PKLR (pyruvate kinase L/R) - Rat Genome Database

Name: PKLR
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: PKLR (pyruvate kinase L/R) Pan paniscus

Analyze

Symbol:

PKLR

Name:

pyruvate kinase L/R

RGD ID:

11766604

Description:

ENCODES a protein that exhibits monosaccharide binding (ortholog); pyruvate kinase activity (ortholog); INVOLVED IN cellular response to epinephrine stimulus (ortholog); cellular response to insulin stimulus (ortholog); glycolytic process (ortholog); PARTICIPATES IN Fanconi syndrome pathway; forkhead class A signaling pathway; glycogen storage disease type VII pathway; ASSOCIATED WITH Burns (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); congenital nonspherocytic hemolytic anemia (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); pyruvate kinase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyruvate kinase PKLR; pyruvate kinase, liver and RBC

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PKLR (pyruvate kinase L/R)	NCBI	Ortholog
Mus musculus (house mouse):	Pklr (pyruvate kinase liver and red blood cell)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pklr (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pklr (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PKLR (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pklr (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PKLR (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PKLR (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pklr (pyruvate kinase L/R)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	94,540,674 - 94,554,495 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	94,272,005 - 94,285,754 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	130,634,111 - 130,646,644 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	134,239,565 - 134,250,957 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	134,239,565 - 134,251,351 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Burns (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

congenital nonspherocytic hemolytic anemia (ISO)

Elevated Adenosine Triphosphate of Erythrocytes (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

gastrointestinal stromal tumor (ISO)

Gaucher's disease (ISO)

genetic disease (ISO)

hemolytic anemia (ISO)

hyperglycemia (ISO)

hyperinsulinism (ISO)

Hypertriglyceridemia (ISO)

immunodeficiency 42 (ISO)

Insulin Resistance (ISO)

malaria (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

MHC class II deficiency (ISO)

obesity (ISO)

parathyroid carcinoma (ISO)

pyruvate kinase deficiency of red cells (ISO)

Reperfusion Injury (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epinephrine stimulus (ISO)

cellular response to insulin stimulus (IEA,ISO)

glycolytic process (IEA,ISO)

pyruvate biosynthetic process (ISO)

response to ATP (ISO)

response to cAMP (ISO)

response to glucose (ISO)

response to hypoxia (ISO)

response to metal ion (ISO)

response to nutrient (ISO)

response to other organism (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

plasma membrane (ISO)

pyruvate kinase complex (ISO)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

magnesium ion binding (IEA)

metal ion binding (IEA)

monosaccharide binding (ISO)

potassium ion binding (IEA)

protein binding (ISO)

pyruvate kinase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fanconi syndrome pathway (ISO)

forkhead class A signaling pathway (ISO)

glycogen storage disease type VII pathway (ISO)

glycolysis pathway (ISO)

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PKLR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	94,540,674 - 94,554,495 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	94,272,005 - 94,285,754 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	130,634,111 - 130,646,644 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	134,239,565 - 134,250,957 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	134,239,565 - 134,251,351 (-)	Ensembl	panpan1.1		panPan2

PKLR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	155,289,293 - 155,308,654 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	155,289,293 - 155,301,438 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	155,259,084 - 155,271,229 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	153,526,254 - 153,537,835 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	152,072,702 - 152,084,298	NCBI
Celera	1	128,332,260 - 128,344,368 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	126,621,396 - 126,633,527 (-)	NCBI		HuRef
CHM1_1	1	156,654,499 - 156,666,666 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	154,427,854 - 154,447,170 (-)	NCBI		T2T-CHM13v2.0

Pklr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	89,043,429 - 89,054,122 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	89,043,449 - 89,054,091 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	89,136,122 - 89,146,815 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	89,136,142 - 89,146,784 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	88,940,064 - 88,950,516 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	89,222,069 - 89,231,560 (+)	NCBI		MGSCv36	mm8
Celera	3	89,168,271 - 89,180,284 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	39.01	NCBI

