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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3554
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ren
Name: renin
Acc ID: CHEBI:6942
Term: minoxidil
Definition: A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Chemical ID: MESH:D008914
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Renincreases activityEXP 6480464CTDMinoxidil results in increased activity of REN proteinPMID:145319
Renincreases expressionEXP 6480464CTDMinoxidil results in increased expression of REN proteinPMID:8238566
Renaffects expressionISOREN (Homo sapiens)6480464CTDMinoxidil affects the expression of REN proteinPMID:28811
Renmultiple interactionsISOREN (Homo sapiens)6480464CTDMinoxidil binds to and results in decreased activity of REN proteinPMID:790007
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