathy, HypertrophicAce , Agt
Cardiovascular AbnormalitiesAgt
Cardiovascular DiseasesAce , Agt
Carotid Artery DiseasesAce , Agt , Agtr1a
Carotid Artery InjuriesAgtr1a
CatalepsyAgt
Cerebral HemorrhageAce
Cerebral InfarctionAce
Cerebrovascular DisordersAgt , Agtr1a
Chemotherapy-Induced Febrile NeutropeniaAce
CholestasisAgt
Chronic Intermittent HypoxiaAce , Agt
Cognition DisordersAgt
Congenital Hepatic FibrosisAce
Corneal NeovascularizationAgt , Agtr1a
Coronary Artery DiseaseAce , Agt , Agtr1a
Coronary DiseaseAce , Agtr1a
Coronary RestenosisAce
Coronavirus InfectionsAce
CoughAce
Crohn DiseaseAgt
Death, SuddenAce , Agt
Diabetes Mellitus, ExperimentalAce , Agt , Ren
Diabetes Mellitus, Type 1Ace
Diabetes Mellitus, Type 2Ace , Agt
Diabetic CardiomyopathiesAce
Diabetic NephropathiesAce , Agt , Agtr1a , Ren
Diabetic RetinopathyAce , Agt , Agtr1a
Drug HypersensitivityAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsRen
Ductus Arteriosus, PatentAgtr1a
Endomyocardial FibrosisAce , Agt
EndotoxemiaAce
Epilepsy, Temporal LobeAgt
Erectile DysfunctionAgt
Fabry DiseaseAce
Familial Cerebral Cavernous MalformationAce
Fatigue Syndrome, ChronicRen
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Ren
FibrosisAgt , Agtr1a , Ren
Gallbladder NeoplasmsAce
Gaucher DiseaseAce
Genetic Predisposition to DiseaseAce
GlomerulonephritisAce , Agt
Glomerulonephritis, IGAAce , Agt , Agtr1a
GlomerulosclerosisAce , Agtr1a
Glomerulosclerosis, Focal SegmentalAgt , Agtr1a
Glycogen Storage Disease Type VAce
Heart DiseasesAgt
Heart FailureAce , Agt , Agtr1a , Ren
HemorrhageAgt , Ren
Hepatitis, AlcoholicAgt
Hernia, DiaphragmaticAgt
Hernias, Diaphragmatic, CongenitalAce
Huntington DiseaseAgtr1a
HydronephrosisAgt
HyperalgesiaAgt
HyperemiaAgt
HyperinsulinismAgt , Agtr1a
HyperoxiaAce
HypersensitivityAce , Agt
HypertensionAce , Agt , Agtr1a , Ren
Hypertension, EssentialAgt , Agtr1a
Hypertension, MalignantAgt , Ren
Hypertension, PortalRen
Hypertension, Pregnancy-InducedAce , Agt
Hypertension, PulmonaryAce , Agt , Agtr1a
Hypertension, RenalAgt , Agtr1a
Hypertension, RenovascularAce , Agtr1a , Ren
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce
HypertrophyAgt
Hypertrophy, Left VentricularAce , Agt , Agtr1a , Ren
Hypertrophy, Right VentricularAce
Hyperuricemic Nephropathy, Familial Juvenile 2Ren
Hyperuricemic Nephropathy, Familial Juvenile, 1Ren
HypokalemiaAgt
HypotensionAce , Agt , Ren
Infant, Premature, DiseasesAce
Infarction, Middle Cerebral ArteryAce , Agt
Infertility, MaleAce
InflammationAgt , Agtr1a
Inflammatory Bowel DiseasesAgt
Insulin ResistanceAce
Intracranial AneurysmAce
IschemiaRen
Ischemic Attack, TransientAgt
Juvenile GoutRen
Kidney DiseasesAce , Agt , Agtr1a , Ren
Kidney Failure, ChronicAce , Agt
Kidney Reperfusion InjuryAce
LeukemiaAce
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAce , Agt
LeukostasisAce
Liddle SyndromeRen
Liver CirrhosisAgt , Ren
Liver Cirrhosis, BiliaryAce , Agt , Ren
Liver Cirrhosis, ExperimentalAgt , Agtr1a
Lung DiseasesAce , Agtr1a
Lung NeoplasmsAce
Lupus Erythematosus, SystemicAce
Mammary Neoplasms, ExperimentalAgt , Agtr1a
Meconium Aspiration SyndromeAgt
Melanoma, Cutaneous MalignantAgt
Memory DisordersAce
Meningococcal InfectionsAce
Metabolic Syndrome XAgt , Agtr1a
Microvascular Complications of Diabetes, Susceptibility To, 1Ace