Pklr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,840,779 - 176,849,637 (+)	NCBI		GRCr8
mRatBN7.2	2	174,543,008 - 174,551,863 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	174,543,039 - 174,551,870 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	181,689,431 - 181,697,810 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	179,711,798 - 179,720,184 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	174,311,737 - 174,320,129 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	188,449,158 - 188,458,034 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	188,449,210 - 188,459,592 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	207,865,529 - 207,874,394 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	181,214,853 - 181,223,505 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	181,164,961 - 181,173,618 (+)	NCBI
Celera	2	168,486,468 - 168,494,841 (+)	NCBI		Celera
RH 3.4 Map	2	1154.4	RGD
Cytogenetic Map	2	q34	NCBI

Pklr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	1,739,152 - 1,749,632 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	1,742,432 - 1,749,632 (-)	NCBI	ChiLan1.0	ChiLan1.0

PKLR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	42,263,899 - 42,272,770 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	42,263,761 - 42,272,755 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	41,754,768 - 41,762,716 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	42,132,983 - 42,141,903 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	42,133,018 - 42,141,000 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	41,912,888 - 41,920,846 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	41,966,693 - 41,974,641 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	42,250,696 - 42,258,642 (+)	NCBI		UU_Cfam_GSD_1.0

Pklr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	25,740,581 - 25,749,528 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	4,767,109 - 4,779,916 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	4,770,977 - 4,799,316 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKLR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	94,537,019 - 94,546,555 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	94,536,978 - 94,546,561 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	103,324,615 - 103,327,436 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKLR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	8,540,228 - 8,547,184 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	8,540,763 - 8,545,884 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	7,877,122 - 7,888,169 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pklr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	2,264,928 - 2,272,171 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624885	2,261,850 - 2,272,175 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003817047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055100725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000058341 ⟹ ENSPPAP00000035453

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	134,239,565 - 134,250,957 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000058342 ⟹ ENSPPAP00000035454

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	134,240,844 - 134,251,351 (-)	Ensembl

RefSeq Acc Id:

XM_003817047 ⟹ XP_003817095

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	94,540,674 - 94,554,495 (+)	NCBI
NHGRI_mPanPan1	1	94,272,005 - 94,285,754 (+)	NCBI
Mhudiblu_PPA_v0	1	130,634,111 - 130,645,637 (-)	NCBI
PanPan1.1	1	134,239,565 - 134,250,957 (-)	NCBI

Sequence:

