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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:2904
Term: atenolol
Definition: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Chemical ID: MESH:D001262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rendecreases expressionEXP 6480464CTDAtenolol results in decreased expression of REN proteinPMID:9300315
Renmultiple interactionsEXP 6480464CTDAtenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]PMID:9300315
Rendecreases activityISOREN (Homo sapiens)6480464CTDAtenolol results in decreased activity of REN proteinPMID:18957387 PMID:3333524
Rendecreases expressionISOREN (Homo sapiens)6480464CTDAtenolol results in decreased expression of REN proteinPMID:14639093
Renmultiple interactionsISOREN (Homo sapiens)6480464CTD[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN proteinPMID:18957387 PMID:3142437
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