Microvascular Complications of Diabetes, Susceptibility To, 2Ace
Microvascular Complications of Diabetes, Susceptibility To, 3Ace
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4Ace
Microvascular Complications of Diabetes, Susceptibility To, 6Ace
Microvascular Complications of Diabetes, Susceptibility To, 7Ace
Mitral Valve ProlapseAce , Agt
Multiple MyelomaAce
Myocardial InfarctionAce , Agt , Agtr1a , Ren
Myocardial IschemiaAgt
Myocardial Reperfusion InjuryAgt , Agtr1a
MyocarditisAce
NecrosisAgt
NeointimaAgt
Neoplasm MetastasisAce , Agtr1a
NephritisAce , Agtr1a
NephrosisAce , Agt , Ren
Nephrosis, Puromycin AminonucleosideAce , Agt , Ren
Nephrotic SyndromeAce
Non-alcoholic Fatty Liver DiseaseAce
Nonarteritic Anterior Ischemic Optic NeuropathyAce
ObesityAce , Agt , Ren
Ocular HypotensionAce
OsteoporosisAce , Ren
OtosclerosisAgt
PainAce
Pancreatic NeoplasmsAce
Parkinson DiseaseAce , Agtr1a
Peptic Ulcer HemorrhageAgt
Peritoneal FibrosisAce
Pituitary NeoplasmsAgtr1a
Placental InsufficiencyAgtr1a
PneumoniaAce
Pneumonia, AspirationAce
Pneumonia, ViralAce
Polycystic Kidney, Autosomal RecessiveAce
PolycythemiaAce
Postoperative Cognitive DysfunctionAgtr1a
Pre-EclampsiaAce , Agt
Precancerous ConditionsAce
Prediabetic StateAgt
Prostatic NeoplasmsAce
ProteinuriaAce , Agt , Agtr1a , Ren
PsoriasisRen
Psychoses, Substance-InducedAce
Pulmonary Disease, Chronic ObstructiveAce
Pulmonary EdemaAgt
Pulmonary FibrosisAce , Agt , Agtr1a
Purpura, Schoenlein-HenochAce , Agt
PyelonephritisAce
Radiation Injuries, ExperimentalAgtr1a
Radiation nephropathyAce
Renal FibrosisAce
Renal InsufficiencyAce , Agt
Renal Insufficiency, ChronicAgtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a , Ren
Reperfusion InjuryAce , Agt
Respiratory Distress Syndrome, AdultAce
Respiratory Tract DiseasesAce
Retina Reperfusion InjuryRen
Retinal VasculitisAgt
Retinopathy of PrematurityAgt
Rhinitis, AllergicAce
SarcoidosisAce , Agtr1a
Sciatic NeuropathyAgt
Scleroderma, DiffuseAgt
Scleroderma, SystemicAce , Agt
Segmental GlomerulosclerosisAce
SeizuresAgt
Severe Acute Respiratory SyndromeAce
Sick Sinus SyndromeAgt
Sleep Apnea, ObstructiveAce
Smith-Magenis SyndromeAce
Spondylitis, AnkylosingAce
Staphylococcal InfectionsAce
Stomach NeoplasmsAce
Stomach UlcerAgt
StrokeAce , Agt
Substance Withdrawal SyndromeRen
ThrombosisAgt
Ureteral ObstructionAce , Agt
UveitisAce
Vascular RemodelingAgt
Vascular System InjuriesAce
Venous ThromboembolismAce
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Agtr1a
Vesico-Ureteral RefluxAgtr1a
Weight GainAce
Pathway Annotations Associated with Genes in the losartan pharmacodynamics pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a
angiotensin II signaling pathway via AT2 receptorAgt
angiotensin III signaling pathwayAgt , Agtr1a
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a
angiotensin III signaling pathway via AT2 receptorAgt
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphaq familyAgtr1a
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Ren
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
Trypanosoma cruzi infection pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the losartan pharmacodynamics pathway

References Associated with the losartan pharmacodynamics pathway:

Ontology Path Diagram:

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