show sequence

ACTTTAACCAGTCTGCAGAACTGATCCCCAGCCCAGCTGGGCCTCACGCCTCTGACAACCCAAC
AGTGTGGAGCAGACCCACAGAGAGGGAGACCCAGAGAGGTGTGCAGTGGCATGGAAGGGCCAGC
GGGGTATCTGCGGCGGGCCAGTGTGGCCCAACTGACCCAGGAGCTGGGCACTGCCTTCTTCCAG
CAGCAGCAGCTGCCAGCTGCTATGGCAGACACCTTCCTGGAACACCTCTGCCTACTGGACATTG
ACTCCGAGCCCGTGGCTGCTCGCAGTACCAGCATCATTGCCACCATCGGGCCAGCATCTCGCTC
CGTGGAGCGCCTCAAGGAGATGATCAAGGCCGGGATGAACATTGCGCGACTCAACTTCTCCCAC
GGCTCCCACGAGTACCATGCTGAGTCCATCGCCAACGTCCGGGAGGCGGTGGAGAGCTTTGCAG
GTTCCCCACTCAGCTACCGGCCCGTGGCCATCGCCCTGGACACCAAGGGACCGGAGATCCGCAC
TGGGATCCTGCAGGGGGGTCCAGAGTCGGACGTGGAGCTGGTGAAGGGCTCCCAGGTGCTGGTG
ACTGTGGACCCCGCGTTCCGGACGCGGGGGAACGCGAACACCGTGTGGGTGGACTACCCCAATA
TTGTCCGGGTCGTGCCGGTGGGGGGCCGCATCTACATTGACGACGGGCTCATCTCCCTAGTGGT
CCAGAAAATCGGCCCAGAGGGACTGGTGACCCAAGTGGAGAACGGCGGCGTCCTGGGCAGCCGG
AAGGGCGTGAACTTGCCAGGGGCCCAGGTGGACTTGCCCGGGCTGTCCGAGCAGGACGTCCGAG
ACCTGCGCTTCGGGGTGGAGCATGGGGTGGACATCGTCTTTGCCTCCTTTGTGCGGAAAGCCAG
CGACGTGGCTGCCGTCAGGGCTGCTCTGGGTCCGGAAGGACACGGCATCAAGATCATCAGCAAA
ATTGAGAACCACGAAGGTGTGAAGAGGTTTGATGAAATCCTGGAGGTGAGCGACGGCATCATGG
TGGCACGGGGGGACCTAGGCATCGAGATCCCAGCAGAGAAGGTTTTCCTGGCTCAGAAGATGAT
GATTGGGCGCTGCAACTTGGCGGGCAAGCCTGTTGTCTGTGCCACACAGATGCTGGAGAGCATG
ATTACCAAGCCCCGGCCAACGAGGGCAGAGACAAGCGATGTCGCCAATGCTGTGCTGGATGGGG
CTGACTGCATCATGCTGTCAGGGGAGACTGCCAAGGGCAACTTCCCTGTGGAAGCGGTGAAGAT
GCAGCATGCGATTGCCCGGGAGGCAGAGGCCGCAGTGTACCACCGGCAGCTGTTTGAGGAGCTA
CGTCGGGCAGCGCCACTAAGCCGTGATCCCACTGAGGTCACCGCCATTGGTGCTGTGGAGGCTG
CCTTCAAGTGCTGTGCTGCTGCCATCATTGTGCTGACCACAACTGGCCGCTCAGCCCAGCTTCT
GTCTCGGTACCGACCTCGGGCAGCAGTCATTGCTGTCACCCGCTCTGCCCAGGCTGCCCGCCAG
GTCCACTTATGCCGAGGAGTCTTCCCCTTGCTTTACCGTGAACCTCCAGAAGCCATCTGGGCAG
ATGATGTAGATCGCCGGGTGCAATTTGGCATTGAAAGTGGAAAGCTCCGTGGCTTCCTCCGTGT
TGGAGACCTGGTGATTGTGGTGACAGGCTGGCGACCTGGCTCCGGCTACACCAACATCATGCGG
GTGCTAAGCATATCCTGAGACGCCCCTCCCTCCTCTGGCCCAGCCTACCCTTGTACCCCATCCC
TTCCTCCCCAGTCTACGTTCTCCAGCCCACACCCCTCCAAAGCCCCACCTTTAAGTCCTCTCTT
CTCTATTCCTGACCCTCCCTACCTGAGGCCTATCTGAGACTATAACTGTCATCTAGCCCCTTCG
AGGTTGCCCCTTCCCCATCTCCATTTCACACAGGTCCTGAAAGTCTGTGTCCAATTATGCACTG
GCCACCCAACAGCACCAATTGTACATTCCCTGCATCCAATCTGCTCAGCAGGCCCTAAGATGCC
TTGAGTCTTTAATCCCAGTTTGGCTGGTTAATTCCATAACCCCAGGCATCCCATCCCTTGGGGT
GGGGGAGAGGGGAGACAGGGCAATCTTGTCCACAGTCTCCCATTCTCATATGTAGCCCTCATGA
TAATCTGGGCATCTCGTGCCAGGGCAGGCTACCCCTTCATGGTGACTAACAGTTACATGAAAGT
CCACGCTTTTGGGAAAACTGGGTGGGATGGATGCTGGGGAGAAGTGAGGGCTGGGCAGCTGATT
TTGTCACTGTCTTCACAACCTCCGTGCTGGGCTTGTAGACCACTGTCCTGGCTGCTCTCATGCC
TGCCTGATACCCTGCTTGGTCAAATCCCCGGCTGCTTCCTTCTGCACCCAGAAATTCCTTCCCA
CTCACTTTGTTCCCACACACAAACCAAGAGCCAAAAATGAGTGTGTCTATTTTATATTTAAACC
CAGCTGTTTGGAAGCAATTATAAAACTTCTCCCCCACACCAAGAACCCCAGAACTCCCCACCCA
GAAGGAAAGGAGACTTAGGGTCCTGGTCCCACAGTCTTTAATGCTGTAGAGTAGGAGAGGGGAC
AGGCAGAGTGAGGGTGGTAAAGGACTACTCTTGTCCCTGAGAAGGCAGAGGTGCTGGCTGGCCT
GCCCTTCCCCAGGCTTGGATACCTTGGGCCTTTCCCTTACTCCTGCACCAACAGCAAACTCAGA
AGGAAAAAACAAAACAAAACTCTAAAGGTAAACACGGTCCTTCTCCCTCTCTCATGTGGCTCCT
CCTGCCCCTACCTGGGAGAAGGTTCAAGTATTGCGCTGATGGGTTTGGGCAAGGACCACAGAGG
CTGGCATGGAGAGGCCCTGCCTCCTCCTACTCCTCCTGTCTCCTTACCTGAAAAGGAGGGGAGG
GATGGATAAAGGAATGGGTAAACAAAATTAATTGGTAACACATAAAGTTAGTAAATGAATAAAT
ACAATTAAATAAATGAA

