PKLR (pyruvate kinase L/R) - Rat Genome Database

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Gene: PKLR (pyruvate kinase L/R) Sus scrofa
Analyze
Symbol: PKLR
Name: pyruvate kinase L/R
RGD ID: 13943488
Description: ENCODES a protein that exhibits monosaccharide binding (ortholog); pyruvate kinase activity (ortholog); INVOLVED IN cellular response to epinephrine stimulus (ortholog); cellular response to insulin stimulus (ortholog); glycolytic process (ortholog); PARTICIPATES IN Fanconi syndrome pathway; forkhead class A signaling pathway; glycogen storage disease type VII pathway; ASSOCIATED WITH Burns (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); congenital nonspherocytic hemolytic anemia (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); pyruvate kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyruvate kinase PKLR; pyruvate kinase, liver and RBC
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,537,019 - 94,546,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,536,978 - 94,546,561 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,324,615 - 103,327,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PKLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,537,019 - 94,546,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,536,978 - 94,546,561 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,324,615 - 103,327,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,289,293 - 155,308,654 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,289,293 - 155,301,438 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,259,084 - 155,271,229 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,526,254 - 153,537,835 (-)NCBINCBI36Build 36hg18NCBI36
Build 341152,072,702 - 152,084,298NCBI
Celera1128,332,260 - 128,344,368 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,621,396 - 126,633,527 (-)NCBIHuRef
CHM1_11156,654,499 - 156,666,666 (-)NCBICHM1_1
T2T-CHM13v2.01154,427,854 - 154,447,170 (-)NCBIT2T-CHM13v2.0
Pklr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,043,429 - 89,054,122 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,043,449 - 89,054,091 (+)EnsemblGRCm39 Ensembl
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBIMGSCv36mm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Pklr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,840,779 - 176,849,637 (+)NCBIGRCr8
mRatBN7.22174,543,008 - 174,551,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,543,039 - 174,551,870 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,689,431 - 181,697,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,711,798 - 179,720,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,311,737 - 174,320,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBICelera
RH 3.4 Map21154.4RGD
Cytogenetic Map2q34NCBI
Pklr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,739,152 - 1,749,632 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,742,432 - 1,749,632 (-)NCBIChiLan1.0ChiLan1.0
PKLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,540,674 - 94,554,495 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,272,005 - 94,285,754 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,634,111 - 130,646,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,239,565 - 134,250,957 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,239,565 - 134,251,351 (-)Ensemblpanpan1.1panPan2
PKLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,263,899 - 42,272,770 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,263,761 - 42,272,755 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,754,768 - 41,762,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,132,983 - 42,141,903 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,133,018 - 42,141,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,912,888 - 41,920,846 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,966,693 - 41,974,641 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,250,696 - 42,258,642 (+)NCBIUU_Cfam_GSD_1.0
Pklr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,740,581 - 25,749,528 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,767,109 - 4,779,916 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,770,977 - 4,799,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,540,228 - 8,547,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,540,763 - 8,545,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,877,122 - 7,888,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pklr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,264,928 - 2,272,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,261,850 - 2,272,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PKLR
188 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system respiratory system
High
Medium
Low 2
Below cutoff 7 2 1 5 8 3

Sequence


RefSeq Acc Id: ENSSSCT00000056990   ⟹   ENSSSCP00000036804
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl494,537,019 - 94,546,555 (+)Ensembl
RefSeq Acc Id: XM_021089721   ⟹   XP_020945380
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1494,536,978 - 94,546,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089722   ⟹   XP_020945381
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1494,536,999 - 94,546,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089723   ⟹   XP_020945382
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1494,537,007 - 94,546,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089724   ⟹   XP_020945383
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1494,537,096 - 94,546,561 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020945380   ⟸   XM_021089721
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VZC4 (UniProtKB/TrEMBL),   A0A287BAZ7 (UniProtKB/TrEMBL),   A0A286ZYV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945381   ⟸   XM_021089722
- Peptide Label: isoform X2
- UniProtKB: A0A480PP31 (UniProtKB/TrEMBL),   A0A8D0IQ14 (UniProtKB/TrEMBL),   A0A286ZYV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945382   ⟸   XM_021089723
- Peptide Label: isoform X3
- UniProtKB: A0A8D0XGL4 (UniProtKB/TrEMBL),   A0A286ZYV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945383   ⟸   XM_021089724
- Peptide Label: isoform X3
- UniProtKB: A0A8D0XGL4 (UniProtKB/TrEMBL),   A0A286ZYV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036804   ⟸   ENSSSCT00000056990

