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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:5778
Term: hydrochlorothiazide
Definition: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:D006852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDHydrochlorothiazide results in increased activity of REN proteinPMID:11135058
Renincreases activityISOREN (Homo sapiens)6480464CTDHydrochlorothiazide results in increased activity of REN proteinPMID:1930859 PMID:2920503
Renincreases expressionISOREN (Homo sapiens)6480464CTDHydrochlorothiazide results in increased expression of REN proteinPMID:12569265
Renmultiple interactionsISOREN (Homo sapiens)6480464CTDLosartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]; Sodium affects the reaction [Hydrochlorothiazide results in increased activity of REN protein]PMID:12569265 PMID:1930859
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