hide sequence

RefSeq Acc Id:

XM_034936971 ⟹ XP_034792862

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	94,540,674 - 94,554,495 (+)	NCBI
NHGRI_mPanPan1	1	94,272,005 - 94,285,754 (+)	NCBI
Mhudiblu_PPA_v0	1	130,634,111 - 130,646,644 (-)	NCBI

RefSeq Acc Id:

XM_055100725 ⟹ XP_054956700

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	94,540,674 - 94,554,495 (+)	NCBI
NHGRI_mPanPan1	1	94,272,005 - 94,285,754 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003817095	(Get FASTA)	NCBI Sequence Viewer
	XP_034792862	(Get FASTA)	NCBI Sequence Viewer
	XP_054956700	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000035453
	ENSPPAP00000035453.1
	ENSPPAP00000035454.1

RefSeq Acc Id:	XP_003817095 ⟸ XM_003817047
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9C0K5 (UniProtKB/TrEMBL), A0A2R9CAT3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIG PASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKG PEIRTGILQGGPESDVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGL ISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASF VRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFL AQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPV EAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLR GFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS hide sequence

RefSeq Acc Id:	XP_034792862 ⟸ XM_034936971
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9CAT3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000035453 ⟸ ENSPPAT00000058341

RefSeq Acc Id:

ENSPPAP00000035454 ⟸ ENSPPAT00000058342

RefSeq Acc Id:	XP_054956700 ⟸ XM_055100725
- Peptide Label:	isoform X1

Protein Domains

Pyruvate kinase barrel Pyruvate kinase C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040530	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000058341.1	UniProtKB/TrEMBL
	ENSPPAT00000058342.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.33.10	UniProtKB/TrEMBL
	3.20.20.60	UniProtKB/TrEMBL
	3.40.1380.20	UniProtKB/TrEMBL
InterPro	Pyr_Knase	UniProtKB/TrEMBL
	Pyrv/PenolPyrv_Kinase-like_dom	UniProtKB/TrEMBL
	Pyrv_Kinase-like_dom_sf	UniProtKB/TrEMBL
	Pyrv_Knase-like_insert_dom_sf	UniProtKB/TrEMBL
	Pyrv_Knase_AS	UniProtKB/TrEMBL
	Pyrv_Knase_brl	UniProtKB/TrEMBL
	Pyrv_Knase_C	UniProtKB/TrEMBL
	Pyrv_Knase_C_sf	UniProtKB/TrEMBL
	Pyrv_Knase_insert_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100980055	UniProtKB/TrEMBL
NCBI Gene	PKLR	ENTREZGENE
PANTHER	PTHR11817	UniProtKB/TrEMBL
	PYRUVATE KINASE PKLR	UniProtKB/TrEMBL
Pfam	PF00224	UniProtKB/TrEMBL
	PK_C	UniProtKB/TrEMBL
PRINTS	PYRUVTKNASE	UniProtKB/TrEMBL
PROSITE	PYRUVATE_KINASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50800	UniProtKB/TrEMBL
	SSF51621	UniProtKB/TrEMBL
	SSF52935	UniProtKB/TrEMBL
UniProt	A0A2R9C0K5	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CAT3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-10-04	PKLR	pyruvate kinase L/R		pyruvate kinase, liver and RBC	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)