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026149 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005017563 UniProtKB/TrEMBL
  ENSSSCG00015069251 UniProtKB/TrEMBL
  ENSSSCG00025038520 UniProtKB/TrEMBL
  ENSSSCG00030056282 UniProtKB/TrEMBL
  ENSSSCG00035048414 UniProtKB/TrEMBL
  ENSSSCG00040029008 UniProtKB/TrEMBL
  ENSSSCG00045021421 UniProtKB/TrEMBL
  ENSSSCG00050031633 UniProtKB/TrEMBL
  ENSSSCG00055015284 UniProtKB/TrEMBL
  ENSSSCG00060041101 UniProtKB/TrEMBL
  ENSSSCG00065011075 UniProtKB/TrEMBL
  ENSSSCG00070027857 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056990 ENTREZGENE
  ENSSSCT00000056990.3 UniProtKB/TrEMBL
  ENSSSCT00005028297.1 UniProtKB/TrEMBL
  ENSSSCT00005028345.1 UniProtKB/TrEMBL
  ENSSSCT00015093023.1 UniProtKB/TrEMBL
  ENSSSCT00015093129.1 UniProtKB/TrEMBL
  ENSSSCT00015093199.1 UniProtKB/TrEMBL
  ENSSSCT00025052383.1 UniProtKB/TrEMBL
  ENSSSCT00030078451.1 UniProtKB/TrEMBL
  ENSSSCT00030078504.1 UniProtKB/TrEMBL
  ENSSSCT00030078554.1 UniProtKB/TrEMBL
  ENSSSCT00030078571.1 UniProtKB/TrEMBL
  ENSSSCT00030078616.1 UniProtKB/TrEMBL
  ENSSSCT00035064510.1 UniProtKB/TrEMBL
  ENSSSCT00040038995.1 UniProtKB/TrEMBL
  ENSSSCT00040039058.1 UniProtKB/TrEMBL
  ENSSSCT00045036669.1 UniProtKB/TrEMBL
  ENSSSCT00045036790.1 UniProtKB/TrEMBL
  ENSSSCT00050042542.1 UniProtKB/TrEMBL
  ENSSSCT00050042551.1 UniProtKB/TrEMBL
  ENSSSCT00055030220.1 UniProtKB/TrEMBL
  ENSSSCT00055030300.1 UniProtKB/TrEMBL
  ENSSSCT00060055705.1 UniProtKB/TrEMBL
  ENSSSCT00065014725.1 UniProtKB/TrEMBL
  ENSSSCT00070055889.1 UniProtKB/TrEMBL
  ENSSSCT00070055890.1 UniProtKB/TrEMBL
  ENSSSCT00070055892.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.33.10 UniProtKB/TrEMBL
  3.20.20.60 UniProtKB/TrEMBL
  3.40.1380.20 UniProtKB/TrEMBL
InterPro Pyr_Knase UniProtKB/TrEMBL
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/TrEMBL
  Pyrv_Kinase-like_dom_sf UniProtKB/TrEMBL
  Pyrv_Knase-like_insert_dom_sf UniProtKB/TrEMBL
  Pyrv_Knase_AS UniProtKB/TrEMBL
  Pyrv_Knase_brl UniProtKB/TrEMBL
  Pyrv_Knase_C UniProtKB/TrEMBL
  Pyrv_Knase_C_sf UniProtKB/TrEMBL
  Pyrv_Knase_insert_dom_sf UniProtKB/TrEMBL
NCBI Gene PKLR ENTREZGENE
PANTHER PTHR11817 UniProtKB/TrEMBL
  PYRUVATE KINASE PKLR UniProtKB/TrEMBL
Pfam PF00224 UniProtKB/TrEMBL
  PK_C UniProtKB/TrEMBL
PRINTS PYRUVTKNASE UniProtKB/TrEMBL
PROSITE PYRUVATE_KINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF50800 UniProtKB/TrEMBL
  SSF51621 UniProtKB/TrEMBL
  SSF52935 UniProtKB/TrEMBL
UniProt A0A286ZYV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BAZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A480PP31 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VZC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W0M5_PIG UniProtKB/TrEMBL
  A0A4X1W1T3_PIG UniProtKB/TrEMBL
  A0A8D0IQ14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XD59_PIG UniProtKB/TrEMBL
  A0A8D0XGJ0_PIG UniProtKB/TrEMBL
  A0A8D0XGL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XGM6_PIG UniProtKB/TrEMBL
  A0A8D1M305_PIG UniProtKB/TrEMBL
  Q9TTN8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91479 ENTREZGENE