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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pklr
Name: pyruvate kinase L/R
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pklrdecreases expressionEXP 6480464CTDPhenobarbital results in decreased expression of PKLR mRNAPMID:19162173
Pklraffects expressionISOPklr (Mus musculus)6480464CTDPhenobarbital affects the expression of PKLR mRNAPMID:23091169
Pklrincreases expressionISOPklr (Mus musculus)6480464CTDPhenobarbital results in increased expression of PKLR mRNAPMID:19270015 PMID:19482888
Pklrmultiple interactionsISOPklr (Mus musculus)6480464CTDNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PKLR mRNA]PMID:19482888
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