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 Gene Ontology

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Gene:
Pklr ( Rattus norvegicus )
pyruvate kinase, liver and RBC
Description:L-isozyme of pyruvate kinase; catalyzes the conversion of ATP and pyruvate to ADP and phosphoenolpyruvate in glycolysis
Synonyms:PK1; PKL; pyruvate kinase, liver and red blood cell; Pklg;  (details...)
ArrayIDs:1368651_at; GE1167852; 6127507; 6546907; 1387263_at; A_42_P606525; 5625043; 5934086; 6618991; 1369416_at; 6094212; 6092279; 6584796; 6148148; 1379447_at; GE19868; X05684_at; 6242407; 6071558; 6019511; 6290703; A_44_P278701; 6063948; 5841601; 6450684; 5703121;  (details...)
Gene Type:protein-coding
 
Additional Data
Markers: D2Arb15 D2Mgh28 D2Mit20 D2Wox19 D2Wox20 D2Wox21 D2Wox22
primer pair: 632338 635225
 
Homologs
Homo sapiens: PKLR     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pklr     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusPklrgenome assembly 3.12181164961 - 181173618
  Rat Celera Assembly2168486468 - 168494848
  RH 3.421154.4
  RGSC genome assembly v3.42181214853 - 181223512
  Cytogenetic2q34
Mus musculusPklrMouse genome assembly build 36.1388940064 - 88949555
  Cytogenetic33 F1
Homo sapiensPKLRhuman genome assembly1152072702 - 152084298
  Human genome assembly build 36.21153526254 - 153537835
  Cytogenetic1q21
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
Other Map Data:
Associated SSLP Map Locations
STSD2Arb15genome assembly 3.12181167751 - 181167950
  SHRSP x BN271.2798
  Rat cytogenetic map2
  FHH x ACI276.5599
  RGSC genome assembly v3.42181217645 - 181217844
STSD2Mgh28RH 2.0 2888.4
  genome assembly 3.12181167824 - 181167964
  SHRSP x BN271.5798
  RH 3.421162.7
  FHH x ACI276.5599
  RGSC genome assembly v3.42181217718 - 181217858
STSD2Mit20RH 2.0 2881.7
  genome assembly 3.14638593 - 638715
  RH 3.421154.4
  FHH x ACI276.6299
  RGSC genome assembly v3.44638592 - 638715
STSD2Wox19Rat cytogenetic map2
  RGSC genome assembly v3.42181212126 - 181212270
  genome assembly 3.12181162232 - 181162376
STSD2Wox20Rat cytogenetic map2
  RGSC genome assembly v3.42181213221 - 181213397
  genome assembly 3.12181163327 - 181163503
STSD2Wox21genome assembly 3.12181162225 - 181162396
  RH 3.421157.4
  Rat cytogenetic map2
  RGSC genome assembly v3.42181212119 - 181212290
STSD2Wox22Rat cytogenetic map2
  RGSC genome assembly v3.42181213206 - 181213358
  genome assembly 3.12181163312 - 181163464
 
 Annotation
Molecular Function
Gene Ontology
pyruvate kinase activity (details...)
Biological Process
Gene Ontology
response to other organism,  response to cAMP,  ATP biosynthetic process ...  (details...)
Cellular Component
Gene Ontology
soluble fraction,  cytosol (details...)
Disease
Ontology
Diabetes Mellitus, Experimental,  Hyperinsulinemia,  Insulin Resistance ...  (details...)
Expression
NoteReference
expressed in liver, kidney and small intestine633544
Pathway
Ontology
glycolysis/gluconeogenesis pathway,  carbon fixation pathway,  pyruvate metabolic pathway ...  (details...)
Transcript structure
NoteReference
three mRNA species of 2kb, 2.2kb and 3.2kb due to alternate sites of endonucleolytic cleavage in the 3' non-translated region633544
Domain
NoteReference
contains an N-terminal phosphorylation site633541
 
 External Links
Databases
DATABASEIDSOURCE
PROSITE:PYRUVATE_KINASEIPI
UNIPARC:UPI000002AD00IPI
UNIPARC:UPI000012E029IPI
KEGG Report:rno:24651ENTREZGENE
HomoloGene Group ID:37286ENTREZGENE
Germonline:3336
Pfam:PK_CIPI
Pfam:PKIPI
KEGG Pathway:01100ENTREZGENE
KEGG Pathway:04950ENTREZGENE
KEGG Pathway:00620ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:00010ENTREZGENE
KEGG Pathway:04930ENTREZGENE
KEGG Pathway:00230ENTREZGENE
InterPro:Pyrv_Knase_brl.IPI
InterPro:Pyr_Knase.IPI
InterPro:Pyrv/PenolPyrv_Kinase_cat.IPI
InterPro:Pyrv_Knase_a/b.IPI
InterPro:Pyrv_Knase_AS.IPI
InterPro:Pyrv_Knase_b-brl-like.IPI
InterPro:Pyrv_Knase_C-like.IPI
Ensembl Protein:ENSRNOP00000027700IPI
Ensembl Protein:ENSRNOP00000058886IPI
IPI:IPI00231683IPI
IPI:IPI00202549IPI
Gene3D-CATH:Pyrv/PenolPyrv_Kinase_catIPI
Gene3D-CATH:Pyrv_Knase_a/bIPI
Entrez Gene:PklrENTREZGENE
IMAGE_CLONE:IMAGE:7127842IMAGE-MGC_LOAD
MGC_CLONE:MGC:187302IMAGE-MGC_LOAD
Ensembl Genes:ENSRNOG00000020420IPI
UniProt:KPYR_RATIPI
UniProt:KPYR_RATIPI
UniProt:B1WBN9_RATIPI
RatMap:34290ENTREZGENE
Superfamily-SCOP:Pyruvate_kinaseIPI
Superfamily-SCOP:PK_B_barrel_likeIPI
Superfamily-SCOP:Pyrv/PenolPyrv_Kinase_catIPI
PANTHER:Pyruvate_kinaseIPI
TIGRFAMs:pyruv_kinIPI
PRINTS:PYRUVTKNASE.IPI
Sequences
Nucleotide:CH473976Get FASTASearch GEO Profiles
Nucleotide:BC161827Get FASTASearch GEO Profiles
Nucleotide:NM_012624Get FASTASearch GEO Profiles
Nucleotide:M11709Get FASTASearch GEO Profiles
Nucleotide:M17091Get FASTASearch GEO Profiles
Nucleotide:X05684Get FASTASearch GEO Profiles
(View all 6 Nucleotide Accessions)
Protein:NP_036756Get FASTA
Protein:EDM00668Get FASTA
Protein:AAA41883Get FASTA
Protein:CAA29169Get FASTA
Protein:AAI61827Get FASTA
Protein:AAA41880Get FASTA
Protein:P12928Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene:48821
 
 References
Curated References
29 references in RGD related to Pklr
Other References
30 other references at PubMed related to Pklr
 
 Database Information
RGD ID3336
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
09-SEP-08: Pklr pyruvate kinase, liver and RBC Pklr pyruvate kinase, liver and red blood cell APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
17-NOV-05: Pklr pyruvate kinase, liver and red blood cell APPROVED Name updated 1299863
10-JUN-02: Pklr pyruvate kinase, liver and RBC APPROVED Symbol and Name status set to approved 70586

       

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