GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pklr | increases activity | EXP | | 6480464 | CTD | Glucose results in increased activity of PKLR protein | PMID:16644726 | Pklr | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of PKLR mRNA | PMID:16644726 PMID:16790840 PMID:2824512 PMID:31974165 PMID:8144600 | Pklr | multiple interactions | EXP | | 6480464 | CTD | 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Glucose results in increased expression of PKLR mRNA]; Fatty Acids affects the reaction [Glucose results in increased activity of PKLR protein]; Fatty Acids, Unsaturated inhibits the reaction [Glucose results in increased expression of PKLR mRNA]; Glucose promotes the reaction [H3F4 protein modified form binds to PKLR promoter]; Glucose promotes the reaction [H4C16 protein modified form binds to PKLR promoter]; Metformin inhibits the reaction [Glucose results in increased expression of PKLR mRNA]; pirinixic acid inhibits the reaction [Glucose results in increased activity of PKLR protein]; pirinixic acid inhibits the reaction [Glucose results in increased expression of PKLR mRNA] | PMID:16644726 PMID:31974165 | Pklr | increases expression | ISO | Pklr (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of PKLR mRNA | PMID:17786952 | Pklr | increases expression | ISO | PKLR (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of PKLR mRNA | PMID:27226639 | | ||||||||||||||||||||||
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